Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma

Takai, Noriyuki; Miyazaki, Tami; Fujisawa, Kayo; Nasu, Kaei; Miyakawa, Isao

doi:10.1016/s0304-3835(01)00433-5

Cited by 66 publications

(52 citation statements)

References 30 publications

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“…High level expression of ID-proteins is frequently observed in a variety of human tumors and particularly in the case of ID1 has been correlated with poor clinical outcome (Kleeff et al, 1998;Maruyama et al, 1999;Kebebew et al, 2000;Langlands et al, 2000;Lin et al, 2000;Hu et al, 2001;Polsky et al, 2001;Schindl et al, 2001Schindl et al, , 2003Takai et al, 2001;Schoppmann et al, 2003). To investigate whether ectopic expression of ID1 affects centrosome numbers, we established human foreskin keratinocyte (HFK) populations that stably expressed ID1, ID2, ID3, or ID4.…”

Section: Stable Ectopic Expression Of Id1 In Primary Cells Results Inmentioning

confidence: 99%

“…They exhibit similar binding affinities to the various bHLH proteins but exhibit different expression patterns and share strong sequence homologies only in the helix-loop-helix domain (Riechmann et al, 1994). Overexpression of ID-proteins, specifically overexpression of ID1, has been detected in various human tumors, and in some cases is correlated with poor clinical prognosis (Kleeff et al, 1998;Maruyama et al, 1999;Kebebew et al, 2000;Langlands et al, 2000;Lin et al, 2000;Hu et al, 2001;Polsky et al, 2001;Schindl et al, 2001Schindl et al, , 2003Takai et al, 2001;Schoppmann et al, 2003). However, it is not clear whether ID1 overexpression directly contributes to malignant progression or merely reflects enhanced proliferation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The helix–loop–helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers

et al. 2004

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Section: Stable Ectopic Expression Of Id1 In Primary Cells Results Inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The helix–loop–helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers

et al. 2004

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“…Overexpression of Id-1 in prostate cancer cells also promotes metastasis through increased angiogenesis and invasiveness (Coppe et al, 2004). Reduced expressions of Id-1 and Id-3 have been demonstrated to inhibit the metastatic ability of gastric cancer cells (Tsuchiya et al, 2005), and Id-1 expression has been shown to be associated with the presence of invasion in endometrial carcinoma (Takai et al, 2001) and tumour angiogenesis in human pancreatic cancer (Lee et al, 2004). In lines with these results, we found that primary ESCC at M1 stage had a significantly (P ¼ 0.012) higher nuclear expression of Id-1 than the M0 stage tumours.…”

Section: Discussionmentioning

confidence: 99%

Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma

Chan

et al. 2007

Br J Cancer

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Id protein family consists of four members namely Id-1 to Id-4. Different from other basic helix -loop -helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P ¼ 0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P ¼ 0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P ¼ 0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients.

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“…ID1 and S100A4, well-known as metastasis promoters in EEC, are overexpressed in high-grade EEC. 32,33 Furthermore, TGF-beta signaling is recognized as an important pathway that controls the S100A4-mediated cell invasion in endometrial cancers. 33 Nonetheless, neither miRBase nor TargetScan database predicts direct targeting of these mRNAs in the 3 0 UTR of miR-204.…”

Section: Cancer Cell Biologymentioning

confidence: 99%

Dysregulation of microRNA‐204 mediates migration and invasion of endometrial cancer by regulating FOXC1

Chung

Lau

Cheung

et al. 2011

Intl Journal of Cancer

155

128

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TXMicroRNAs (miRNAs) regulate mRNA stability and protein expression, and certain miRNAs have been demonstrated to act either as oncogenes or tumor suppressors. Differential miRNA expression signatures have been documented in many human cancers but the role of miRNAs in endometrioid endometrial cancer (EEC) remains poorly understood. This study identifies significantly dysregulated miRNAs of EEC cells, and characterizes their impact on the malignant phenotype. We studied the expression of 365 human miRNAs using Taqman low density arrays in EECs and normal endometriums. Candidate differentially expressed miRNAs were validated by quantitative real-time PCR. Expression of highly dysregulated miRNAs was examined in vitro through the effect of anti-/pre-miRNA transfection on the malignant phenotype. We identified 16 significantly dysregulated miRNAs in EEC and 7 of these are novel findings with respect to EEC. Antagonizing the function of miR-7, miR-194 and miR-449b, or overexpressing miR-204, repressed migration, invasion and extracellular matrix-adhesion in HEC1A endometrial cancer cells. FOXC1 was determined as a target gene of miR-204, and two binding sites in the 3 0 -untranslated region were validated by dual luciferase reporter assay. FOXC1 expression was inversely related to miR-204 expression in EEC. Functional analysis revealed the involvement of FOXC1 in migration and invasion of HEC1A cells. Our results present dysfunctional miRNAs in endometrial cancer and identify a crucial role for miR-204-FOXC1 interaction in endometrial cancer progression. This miRNA signature offers a potential biomarker for predicting EEC outcomes, and targeting of these cancer progression-and metastasis-related miRNAs offers a novel potential therapeutic strategy for the disease.Endometrial cancer is a common cause of gynecological cancer death. The most dominant subtype, endometrioid endometrial cancer (EEC), accounts for >80% of this cancer. Menopause and unopposed estrogenic stimulation are typical risk factors. Patients are generally treated with surgery, radiation, chemotherapy or hormone therapy. Patients with early stage disease have 5-year survival rates over 80%, however, about 15-20% develop metastasis. 1 These patients and those with advanced stage disease or recurrence have poor prognosis due to limitation of effective treatment. 2 Understanding the pathogenesis of this disease may provide insights for the development of novel therapeutic strategies.MicroRNAs (miRNAs) are small noncoding RNA molecules of 19-24 nucleotides that regulate gene expression posttranscriptionally through imperfect base pairing with the 3 0 -untranslated region (3 0 UTR) of target mRNAs, causing transcript degradation and translational inhibition. 3 Approximately 20-30% of all genes are targeted by miRNAs and a single miRNA may target as many as 200 genes. 4 In human cancers, >50% of the miRNA genes are located in chromosomal fragile sites, minimal regions containing loss of heterozygosity, minimal amplicons or common breakpoint regions. 5 DNA ...

show abstract

Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma

Cited by 66 publications

References 30 publications

The helix–loop–helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers

The helix–loop–helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers

Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma

Dysregulation of microRNA‐204 mediates migration and invasion of endometrial cancer by regulating FOXC1

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