Identification and analysis of putative tRNA genes in baculovirus genomes

Oliveira, Hugo de Paula; Santos, Ethiane Rozo dos; Harrison, Robert L.; Ribeiro, Bergmann Morais; Ardisson-Araújo, Daniel Mendes Pereira

doi:10.1016/j.virusres.2022.198949

Cited by 3 publications

(2 citation statements)

References 71 publications

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“…tRNA genes have been predicted in the viruses of ssDNA (single-stranded DNA), ssRNA (single-stranded RNA) viruses, and many other viruses with dsDNA [66,67]. The presence of the tRNA genes in the genomes of viruses should compensate for differences in codon and/or amino acid usage between the virus and host, thus promoting efficient protein synthesis and/or thereby expanding the host range [67,68].…”

Section: Discussionmentioning

confidence: 99%

Virophages Found in Viromes from Lake Baikal

Potapov,

Belykh

2023

Biomolecules

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In this study, a previously little-studied group of viruses—virophages—was searched for and identified in the viromes of the ancient oligotrophic Lake Baikal. Virophages are small dsDNA viruses that parasitize giant viruses (e.g., Mimiviridae), which in turn affect unicellular eukaryotes. We analyzed eight viromes obtained from the deep-water areas of three basins of Lake Baikal and the shallow-water strait Maloye More in different seasons. The sequences of virophages were revealed in all viromes and were dominant after bacteriophages and algal viruses. Sixteen putative complete genomes of virophages were assembled, all of which contained four conserved genes encoding major capsid protein (MCP), minor capsid protein (mCP), maturation cysteine protease (PRO), and FtsK-HerA family DNA-packaging ATPase (ATPase). The MCP-based cluster analysis showed a sequence separation according to seasons, and a dependence on the geographical localization was not detected.

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Section: Discussionmentioning

confidence: 99%

Virophages Found in Viromes from Lake Baikal

Potapov,

Belykh

2023

Biomolecules

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“…Baculoviruses possess their own machinery for transcription and replication, and all reported members share at least 39 orthologous protein genes [ 12 , 13 , 14 ]. Interestingly, despite the extensive protein gene content in baculoviral genomes, the presence of non-coding RNA genes has also been observed, including those that encode microRNAs (miRNAs) [ 15 ] and even transfer RNAs (tRNAs) [ 16 ]. Based on the reported studies, there is evidence of informational overlap within baculoviral genomes, where both protein-coding and non-coding RNA molecules may be encoded in the same genomic locus [ 17 ].…”

Section: Baculovirus Biologymentioning

confidence: 99%

A Comprehensive Study of MicroRNA in Baculoviruses

Motta,

Cerrudo,

Belaich

2024

IJMS

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Baculoviruses are viral pathogens that infect different species of Lepidoptera, Diptera, and Hymenoptera, with a global distribution. Due to their biological characteristics and the biotechnological applications derived from these entities, the Baculoviridae family is an important subject of study and manipulation in the natural sciences. With the advent of RNA interference mechanisms, the presence of baculoviral genes that do not code for proteins but instead generate transcripts similar to microRNAs (miRNAs) has been described. These miRNAs are functionally associated with the regulation of gene expression, both in viral and host sequences. This article provides a comprehensive review of miRNA biogenesis, function, and characterization in general, with a specific focus on those identified in baculoviruses. Furthermore, it delves into the specific roles of baculoviral miRNAs in regulating viral and host genes and presents structural and thermodynamic stability studies that are useful for detecting shared characteristics with predictive utility. This review aims to expand our understanding of the baculoviral miRNAome, contributing to improvements in the production of baculovirus-based biopesticides, management of resistance phenomena in pests, enhancement of recombinant protein production systems, and development of diverse and improved BacMam vectors to meet biomedical demands.

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Evolutionary adaptation in the laboratory and the process of retrograde engineering augment autotrophic proliferation in Saccharomyces cerevisiae

Mirsalami,

Mirsalami

2024

Biochemical Engineering Journal

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Identification and analysis of putative tRNA genes in baculovirus genomes

Cited by 3 publications

References 71 publications

Virophages Found in Viromes from Lake Baikal

Virophages Found in Viromes from Lake Baikal

A Comprehensive Study of MicroRNA in Baculoviruses

Evolutionary adaptation in the laboratory and the process of retrograde engineering augment autotrophic proliferation in Saccharomyces cerevisiae

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