Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover

Siebuhr, Anne Sofie; Petersen, Kristian Kjær; Arendt-Nielsen, Lars; Egsgaard, Line Lindhardt; Eskehave, Thomas Navndrup; Christiansen, Claus; Simonsen, Ole; Hoeck, Hans Christian; Karsdal, Morten A.; Bay‐Jensen, Anne‐Christine

doi:10.1016/j.joca.2013.10.020

Cited by 94 publications

(86 citation statements)

References 32 publications

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“…It is possible that the high levels of C1M, C4M, and VICM in the blood are results of a systemic effect where subjects with a general increased remodeling of the ECM and IF have a higher likelihood of developing cancer. Furthermore, all markers have been found elevated in a number of diseases characterized by ECM remodeling and tissue inflammation and are, therefore, not specific to cancer (7)(8)(9)(36)(37)(38)(39). Finally, it needs to be elucidated if the results of this study can be applied to populations of other ages and ethnic backgrounds and if the biomarkers are more useful for certain types of solid cancer.…”

Section: Discussionmentioning

confidence: 99%

Remodeling of the Tumor Microenvironment Predicts Increased Risk of Cancer in Postmenopausal Women: The Prospective Epidemiologic Risk Factor (PERF I) Study

Bager

Willumsen

Kehlet

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: An altered tumor microenvironment is one of the earliest signs of cancer and an important driver of the disease. We have seen previously that biomarkers reflecting tumor microenvironment modifications, such as matrix metalloproteinase (MMP)-degraded type 1 collagen (C1M), MMP-degraded type IV collagen (C4M), and citrullinated and MMP-degraded vimentin (VICM), were higher in the serum of cancer patients than in healthy controls. However, it is not known if these biomarkers could predict an increased risk of cancer. The aim of this study was to investigate whether C1M, C4M, and VICM were elevated prior to diagnosis of solid cancers in a large prospective study.Methods: Between 1999 and 2001, 5,855 postmenopausal Danish women ages 48 to 89 years enrolled in the Prospective Epidemiologic Risk Factor study. Baseline demographics and

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Section: Discussionmentioning

confidence: 99%

Remodeling of the Tumor Microenvironment Predicts Increased Risk of Cancer in Postmenopausal Women: The Prospective Epidemiologic Risk Factor (PERF I) Study

Bager

Willumsen

Kehlet

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Unfortunately, at present, many of these technologies are investigated independently, and consequently, the statistical benefit of combining serologic, imaging, and genomic biomarkers and clinical data may be overlooked. A recently proposed solution for PHC in osteoarthritis (52,53) may be such a combination of modalities. To successfully build upon and validate such emerging combinations of biomarkers (54) will require increased collaboration across research groups and consortiums.…”

Section: Significance and Innovationsmentioning

confidence: 99%

Rheumatoid Arthritis: A Case for Personalized Health Care?

Karsdal

Bay‐Jensen

Henriksen

et al. 2014

Arthritis Care & Research

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“…Osteoarthrosis has no definitive cure [10][11][12], however, some treatments are recommended [3,9,13]. One of the non-invasive treatments for knee osteoarthritis is application of laser power.…”

Section: Introductionmentioning

confidence: 99%

“…One of the non-invasive treatments for knee osteoarthritis is application of laser power. Given the inflammatory nature of osteoarthritis, laser therapy is believed to be effective by reducing inflammation [9,11,14]. It also promotes fibroblasts, collagen synthesis, cell oxygen recovery, and bone remodeling [7,12].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Low Level Laser Therapy on Pain and Range of Motion of Patients With Knee Osteoarthritis

Koutenaei

Mosallanezhad

Naghikhani

et al. 2017

PTJ

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Purpose: Osteoarthritis is one the most common chronic diseases of the joints that mostly affects knee joint. Low power laser is one the minimally invasive treatments of osteoarthritis. However, the efficacy of this therapy is still controversial. This study aimed to evaluate the efficacy of low power laser therapy in reducing pain and increasing knee range of motion compared to placebo laser. Methods:This study was a double-blind clinical trial performed at a day clinic in Tehran, Iran, from March 2016 to February 2017. Treatment for both groups comprised 10 sessions, 5 times a week. In this study, low power laser with a wavelength of 810 nm and a power of 100 mW at 8 points was applied around the knee during two weeks of treatment. At the same time, laser was applied in the placebo group, but the power output was zero. Data analyses were performed by repeated measures ANOVA test using SPSS version 20. Results:The mean pain score at rest (P=0.691), as well as at activity (P=0.751) were not significantly different between the two groups. The range of motion of knee flexion (P=0.435), and the range of motion of knee extension (P=0.885) showed no significant difference between two groups. Both interventions over time lead to a significant change in pain at rest and at activity and also increase in the range of motion in knee flexion and extension (P<0.05). Conclusion:Both placebo treatment with routine physiotherapy and active laser therapy with routine physiotherapy decreased knee pain and increased knee range of motion in patients affected with osteoarthritis and there was no significant difference between two therapies.

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Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover

Cited by 94 publications

References 32 publications

Remodeling of the Tumor Microenvironment Predicts Increased Risk of Cancer in Postmenopausal Women: The Prospective Epidemiologic Risk Factor (PERF I) Study

Remodeling of the Tumor Microenvironment Predicts Increased Risk of Cancer in Postmenopausal Women: The Prospective Epidemiologic Risk Factor (PERF I) Study

Rheumatoid Arthritis: A Case for Personalized Health Care?

The Effect of Low Level Laser Therapy on Pain and Range of Motion of Patients With Knee Osteoarthritis

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