Identification and analysis of prognostic metabolic characteristics in colon adenocarcinoma

Yang, Yang; Yang, Xinyu; Ren, Shiqi; Cao, Yang; Wang, Ziheng; Cheng, Zhouyang

doi:10.1016/j.heliyon.2024.e27388

Cited by 2 publications

(1 citation statement)

References 31 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the BM is involved in the regulation of various cell functions, such as cell polarity, differentiation, and survival ( 10 , 11 ). The development of risk scores with specific attributes to evaluate the prognosis of CRC patients from various angles has been demonstrated as a feasible approach ( 24 ). However, to date, there is a lack of CRC prognostic models that incorporate the BM.…”

Section: Discussionmentioning

confidence: 99%

Identification of a basement membrane-related gene signature for predicting prognosis, immune infiltration, and drug sensitivity in colorectal cancer

Shengxiao,

Xinxin,

Yunxiang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

BackgroundColorectal cancer (CRC) is the most common malignancy affecting the gastrointestinal tract. Extensive research indicates that basement membranes (BMs) may play a crucial role in the initiation and progression of the disease.MethodsData on the RNA expression patterns and clinicopathological information of patients with CRC were sourced from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. A BM-linked risk signature for the prediction of overall survival (OS) was formulated using univariate Cox regression and combined machine learning techniques. Survival outcomes, functional pathways, the tumor microenvironment (TME), and responses to both immunotherapy and chemotherapy within varying risk classifications were also investigated. The expression trends of the model genes were evaluated by reverse transcription polymerase chain reaction (RT-PCR) and the Human Protein Atlas (HPA) database.ResultsA nine-gene risk signature containing UNC5C, TINAG, TIMP1, SPOCK3, MMP1, AGRN, UNC5A, ADAMTS4, and ITGA7 was constructed for the prediction of outcomes in patients with CRC. The expression profiles of these candidate genes were verified using RT-PCR and the HPA database and were found to be consistent with the findings on differential gene expression in the TCGA dataset. The validity of the signature was confirmed using the GEO cohort. The patients were stratified into different risk groups according to differences in clinicopathological characteristics, TME features, enrichment functions, and drug sensitivities. Lastly, the prognostic nomogram model based on the risk score was found to be effective in identifying high-risk patients and predicting OS.ConclusionA basement membrane-related risk signature was constructed and found to be effective for predicting the prognosis of patients with CRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of a basement membrane-related gene signature for predicting prognosis, immune infiltration, and drug sensitivity in colorectal cancer

Shengxiao,

Xinxin,

Yunxiang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Genetic Susceptibility of Thrombin Measurement Levels and the Risk of Colon Adenocarcinoma: A Mendelian Randomization Study

Liu,

Zhou

2024

Br J Hosp Med

View full text Add to dashboard Cite

Aims/Background: This investigation sought to establish a possible correlation between thrombin measurement levels and the risk of developing colon adenocarcinoma (COAD). Methods: Thrombin measurement levels were sourced from a study by Pietzner M (2020, PMID: 33328453) and integrated into the IEU database. Data on COAD were obtained from the FinnGen database (2021, C3_COLON_ADENO). Various analytical methods were used to assess the relationship, including inverse variance weighting (IVW), mendelian randomization-Egger (MR-Egger) regression, as well as weighted median and mode techniques. Sensitivity analyses were performed, including Cochran’s Q test, MR-Egger intercept test, mendelian randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), along with leave-one-out analysis, to ensure the robustness of the results. Results: The IVW analysis indicated a significant inverse association between elevated thrombin levels and the risk of COAD (odds ratio (OR) = 0.76, 95% CI = 0.66–0.88, p = 0.0003). These findings were supported by the weighted median analysis (OR = 0.78, 95% CI = 0.68–0.90, p = 0.0006) and the weighted mode analysis (OR = 0.78, 95% CI = 0.68–0.88, p = 0.0017). Conclusion: This research identified an inverse causal relationship between thrombin measurement levels and the incidence of COAD, suggesting that higher thrombin levels are associated with a reduced risk of developing COAD.

show abstract

Identification and analysis of prognostic metabolic characteristics in colon adenocarcinoma

Cited by 2 publications

References 31 publications

Identification of a basement membrane-related gene signature for predicting prognosis, immune infiltration, and drug sensitivity in colorectal cancer

Identification of a basement membrane-related gene signature for predicting prognosis, immune infiltration, and drug sensitivity in colorectal cancer

Genetic Susceptibility of Thrombin Measurement Levels and the Risk of Colon Adenocarcinoma: A Mendelian Randomization Study

Contact Info

Product

Resources

About