Identificación de individuos con resistencia a la insulina mediante mediciones clínicas y marcadores bioquímicos de rutina. Construcción de un índice de riesgo individual

González, Lilliana; García, Saúl Suárez; Fernández, Vicente López; Cosmea, A. Álvarez; García, M.T. Arias; Menéndez, Francisco Álvarez

doi:10.1157/13106848

Cited by 1 publication

(1 citation statement)

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“…In this study, we evaluated lipid peroxidation, expressed as TBARS, nitric oxide metabolites (NO x ), and their ratio (TBARS/NO x ) in a group of MS subjects subdivided according to the presence or not of diabetes mellitus and also according to the degree of insulin resistance, expressed as triglycerides/HDL-cholesterol (TG/HDL-C) index; this index, in fact, may be considered an indicator of insulin resistance [33–35] its logarithm being inversely correlated with insulin sensitivity measures, such as the homeostasis model assessment and the quantitative insulin sensitivity check index [36]. …”

Section: Introductionmentioning

confidence: 99%

Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

Caimi

Presti

Montana

et al. 2014

Oxidative Medicine and Cellular Longevity

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Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed as NOx, and TBARS/NOx ratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS and NOx levels and a decrease in TBARS/NOx ratio in comparison with normal controls. Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase in NOx was present in subjects with a high TG/HDL-C index in comparison with those with a low index. In MS subjects we also found a negative correlation between TBARS/NOx ratio and TG/HDL-C index. Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.

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Section: Introductionmentioning

confidence: 99%