Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues
Markus Müller,
Konstantin Niemeyer,
Navin K. Ojha
et al.
Abstract:Directly probing the endogenous biological roles of target proteins with high spatial and temporal resolution, as non-invasively and reproducibly as possible, is a shared conceptual goal for research across many fields, as well as for targeted therapies. Here we describe the rational conceptual design and test-case practical implementation of a photopharmacological paradigm to empower high-performance photomodulation studiesin vivo. TRPC4/5 ion channels are involved in many spatiotemporally resolved circuits, … Show more
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