Identification and assessment of permeability enhancing vehicles for transdermal delivery of glucosamine hydrochloride

Han, In Hee; Choi, Sung-Up; Nam, Dae Young; Park, Young Mi; Kang, Myung Joo; Kang, Kyung‐Hwa; Kim, Yong Min; Bae, Gunho; Oh, Il Young; Park, Jae Hyung; Ye, Jin Soo; Choi, Yoon Bae; Kim, Duk Ki; Lee, Jaehwi; Choi, Young Wook

doi:10.1007/s12272-010-0215-4

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…Consistent with skin permeation study, skin retention of FNS increased significantly with lower MO content and with incorporation of additives (40,42). One of the reasons why the skin retention of drug was high when FNS-loaded LCN was coformulated with additives may be that these could act as cosolvents for FNS absorption within the skin (44).…”

Section: Discussionsupporting

confidence: 70%

“…Despite the fact that OA is a powerful penetration enhancer, it resulted in lower permeability. This is probably because much of the OA incorporated was retained within the lipophilic area of LCN, resulting in poor permeability enhancing effect (44). Consistent with skin permeation study, skin retention of FNS increased significantly with lower MO content and with incorporation of additives (40,42).…”

Section: Discussionsupporting

confidence: 61%

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Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

et al. 2012

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In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate the potential of this nanocarrier, FNS-loaded LCN was prepared by ultrasonication method and characterized for size, shape, in vitro release, and skin permeation-retention properties. The particle size ranged from 153.8 to 170.2 nm with a cubical shape and exhibited controlled release profile with less than 20% of the drug released in the first 24 h. The release profile was significantly altered with addition of different additives. Formulation with lower monoolein exhibited higher skin permeation with a flux rate of 0.061±0.005 μg cm(-2) h(-1) in 24 h. The permeation however, significantly increased with glycerol, propylene glycol, and polyethylene glycol 400, while it declined for the addition of oleic acid. A similar trend was observed with skin retention study. In conclusion, FNS-loaded LCN could be advocated as a viable alternative for oral administration of the drug.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionsupporting

confidence: 61%

Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

et al. 2012

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“…They can incorporate small-molecule drugs and large proteins, 11,12 and have the ability to enhance permeability. 13 Currently commercialized preparations of paeonol include a cyclodextrin injection, oral solution, and ointment. 14 Although paeonol preparations of gel and emulsion are being studied, combinations of paeonol with cubic gel and microemulsion gel have been less widely reported.…”

Section: Introductionmentioning

confidence: 99%

Transdermal delivery of paeonol using cubic gel and microemulsion gel

Luo¹,

Shen²,

Chen³

2011

IJN

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Background The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations. Methods Various microemulsion vehicles were prepared using isopropyl myristate as an oil phase, polyoxyethylated castor oil (Cremophor ® EL) as a surfactant, and polyethylene glycol 400 as a cosurfactant. In the optimum microemulsion gel formulation, carbomer 940 was selected as the gel matrix, and consisted of 1% paeonol, 4% isopropyl myristate, 28% Cremophor EL/polyethylene glycol 400 (1:1), and 67% water. The cubic gel was prepared containing 3% paeonol, 30% water, and 67% glyceryl monooleate. Results A skin permeability test using excised rat skins indicated that both the cubic gel and microemulsion gel formulations had higher permeability than did the paeonol solution. An in vivo pharmacokinetic study done in rats showed that the relative bioavailability of the cubic gel and microemulsion gel was enhanced by about 1.51-fold and 1.28-fold, respectively, compared with orally administered paeonol suspension. Conclusion Both the cubic gel and microemulsion gel formulations are promising delivery systems to enhance the skin permeability of paeonol, in particular the cubic gel.

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“…The permeability of drugs is poor because of high hydrophilicity, so the oleic acid coated on the nano-APETE enhances the permeation rate and these results were in agreement with previous reports. 34 Based on the results shown in Figure 9, the F1 sample has significant drug release over a period of 96 hours; after that the skin texture was collapsed. The initial cumulative drug release of F1 sample was much higher than the raw extract, but the raw extract does not release much.…”

Section: Ex Vivo Release Studymentioning

confidence: 99%

Photoprotective effects of apple peel nanoparticles

Bennet¹,

Kang²,

Gang³

et al. 2013

IJN

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Plants contain enriched bioactive molecules that can protect against skin diseases. Bioactive molecules become unstable and ineffective due to unfavorable conditions. In the present study, to improve the therapeutic efficacy of phytodrugs and enhance photoprotective capability, we used poly(D,L-lactide-co-glycolide) as a carrier of apple peel ethanolic extract (APETE) on permeation-enhanced nanoparticles (nano-APETE). The in vitro toxicity of nano-APETE-treated dermal fibroblast cells were studied in a bioimpedance system, and the results coincided with the viability assay. In addition, the continuous real-time evaluations of photodamage and photoprotective effect of nano-APETE on cells were studied. Among three different preparations of nano-APETE, the lowest concentration provided small, spherical, monodispersed, uniform particles which show high encapsulation, enhanced uptake, effective scavenging, and sustained intracellular delivery. Also, the nano-APETE is more flexible, allowing it to permeate through skin lipid membrane and release the drug in a sustained manner, thus confirming its ability as a sustained transdermal delivery. In summary, 50 μM nano-APETE shows strong synergistic photoprotective effects, thus demonstrating its higher activity on target sites for the treatment of skin damage, and would be of broad interest in the field of skin therapeutics.

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Identification and assessment of permeability enhancing vehicles for transdermal delivery of glucosamine hydrochloride

Cited by 12 publications

References 14 publications

Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

Transdermal delivery of paeonol using cubic gel and microemulsion gel

Photoprotective effects of apple peel nanoparticles

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