Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer

Rasmussen‐Torvik, Laura J.; Shay, Christina M.; Abramson, Judith; Friedrich, Christopher A.; Nettleton, Jennifer A.; Prizment, Anna E.; Folsom, Aaron R.

doi:10.1161/circulationaha.112.001183

Cited by 236 publications

(175 citation statements)

References 26 publications

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“…Numerous studies have established that higher numbers of ideal LS7 metrics or higher LS7 scores are strongly associated with favorable outcomes 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14. Our results are comparable to the findings of prior studies that have shown an inverse relationship between higher LS7 scores and the incidence of non‐CVD 15, 16, 17, 18, 19. In the ARIC study, Rasmussen‐Torvik et al demonstrated that participants with 6 or 7 ideal metrics had a 51% lower risk of cancer compared with those with 0 to 2 ideal metrics 15…”

Section: Discussionsupporting

confidence: 87%

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Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis

Ogunmoroti

Allen

Cushman

et al. 2016

JAHA

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BackgroundThe American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We examined the association between the LS7 metrics and noncardiovascular disease.Methods and ResultsWe studied 6506 men and women aged between 45 and 84 years, enrolled in the Multi‐Ethnic Study of Atherosclerosis. Median follow‐up time was 10.2 years. Each component of the LS7 metrics (smoking, body mass index, physical activity, diet, total cholesterol, blood pressure, and blood glucose) was assigned points, 0 indicates “poor” category; 1, “intermediate,” and 2, “ideal.” The LS7 score, ranged from 0 to 14, was created from the points and categorized as optimal (11–14), average (9–10), and inadequate (0–8). Hazard ratios and event rates per 1000 person‐years were calculated for outcomes based on self‐reported hospitalizations with the International Classification of Diseases, 9th Revision, diagnoses of cancer, chronic kidney disease, pneumonia, deep venous thromboembolism/pulmonary embolism, chronic obstructive pulmonary disease, dementia, and hip fracture. Analyses were adjusted for age, sex, race/ethnicity, income, and education. Overall, noncardiovascular disease event rates were lower with increasing LS7 scores. With the inadequate LS7 score as reference, an optimal score was associated with a decreased risk for noncardiovascular disease events. The hazard ratio for cancer was, 0.80 (0.64–0.98); chronic kidney disease, 0.38 (0.27–0.54); pneumonia, 0.57 (0.40–0.80); deep venous thromboembolism/pulmonary embolism, 0.52 (0.33–0.82), and chronic obstructive pulmonary disease, 0.51 (0.31–0.83).ConclusionsThe American Heart Association's LS7 score identified individuals who were vulnerable to multiple chronic nonvascular conditions. These results suggest that improving cardiovascular health will also reduce the burden of cancer and other chronic diseases.

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Section: Discussionsupporting

confidence: 87%

“…The inverse relationship between ideal CVH and CVD incidence is well documented 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14. However, research exploring the association between ideal CVH and non‐CVDs has just begun 15, 16, 17, 18, 19…”

Section: Introductionmentioning

confidence: 99%

Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis

Ogunmoroti

Allen

Cushman

et al. 2016

JAHA

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“…Attainment of these ideal health metrics has been associated with lower incidence of cardiovascular disease, including coronary heart disease, myocardial infarction, heart failure,10, 11, 12, 13, 14 stroke,15 and retinopathy,16 in addition to noncardiovascular conditions, such as cancer 11, 17. Greater attainment of ideal cardiovascular health through midlife to late life is associated with both a lower prevalence of cardiovascular disease in late life and better cardiac structure and function in late life among people free of prevalent cardiovascular disease 18.…”

Section: Introductionmentioning

confidence: 99%

Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients

Sengeløv

Cheng

Biering‐Sørensen

et al. 2018

JAHA

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BackgroundThe relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and severity in late life.Methods and ResultsThe following 6 ideal cardiovascular health metrics were assessed in ARIC (Atherosclerosis Risk in Communities) Study participants at 5 examination visits between 1987 and 2013 (visits 1–4 in 1987–1998 and visit 5 in 2011–2013): smoking, body mass index, total cholesterol, blood pressure, physical activity, and blood glucose. Percentage attained CVHS was calculated in 6034 participants as the sum of CVHS at each visit/the maximum possible score. Aortic stenosis was assessed by echocardiography at visit 5 on the basis of the peak aortic valve velocity. Aortic stenosis was categorized sclerosis, mild stenosis, and moderate‐to‐severe stenosis. Mean age was 76±5 years, 42% were men, and 22% were black. Mean percentage attained CVHS was 63±14%, and the prevalence of aortic stenosis stages were 15.9% for sclerosis, 4.3% for mild stenosis, and 0.7% for moderate‐to‐severe stenosis. Worse percentage attained CVHS was associated with higher prevalence of aortic sclerosis (P<0.001 for trend), mild stenosis (P<0.001), and moderate‐to‐severe stenosis (P=0.002), adjusting for age, sex, and race.ConclusionsGreater attainment of ideal cardiovascular health in midlife to late life is associated with a lower prevalence of aortic sclerosis and stenosis in late life in a large cohort of older adults.

