Identical twins with craniosynostosis of the sagittal suture

Keith, Joseph; Banik, Norbert; Falkner, Frank

doi:10.1007/bf02756282

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Finally, it is somewhat sad to note that, in the clinical literature at least, a constant uncritical claim is made for a genetic basis for premature cranial synostosis, with at least the implicit suggestion that such malfor mations are produced by genetic regulation acting at the level of the su tural tissues per se [Palacios and Schimke, 1969;Keith et al, 1968;Pereira et al, 1968], A much more reasonable, but as yet unproven, suggestion is that of Schonenberg [1967], that the defect may originate in the early embryonic prosencephalic head organizer. Should this con cept be true, the etiology of the dysostosis of the cranial base becomes developmentally understandable, with all of the secondary and consequent biomechanical changes leading to the terminal event of premature synos tosis [see G runeberg and W ickramatne, 1974, for an excellent example of such a process].…”

Section: Recent Work On Cranial Suturesmentioning

confidence: 99%

Functional Anatomy of Cranial Synostosis

Moss¹

1975

Pediatr Neurosurg

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An understanding of how sutural growth processes relate to the totality of cranial growth is necessary to cure the cause and not just the symptoms of cranial synostosis. There is no direct genetic determination for the origin, growth, size, shape or maintenance of bones. Rather, phenotypic expression of skeletal tissues is regulated via genetic information encoded in the cells of functional matrices. The primary morphogenetic event in neurocranial growth is the volumetric expansion of the neural mass, which causes the surrounding neurocranial capsule to expand. Calvarial bones arise at widely separated ossification centers and spread centrifugally towards each other. Premature synostosis of the human metopic suture was noted as a frequent characteristic of the cleft-palate skull. Primary morphological event associated with premature synostosis was a cranial base malformation. Cranial sutures permit passage of the neonatal head through the birth canal, permit slight relative variations between adjacent bones while keeping these same bones relatively approximated. All morphological attributes of cranial bones and of their sutures are extrinsically determined and regulated, including both the normal and premature synostosis of the cranial sutures. It seems reasonable to the author that premature synostosis originates in the early embryonic prosencephalic head organizer, which makes it developmentally understandable.

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Section: Recent Work On Cranial Suturesmentioning

confidence: 99%

Functional Anatomy of Cranial Synostosis

Moss¹

1975

Pediatr Neurosurg

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“…To date, all reported accounts of sagittal synostosis in twins have been in males [11,13]. Multiple synostoses, particularly those resulting in oxycephaly, are seemingly more common among relatives and twins [3,6,7].…”

Section: Discussionmentioning

confidence: 99%

Sagittal synostosis in twin girls

Tubbs

Oakes

2002

Child's Nervous System

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Non-syndromic single-suture craniosynostosis in triplets

et al. 2018

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The results of the genetic testing suggest the possibility of a rare variant contributing to the risk of midline craniosynostosis shared among the triplets, with potential modifiers at other genetic loci affecting the phenotype. We speculate mutations at loci within non-coding regions not captured by our genetic analysis may have been involved. Moreover, epigenetic factors as well as environmental factors including, but not limited to, in utero head constraint could have contributed to the observed phenotype.

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Identical twins with craniosynostosis of the sagittal suture

Cited by 3 publications

References 2 publications

Functional Anatomy of Cranial Synostosis

Functional Anatomy of Cranial Synostosis

Sagittal synostosis in twin girls

Non-syndromic single-suture craniosynostosis in triplets

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