Ideal cardiovascular health and risk of acute myocardial infarction among Finnish men

Isiozor, Nzechukwu M.; Kunutsor, Setor K; Voutilainen, Ari; Kurl, Sudhir; Kauhanen, Jussi; Laukkanen, Jari A.

doi:10.1016/j.atherosclerosis.2019.08.024

Cited by 21 publications

(19 citation statements)

References 25 publications

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“…A trained research nurse was responsible for interviewing all the study participants, who also went through a health examination. Details of the assessment for the blood pressure (BP), BMI, nutritional status, smoking status, alcohol consumption, physical activity, prevalent medical conditions and socioeconomic status (SES) have previously been discussed 6 . The SES scale ranges from 0 through 25; 0 indicating the highest, and 25 the lowest SES.…”

Section: Data Collectionmentioning

confidence: 99%

“…The CVH metrics adopted in this study was in conformity with the CVH metrics developed by AHA, consisting of 7 health behavioural and biological factors including healthy diet score (HDS), physical activity, BMI, smoking status, BP, fasting blood glucose and plasma total cholesterol 3,6 (Supplementary Table 1). Thus, the ideal CVH metric consists of: 1) HDS of 4 -5, i.e.…”

Section: Cardiovascular Health Metricsmentioning

confidence: 99%

“…Although several studies have established strong associations between the CVH metrics and various cardiovascular outcomes [4][5][6] , there remains a dearth of literature available on the association between AHA's CVH metrics and the risk of SCD. To the best of our knowledge, no study has at yet evaluated the association between the CVH metrics and risk of SCD.…”

Section: Introductionmentioning

confidence: 99%

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Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland

Isiozor

Kunutsor

Voutilainen

et al. 2020

European Journal of Preventive Cardiology

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Background Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland. Methods and results We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0–2 (poor), 3–4 (intermediate) and 5–7 (ideal). Multivariate Cox regression models were used to estimate the hazards ratios (HRs) and 95% confidence intervals (CIs) of ideal CVH metrics for SCD and all-cause mortality. During a median follow-up period of 25.8 years, 280 SCDs and 1289 all-cause mortality events were recorded. The risks of SCD and all-cause mortality decreased continuously with increasing number of CVH metrics across the range 2–7 ( p value for non-linearity for all <0.05). In multivariable analyses, men with an ideal CVH score had an 85% reduced risk of SCD compared with men with a poor CVH score (HR 0.15; 95% CI 0.05–0.48; p = 0.001). For all-cause mortality, there was a 67% lower risk among men with an ideal CVH score compared with those with a poor CVH score (HR 0.33; 95% CI 0.23–0.49; p <0.001). Conclusions Ideal CVH metrics were strongly and linearly associated with decreased risks of SCD and all-cause mortality among middle-aged men in Finland.

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Section: Data Collectionmentioning

confidence: 99%

Section: Cardiovascular Health Metricsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland

Isiozor

Kunutsor

Voutilainen

et al. 2020

European Journal of Preventive Cardiology

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“…Cardiovascular diseases have long been causing deaths to the largest number of humans. Acute Myocardial Infarction (AMI), one of the world's most common major cardiovascular diseases is characterized by high mortality and disability [1,2]. Despite the significant progress made in the treatment of AMI in recent years, its mortality rate remains relatively high [3].…”

Section: Introductionmentioning

confidence: 99%

Systems pharmacology dissection of the anti-myocardial ischemia-reperfusion injury mechanism for Ganjiang Fuzi decoction

