IDDF2018-ABS-0240 Role of human microbiota in skin dermatitis and eczema: a systematic review

Lee, Learn‐Han; Letchumanan, Vengadesh; Khan, Tahir Mehmood; Long, Ming; Chan, Kok-Gan; Goh, Bey Hing; Mutalib, Nurul Syakima Ab

doi:10.1136/gutjnl-2018-iddfabstracts.38

Cited by 6 publications

(6 citation statements)

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“…A plethora of health conditions have been associated with microbiome across a wide range of populations identifying a distinctive spread of microbiome in a selected patient cohort compared to a healthy cohort pointing to its potential etiological role in the occurrence of a commonly identified disorder. It is not an understatement if this could potentially invent a breakthrough management approach in curbing a wide variety of health disorders and pandemics which include obesity and cardiometabolic diseases, infections, respiratory, allergic, gastrointestinal, neuropsychiatric disorders and even cancers [7][8][9][10][11][12][13][14]. The National Institutes of Health (NIH) Human Microbiome Project, launched in 2007, was one of the large-scale projects initiated to support and catalyst the growth of this emerging field of research.…”

Section: Introductionmentioning

confidence: 99%

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome

et al. 2020

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The study of human microbiota and health has emerged as one of the ubiquitous research pursuits in recent decades which certainly warrants the attention of both researchers and clinicians. Many health conditions have been linked to the gut microbiota which is the largest reservoir of microbes in the human body. Autism spectrum disorder (ASD) is one of the neurodevelopmental disorders which has been extensively explored in relation to gut microbiome. The utilization of microbial knowledge promises a more integrative perspective in understanding this disorder, albeit being an emerging field in research. More interestingly, oral and vaginal microbiomes, indicating possible maternal influence, have equally drawn the attention of researchers to study their potential roles in the etiopathology of ASD. Therefore, this review attempts to integrate the knowledge of microbiome and its significance in relation to ASD including the hypothetical aetiology of ASD and its commonly associated comorbidities. The microbiota-based interventions including diet, prebiotics, probiotics, antibiotics, and faecal microbial transplant (FMT) have also been explored in relation to ASD. Of these, diet and probiotics are seemingly promising breakthrough interventions in the context of ASD for lesser known side effects, feasibility and easier administration, although more studies are needed to ascertain the actual clinical efficacy of these interventions. The existing knowledge and research gaps call for a more expanded and resolute research efforts in establishing the relationship between autism and microbiomes.

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Section: Introductionmentioning

confidence: 99%

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome

et al. 2020

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“…Gut microbiome has been reported to be associated with various human diseases [ 106 , 107 , 108 , 109 , 110 , 111 ]. The pattern and magnitude of the bacterial gut disruption is an active ongoing research subject in preterm infants with adverse outcomes.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Role of Gut Bacteria in Health and Disease in Preterm Neonates

Lee

Tan

Ramadas

et al. 2020

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The mortality rate of very preterm infants with birth weight <1500 g is as high as 15%. The survivors till discharge have a high incidence of significant morbidity, which includes necrotising enterocolitis (NEC), early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS). More than 25% of preterm births are associated with microbial invasion of amniotic cavity. The preterm gut microbiome subsequently undergoes an early disruption before achieving bacterial maturation. It is postulated that bacterial gut colonisation at birth and postnatal intestinal dysbacteriosis precede the development of NEC and LONS in very preterm infants. In fact, bacterial colonization patterns in preterm infants greatly differ from term infants due to maternal chorioamnionitis, gestational age, delivery method, feeding type, antibiotic exposure and the environment factor in neonatal intensive care unit (NICU). In this regard, this review provides an overview on the gut bacteria in preterm neonates’ meconium and stool. More than 50% of preterm meconium contains bacteria and the proportion increases with lower gestational age. Researchers revealed that the gut bacterial diversity is reduced in preterm infants at risk for LONS and NEC. Nevertheless, the association between gut dysbacteriosis and NEC is inconclusive with regards to relative bacteria abundance and between-sample beta diversity indices. With most studies show a disruption of the Proteobacteria and Firmicutes preceding the NEC. Hence, this review sheds light on whether gut bacteria at birth either alone or in combination with postnatal gut dysbacteriosis are associated with mortality and the morbidity of LONS and NEC in very preterm infants.

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“…Over the past 20 years, extensive research on the human microbiome has indicated that human health, while heavily related to our own genome, is linked to a great degree on microbes which are living in and on our body [ 17 , 18 , 19 , 20 , 21 ]. The term microbiota refers to the collection of microorganisms present in a defined environment, including fungi, viruses and bacteria.…”

Section: The Role Of Colonic Microbiome and Biofilm In Colon Carcimentioning

confidence: 99%

Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?

Chew

Tan

Law

et al. 2020

Cancers

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Colorectal cancer (CRC) is a global public health issue which poses a substantial humanistic and economic burden on patients, healthcare systems and society. In recent years, intestinal dysbiosis has been suggested to be involved in the pathogenesis of CRC, with specific pathogens exhibiting oncogenic potentials such as Fusobacterium nucleatum, Escherichia coli and enterotoxigenic Bacteroides fragilis having been found to contribute to CRC development. More recently, it has been shown that initiation of CRC development by these microorganisms requires the formation of biofilms. Gut microbial biofilm forms in the inner colonic mucus layer and is composed of polymicrobial communities. Biofilm results in the redistribution of colonic epithelial cell E-cadherin, increases permeability of the gut and causes a loss of function of the intestinal barrier, all of which enhance intestinal dysbiosis. This literature review aims to compile the various strategies that target these pathogenic biofilms and could potentially play a role in the prevention of CRC. We explore the potential use of natural products, silver nanoparticles, upconverting nanoparticles, thiosalicylate complexes, anti-rheumatic agent (Auranofin), probiotics and quorum-sensing inhibitors as strategies to hinder colon carcinogenesis via targeting colon-associated biofilms.

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IDDF2018-ABS-0240 Role of human microbiota in skin dermatitis and eczema: a systematic review

Cited by 6 publications

References 0 publications

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome

Exploring the Role of Gut Bacteria in Health and Disease in Preterm Neonates

Targeting Gut Microbial Biofilms—A Key to Hinder Colon Carcinogenesis?

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