Abstract:Background Hepatocellular carcinoma (HCC) has become a prominent global health threat due to its occurrence, lethality and dismal survival rates. Increasing prevalence of obesity and diabetes-induced non-alcoholic fatty liver disease (NAFLD) and metabolic syndromes have been found culpable for the rise of HCC initiation, via disruption of liver microenvironment. Super enhancers, which are characterised by high density of transcription binding sites, high-level transcription regulation and response to external … Show more
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