Xie

Gou

et al. 2022

Preprint

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Background: As the commonest form of ischemic heart diseases, the Myocardial Ischemia-Reperfusion injury (MI/RI) accounts for almost 50 percent of all deaths. The prevention and treatment of MI/RI while reducing the mortality of myocardial infarction has become a raging topic of research in the cardiovascular field. At present, there are no effective drugs for the treatment of MI/RI. Hence, it becomes imperative to identify or develop efficient lead compounds for treating MI/RI. It has been reported that the Ganjiang Fuzi Decoction (GFD) could be used for the effective treatment of MI/RI due to its promotion of vasodilation and vascular endothelial cell proliferation besides reducing the oxidative damage. Methods: The network pharmacological methods were used in this study, for analyzing the biological processes and the molecular mechanisms of the GFD for MI/RI treatment. In vitro and in vivo experiments were performed for verification of the results of the network pharmacological predictions. Results: Around 16 active components of GFD were discovered against MI/RI, where aconitine, 6-ginger, mesaconitine, and hypaconitine were the leading ones with regard to the degree value. Moreover, it was found that 88 MI/RI-related targets mainly involved six aspects, apoptosis, oxidative stress, inflammation, mitochondrial energy metabolism, and vasodilation. In vitro studies indicated the ability of the GFD to increase the survival rate, decrease the apoptosis rate, reduce oxidative damage, and increase the expression of HIF-1α, VEGF, and eNOS in hypoxia/reoxygenation(H/R) injured Rat Vascular Endothelial Cells (RVEC). The in vivo studies illustrated the capacity of the GFD to reduce the myocardial tissue damage and the infarction area, while increasing the expression of HIF-1α, VEGF, and eNOS in the MI/RI rats. Conclusions: The results of this study confirmed the anti-MI/RI role of the GFD through the activation of the HIF-1α signaling pathway, promotion of vascular proliferation and dilation, and the reduction in oxidative damage. The findings of this study would further provide experimental evidence for the application of the GFD in the treatment of MI/RI.

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“…Studies have shown that changing poor behaviors and metabolic factors can reduce dyslipidemia as effectively as clinical drug therapy [9] . However, although healthy behaviors and metabolic factors were negatively correlated with the disease risk [10,11] , but the proportions of healthy behaviors and metabolic factors that meet the ideal levels were extremely low [12] .…”

mentioning

confidence: 96%

The Association of Healthy Behaviors and Metabolic Factors With Dyslipidemia Among Miao Adults: The China Multi-Ethnic Cohort (CMEC) Study

Nie¹,

Wang²,

Zeng³

et al. 2020

Preprint

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Background: Behavioral and metabolic risk factors will increase the risk of dyslipidemia, the association of behaviors and metabolic factors with dyslipidemia among Miao adults are still unclear. Objective: To evaluate the association between behaviors, metabolic factors and dyslipidemia.Methods: Based on the CMEC study, a representative samples of 5,559 Miao participants aged 30 to 79 years old who were included in the baseline survey from 2018 to 2019 were analyzed. A binary logistic regression model was utilized to evaluate the odds ratios (OR) and 95% confidence intervals (CI) of the associations of healthy behaviors and metabolic factors with dyslipidemia.Results: In both sexes, only a small percentage of females with ideal levels of waist-to-hip ratio (WHR) (27.2%). However, participants were more likely to have ideal levels of fasting blood glucose (FBG). In addition, males with dyslipidemia had poor levels of body mass index (BMI) (60.3%), WHR (59.2%) and FBG (65.8%). While females with dyslipidemia had poor levels of FBG (60.0%). Notably, our study found that WHR, BMI, FBG, and blood pressure were major risk factors for almost all dyslipidemia components. Conclusions: The rate of dyslipidemia cannot be ignored, particularly high TG levels. In addition, healthy behaviors and metabolic factors, especially WHR, BMI, FBG levels, and blood pressure were significantly associated with dyslipidemia, which may have become a major challenge to public health problems in the ethnic minority areas of Guizhou.

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Ideal cardiovascular health and risk of acute myocardial infarction among Finnish men

Abstract: This is a self-archived version of an original article. This version may differ from the original in pagination and typographic details.

Cited by 21 publications

References 25 publications

Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland

Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland

Systems pharmacology dissection of the anti-myocardial ischemia-reperfusion injury mechanism for Ganjiang Fuzi decoction

The Association of Healthy Behaviors and Metabolic Factors With Dyslipidemia Among Miao Adults: The China Multi-Ethnic Cohort (CMEC) Study

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Ideal cardiovascular health and risk of acute myocardial infarction among Finnish men

Abstract: This is a self-archived version of an original article. This version may differ from the original in pagination and typographic details.

Cited by 21 publications

References 25 publications

Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland

Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland

Systems pharmacology dissection of the anti-myocardial ischemia-reperfusion injury mechanism for Ganjiang Fuzi decoction

The Association of Healthy Behaviors and Metabolic Factors With Dyslipidemia Among Miao Adults:&nbsp;The&nbsp;China&nbsp;Multi-Ethnic&nbsp;Cohort&nbsp;(CMEC)&nbsp;Study

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The Association of Healthy Behaviors and Metabolic Factors With Dyslipidemia Among Miao Adults: The China Multi-Ethnic Cohort (CMEC) Study