Ideal lipid profile and genes for an extended life span

Kolovou, Genovefa; Kolovou, Vana; Vasiliadis, Ioannis; Wierzbicki, Anthony S.; Mikhailidis, Dimitri P.

doi:10.1097/hco.0b013e32834659d4

Cited by 12 publications

(12 citation statements)

References 111 publications

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“…Further investigations would be addressed to elucidate the molecular mechanisms involved in such regulation. During ageing usually an increase in total cholesterol levels occurs in both genders, while in advanced aging (octogenarians, nonagenarians), people show a lipid profile typical of low risk of atherosclerotic disease [46], with high HDL, low total cholesterol and low LDL and high HDL/total cholesterol ratio [47,48] compared with septuagenarians [48,49]. Epidemiological studies found that the plasma levels of HDL cholesterol decrease with increasing age, but in the elderly they are unchanged or slightly increased [50].…”

Section: Discussionmentioning

confidence: 99%

Plasma Clusterin and Lipid Profile: A Link with Aging and Cardiovascular Diseases in a Population with a Consistent Number of Centenarians

et al. 2015

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The role of Clusterin in attenuation of inflammation and reverse cholesterol transfer makes this molecule a potential candidate as a marker for cancer, cardiovascular disease, diabetes mellitus, and metabolic syndrome. In elderly subjects cardiovascular diseases represent the primary cause of death and different clinical studies have shown a positive correlation of these diseases with changes in the lipid pattern. This work aimed at evaluating the relationship between circulating clusterin and the biochemical parameters that characterize the lipid profile of a Sardinian population divided into five age groups including centenarians; the high frequency in Sardinia of these long-lived individuals gave us the opportunity to extend the range of the age groups to be analyzed to older ages and to better evaluate the changes in the lipid balance during ageing and its relationship with clusterin concentration in plasma. Our results showed that Clusterin concentration values of the youngest group were more similar with the centenarian’s group compared to the other age groups, and a positive correlation arises with LDL. Furthermore given the high prevalence of cardiovascular diseases in the population examined and the association of Clusterin with these pathologies we evaluated Clusterin concentration variation in two groups with or without cardiovascular diseases. In presence of cardiovascular disease, Clusterin is significantly related to the most atherogenic components of lipid profile (total cholesterol and LDL), especially in women, suggesting its potential role in modulating cardiovascular metabolic risk factors.

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Section: Discussionmentioning

confidence: 99%

Plasma Clusterin and Lipid Profile: A Link with Aging and Cardiovascular Diseases in a Population with a Consistent Number of Centenarians

et al. 2015

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“…Cholesterol concentrations in the blood tend to increase with age, and studies in elderly subjects still show that reducing cholesterol levels to achieve optimal concentrations is beneficial in reducing the development of atherosclerosis and progressive heart disease in this population [5]. Therefore, nutritional approaches to reduce cardiovascular disease risk in aging populations should focus on modifying both risk factors-plasma cholesterol and inflammation.…”

Section: Impact Of Soy Protein On Cardiometabolic Healthmentioning

confidence: 95%

Evidence Supports the Use of Soy Protein to Promote Cardiometabolic Health and Muscle Development

Paul

Mendelson

2015

Journal of the American College of Nutrition

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Consumption of adequate amounts of dietary protein can help individuals maintain a healthy body composition, especially when combined with resistance exercise and during weight loss. It is well established that dietary protein intake supports muscle development and helps reduce loss of lean body mass during weight loss. Numerous studies have demonstrated the efficacy of soy protein intake for promoting fat loss while preserving muscle mass and supporting lean body mass gains. In fact, soy protein and animal-based proteins both support weight loss and weight maintenance equally as part of an energy-restricted diet; however, soy protein offers additional cardiometabolic advantages. Key teaching points: Soy protein is a high-quality, plant-based protein that can be consumed throughout the life span. More human clinical studies have been conducted to assess the cholesterol-lowering effects of soy protein than any other cholesterol-lowering food ingredient. Ingestion of proteins with unique and complementary characteristics like soy, whey, and casein helps resistance-trained individuals achieve significant muscle growth. Recent research supports the efficacy of consuming a combination of soy, whey, and casein after resistance exercise to extend the time period that muscle building occurs.

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“…Statins inhibit HMG-CoA reductase, leading to reduced levels of low density lipoprotein (LDL) associated cholesterol and are widely used with efficacy in cardiovascular disease states (109, 110). Statins may also prevent cellular senescence, possibly through reducing levels of reactive oxygen species and/or stabilizing telomere structures (111).…”

Section: Other Drugs Linked To Agingmentioning

confidence: 99%

Drugs that modulate aging: the promising yet difficult path ahead

Kennedy

Pennypacker

2014

Translational Research

117

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Once a backwater in medical sciences, aging research has emerged and now threatens to take the forefront. This dramatic change of stature is driven from three major events. First and foremost, the world is rapidly getting old. Never before have we lived in a demographic environment like today and the trends will continue such that 20% percent of the global population of 9 billion will be over the age of 60 by 2050. Given current trends of sharply increasing chronic disease incidence, economic disaster from the impending silver tsunami may be ahead. A second major driver on the rise is the dramatic progress that aging research has made using invertebrate models such as worms, flies and yeast. Genetic approaches using these organisms have led to hundreds of aging genes and, perhaps surprisingly, strong evidence of evolutionary conservation among longevity pathways between disparate species, including mammals. Current studies suggest that this conservation may extend to humans. Finally, small molecules such as rapamycin and resveratrol have been identified that slow aging in model organisms, although only rapamycin to date impacts longevity in mice. The potential now exists to delay human aging, whether it is through known classes of small molecules or a plethora of emerging ones. But how can a drug that slows aging become approved and make it to market when aging is not defined as a disease. Here, we discuss the strategies to translate discoveries from aging research into drugs. Will aging research lead to novel therapies toward chronic disease, prevention of disease or be targeted directly at extending lifespan?

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Ideal lipid profile and genes for an extended life span

Abstract: The optimal cholesterol target, long-term tolerability and the specific effects of statins on other vascular-associated diseases of aging, for example arterial aneurysms, microvascular renal and cerebral disease (dementias), remain to be determined.

Cited by 12 publications

References 111 publications

Plasma Clusterin and Lipid Profile: A Link with Aging and Cardiovascular Diseases in a Population with a Consistent Number of Centenarians

Plasma Clusterin and Lipid Profile: A Link with Aging and Cardiovascular Diseases in a Population with a Consistent Number of Centenarians

Evidence Supports the Use of Soy Protein to Promote Cardiometabolic Health and Muscle Development

Drugs that modulate aging: the promising yet difficult path ahead

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