Identification and assessment of the effects of chemicals on reproduction and development (reproductive toxicology)

Baeder, Christian; Wickramaratne, G A; Hummler, Hans; Merkle, J.; Schön, Henrik; Tuchmann-Duplessis, H

doi:10.1016/0278-6915(85)90075-4

Cited by 12 publications

(2 citation statements)

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“…In view of the necessarily comparatively low doses used during these long-term studies, they may not be sufficiently sensitive to detect most potentially teratogenic materials. The basis for these reproductive studies has been reviewed (Mattison, 1983;Baeder et al, 1985;; see Reproductive Toxicology).…”

Section: Reproductive Toxicitymentioning

confidence: 99%

Basic Elements of Toxicology

Ballantyne¹,

Marrs

Syversen

2009

General, Applied and Systems Toxicology

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Toxicology is a multidisciplinary science concerned with determining the potential of chemicals and certain physical agents, such as ionizing radiation, to produced adverse effects in living organisms. Adverse effects in the context of this definition are those that are detrimental to the normal functioning or survival of the organism. If such effects occur, it is necessary to know their nature, incidence, mechanism of production, factors influencing their development and reversibility. This overview chapter discusses the following major elements in the science of toxicology: historical aspects; definitions and scope; subdisciplines; routes of exposure; dosage‐response relationships; factors influencing toxicity; biohandling of xenobiotics; toxicity of mixtures; conduct and review of toxicology studies; hazard evaluation and risk assessment; professional and ethical issues.

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Section: Reproductive Toxicitymentioning

confidence: 99%

Basic Elements of Toxicology

Ballantyne¹,

Marrs

Syversen

2009

General, Applied and Systems Toxicology

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show abstract

“…A multitude of complicated lists, recommendations, and protocols have been formulated in the past for assessing reproductive toxicity. [54][55][56][57][58][59][60][61] Some of these schemes recommend measurement of 10 to 30 variables or as many as 13 different indices for assessment of a potential reproductive toxicant. For investigative endeavors in reproductive toxicology these proposals are certainly justifiable, but they seem much too cumbersome for easy generalization for screening large numbers of compounds.…”

Section: Variables For Assessment Of Toxicitymentioning

confidence: 99%