Identification and characterisation of a homolog of an activation gene for the recombination activating gene 1 (RAG 1) in amphioxus

Dong, Meiling; Fu, Yanli; Yu, Cuiling; Su, Jing; Huang, Shengfeng; Wu, Xiaokun; Wei, Jianwen; Yuan, Shaochun; Shen, Yang; Xu, Anlong

doi:10.1016/j.fsi.2004.11.001

Cited by 15 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cephalochordates have a functioning complement system operating via the alternative and lectin pathways, including with a distinctive expanded number of C1q-like genes (Huang et al, 2008;Messier-Solek et al, 2010). A RAG1 gene is present, and possibly a RAG2 gene as well (Dong et al, 2005).…”

Section: Immunological Novelty Among Animal Phyla: An Underappreciatementioning

confidence: 99%

Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life

Loker¹

2012

Front. Immun.

View full text Add to dashboard Cite

An emerging picture of the nature of immune systems across animal phyla reveals both conservatism of some features and the appearance among and within phyla of novel, lineage-specific defense solutions. The latter collectively represent a major and underappreciated form of animal diversity. Factors influencing this macroevolutionary (above the species level) pattern of novelty are considered and include adoption of different life styles, life histories, and body plans; a general advantage of being distinctive with respect to immune defenses; and the responses required to cope with parasites, many of which afflict hosts in a lineage-specific manner. This large-scale pattern of novelty implies that immunological phenomena can affect microevolutionary processes (at the population level within species) that can eventually lead to macroevolutionary events such as speciation, radiations, or extinctions. Immunologically based phenomena play a role in favoring intraspecific diversification, specialization and host specificity of parasites, and mechanisms are discussed whereby this could lead to parasite speciation. Host switching – the acquisition of new host species by parasites – is a major mechanism that drives parasite diversity and is frequently involved in disease emergence. It is also one that can be favored by reductions in immune competence of new hosts. Mechanisms involving immune phenomena favoring intraspecific diversification and speciation of host species are also discussed. A macroevolutionary perspective on immunology is invaluable in today’s world, including the need to study a broader range of species with distinctive immune systems. Many of these species are faced with extinction, another macroevolutionary process influenced by immune phenomena.

show abstract

Section: Immunological Novelty Among Animal Phyla: An Underappreciatementioning

confidence: 99%

Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life

Loker¹

2012

Front. Immun.

View full text Add to dashboard Cite

show abstract

“…In our EST database, no homologues of RAG1/2 genes were found. Nonetheless, one cDNA clone from amphioxus encoding 210 amino acids was found to be homologous to a mouse gene that facilitates RAG1 gene activation (59). In the human lymphoid progenitor cell line, two separate signals from stromal cells and cytokines can induce the expression of RAG1/2 genes (42).…”

Section: The Genes Encoding Igsf Membersmentioning

confidence: 99%

Genes “Waiting” for Recruitment by the Adaptive Immune System: The Insights from Amphioxus

Yu¹,

Dong²,

Wu³

et al. 2005

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

In seeking evidence of the existence of adaptive immune system (AIS) in ancient chordate, cDNA clones of six libraries from a protochordate, the Chinese amphioxus, were sequenced. Although the key molecules such as TCR, MHC, Ig, and RAG in AIS have not been identified from our database, we demonstrated in this study the extensive molecular evidence for the presence of genes homologous to many genes that are involved in AIS directly or indirectly, including some of which may represent the putative precursors of vertebrate AIS-related genes. The comparative analyses of these genes in different model organisms revealed the different fates of these genes during evolution. Their gene expression pattern suggested that the primitive digestive system is the pivotal place of the origin and evolution of the AIS. Our studies support the general statement that AIS appears after the jawless/jawed vertebrate split. However our study further reveals the fact that AIS is in its twilight in amphioxus and the evolution of the molecules in amphioxus are waiting for recruitment by the emergence of AIS.

show abstract

“…In the genome of Arabidopsis , there are 17 MtN3 / saliva family genes. In addition, an amphioxus gene ( AmphiRga ) similar to vertebrate Rga was reported recently (Dong et al, 2005). All proteins encoded by these genes contain two copies of the MtN3/saliva domain, except that one Arabidopsis protein (NP_201091) contains only one copy.…”

Section: Resultsmentioning

confidence: 91%

Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis

et al. 2005

View full text Add to dashboard Cite

Identification and characterisation of a homolog of an activation gene for the recombination activating gene 1 (RAG 1) in amphioxus

Cited by 15 publications

References 19 publications

Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life

Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life

Genes “Waiting” for Recruitment by the Adaptive Immune System: The Insights from Amphioxus

Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis

Contact Info

Product

Resources

About