Identificación de microorganismos asociados con rinosinusitis crónica en pacientes adultos con inmunodeficiencia común variable

Angulo-Pérez, Gabriela; Vivar-Acevedo, Eulalio; Herrera-Sánchez, Diana Andrea

doi:10.29262/ram.v63i1.143

Cited by 1 publication

(4 citation statements)

References 11 publications

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“…NFKB1 common variable immunodeficiency with autoimmunity 12 (CVID12; MIM#616576) was identified postmortem in neonate 122, who died of Citrobacter koseri meningitis on DOL 9. There has been an association between CVID12 and neonatal infection, including C. koseri, and it is frequently managed with immunoglobulin replacement and antibiotic prophylaxis . Rapid WGS at neonatal ICU admission may have been followed by CVID12 diagnosis and treatment with intravenous immunoglobulin and promptly administered broad-spectrum antibiotics …”

Section: Resultsmentioning

confidence: 99%

“…There has been an association between CVID12 and neonatal infection, including C. koseri, and it is frequently managed with immunoglobulin replacement and antibiotic prophylaxis . Rapid WGS at neonatal ICU admission may have been followed by CVID12 diagnosis and treatment with intravenous immunoglobulin and promptly administered broad-spectrum antibiotics …”

Section: Resultsmentioning

confidence: 99%

“…managed with immunoglobulin replacement and antibiotic prophylaxis. [47][48][49] Rapid WGS at neonatal ICU admission may have been followed by CVID12 diagnosis and treatment with intravenous immunoglobulin and promptly administered broad-spectrum antibiotics. [47][48][49] Infant 183 died of cardiac arrest on DOL 123.…”

Section: Jama Network Open | Pediatricsmentioning

confidence: 99%

“…[47][48][49] Rapid WGS at neonatal ICU admission may have been followed by CVID12 diagnosis and treatment with intravenous immunoglobulin and promptly administered broad-spectrum antibiotics. [47][48][49] Infant 183 died of cardiac arrest on DOL 123. CACNA1C long QT syndrome 8 (LQT8; MIM#618447) was identified postmortem.…”

Section: Jama Network Open | Pediatricsmentioning

confidence: 99%

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Reclassification of the Etiology of Infant Mortality With Whole-Genome Sequencing

et al. 2023

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ImportanceUnderstanding the causes of infant mortality shapes public health, surveillance, and research investments. However, the association of single-locus (mendelian) genetic diseases with infant mortality is poorly understood.ObjectiveTo determine the association of genetic diseases with infant mortality.Design, Setting, and ParticipantsThis cohort study was conducted at a large pediatric hospital system in San Diego County (California) and included 546 infants (112 infant deaths [20.5%] and 434 infants [79.5%] with acute illness who survived; age, 0 to 1 year) who underwent diagnostic whole-genome sequencing (WGS) between January 2015 and December 2020. Data analysis was conducted between 2015 and 2022.ExposureInfants underwent WGS either premortem or postmortem with semiautomated phenotyping and diagnostic interpretation.Main Outcomes and MeasuresProportion of infant deaths associated with single-locus genetic diseases.ResultsAmong 112 infant deaths (54 girls [48.2%]; 8 [7.1%] African American or Black, 1 [0.9%] American Indian or Alaska Native, 8 [7.1%] Asian, 48 [42.9%] Hispanic, 1 [0.9%] Native Hawaiian or Pacific Islander, and 34 [30.4%] White infants) in San Diego County between 2015 and 2020, single-locus genetic diseases were the most common identifiable cause of infant mortality, with 47 genetic diseases identified in 46 infants (41%). Thirty-nine (83%) of these diseases had been previously reported to be associated with childhood mortality. Twenty-eight death certificates (62%) for 45 of the 46 infants did not mention a genetic etiology. Treatments that can improve outcomes were available for 14 (30%) of the genetic diseases. In 5 of 7 infants in whom genetic diseases were identified postmortem, death might have been avoided had rapid, diagnostic WGS been performed at time of symptom onset or regional intensive care unit admission.Conclusions and RelevanceIn this cohort study of 112 infant deaths, the association of genetic diseases with infant mortality was higher than previously recognized. Strategies to increase neonatal diagnosis of genetic diseases and immediately implement treatment may decrease infant mortality. Additional study is required to explore the generalizability of these findings and measure reduction in infant mortality.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%