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“…AHA health metrics can be used for the assessment of trends in health status for primary preventive care [27,28]. Some studies showed that the number of AHA health metrics is negatively associated with stroke [30], myocardial infarction [30], cancer incidence [31] and mortality rates from all causes and CVD [27,29].…”

Section: Discussionmentioning

confidence: 99%

Which Measures of Health Status Assessment are the Most Significant in Organized Cohorts with Low Current Cardiovascular Risk? The Screening Study of Penitentiary Staff in Saratov Region, Russia

Kiselev

et al. 2016

Eurasian J Med

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Objective: The aim of the present study was to compare different methods of health status assessment in organized cohort of penitentiary employees in Saratov Region, Russian Federation. Materials and Methods: 1,014 penitentiary employees (81.8% male) aged 33.4±6.8 years were included in the cohort study. All participants underwent an annual preventive health examination in the Center of Medical and Social Rehabilitation of Russian Federal Penitentiary Service in Saratov Region. The prevalence of common cardiovascular risk factors was assessed. Risk Score and the number of fulfilled health metrics proposed by American Heart Association (AHA) were calculated for each participant. Results: It is shown that penitentiary staff in Saratov Region is characterized by low current risk score (1.2±0.8%), but high prevalence of such risk factors as increased body weight and obesity (51%), tobacco use or passive smoking (81%), and unhealthy diet (55%). 98.4% of participants had the Score level of ≤5%, but only 4.5% of penitentiary staff met the ideal cardiovascular health (they met all seven AHA health metrics). One fifth of the participants met three or less AHA health metrics. A statistically significant correlation between the risk Score and the number of fulfilled AHA health metrics is revealed (Chi-square = 5.1, p=0.024). The probability of fulfilment of less than 5 AHA health metrics in subjects with medium risk score is shown to be almost twofold greater than in subjects with low risk Score. However, there are a lot of differences in the assessment of cardiovascular health by risk Score and AHA health metrics. (%1,2±0,8) düşük olmakla birlikte, artan vücut ağırlığı ve obezite (%51), tütün kullanımı ya da pasif sigara (%81) ve sağlıksız beslenme (%55) gibi risk faktörlerinin yüksek prevalans ile karakterize olduğu gösterilmiştir. Katılımcıların %98,4'inin skoru %≤5 seviyesindeydi, ama cezaevi personelinin sadece %4,5'i (hepsi yedi AHA sağlık ölçeği ile uyumlu) ideal kalp sağlığı kriterlerine uymaktaydı. Katılımcıların beşte biri, üç veya daha az AHA sağlık ölçütlerine uymaktaydı. Risk puanı ve uyulan AHA sağlık ölçeği sayısı arasında istatistiksel olarak anlamlı bir ilişki (Ki-kare=5,1, p=0,024) ortaya çıkarılmıştır. Orta risk puanı olan kişilerde 5'ten az AHA sağlık ölçeğinin yerine getirilmesi olasılığının, düşük risk puanlı kişilerden neredeyse iki kat daha fazla olduğu gösterilmiş-tir. Ancak, kalp ve damar sağlığı değerlendirilmesinde risk puanı ve AHA sağlık ölçekleri arasında bir çok farklılık bulunmaktadır. Sonuç: Saratov Bölgesi cezaevi personeli gibi organize kohortlarda düşük kardiyovasküler risklerin önleyici yönetiminde AHA sağlık ölçeğinin kullanımı risk faktörlerinin ayrı ayrı değerlendiril-mesi ve risk skorlarına göre daha çok tercih edilebilir. Anahtar Kelimeler: Risk faktörleri, kardiyovasküler risk, sağlık ölçekleri, ceza infaz hizmeti Conclusion

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Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer

Cited by 236 publications

References 26 publications

Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis

Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis

Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients

Which Measures of Health Status Assessment are the Most Significant in Organized Cohorts with Low Current Cardiovascular Risk? The Screening Study of Penitentiary Staff in Saratov Region, Russia

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