ICTV virus taxonomy profile: Picobirnaviridae

Abstract

Picobirnaviridae is a family of viruses with bi-segmented (rarely unsegmented) dsRNA genomes comprising about 4.4 kbp in total, with small, non-enveloped spherical virions. The family includes one genus (Picobirnavirus) grouping three genetic clusters with high sequence variability, two defined by viruses infecting vertebrates and a third with viruses found in invertebrates. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of Picobirnaviridae, which is available at www.ictv.global/report/picobirnaviridae.

Virome diversity analysis reveals novel enteroviruses and a human picobirnavirus in stool samples from African green monkeys with diarrhea

“…Four strains 1J, 8J, 9J, 10J shared 70.32%-73.53% polyprotein amino acid identity, 57.58%-61.06% amino acid identity in P1 and 80.78%-83.56% amino acid identity in region 2C plus 3CD ( Picobirnaviruses are small, non-enveloped viruses with a genome of two unrelated linear dsRNA segments. Picobirnaviruses have been detected in the faeces of humans and a wide range of animals worldwide, but their pathogenicity remains unknown (Malik et al, 2014;Delmas et al, 2019). In this study, picobirnavirus sequences were detected from seven out of ten stool samples of green monkeys with diarrhea, suggesting a high picobirnavirus infection ratio in African green monkeys.…”

“…To further confirm the genetic relationships of enterovirus strains in our study with other enteroviruses, a phylogenetic tree ( Figure 2) On the basis of sequence diversity in RdRp, picobirnaviruses are classified into three genogroups (Delmas et al, 2019). To further confirm the relationships of SPBV-3 and other picobirnaviruses, a phylogenetic tree (Figure 3) based on RdRp amino acid sequences was constructed.…”

“…To further confirm the relationships of SPBV-3 and other picobirnaviruses, a phylogenetic tree (Figure 3) based on RdRp amino acid sequences was constructed. RdRp sequences from SPBV-3, GPBV6C2 and picobirnaviruses listed in the ICTV picobirnavirus report (Delmas et al, 2019) were included in the phylogenetic analysis. The maximum-likelihood phylogenetic tree was generated using the LG+G+I model.…”

Detection and Molecular Characterization of Picobirnaviruses (PBVs) in the Mongoose: Identification of a Novel PBV Using an Alternative Genetic Code

“…Picobirnaviruses (PBVs), members of the family Picobirnaviridae, are bi-segmented double-stranded RNA (dsRNA) viruses that have been reported in the feces/gut contents of a wide variety of host species, and rarely in the respiratory tract of cattle, humans, monkeys, and pigs [1][2][3][4][5][6]. Although the pathogenesis of PBVs have not yet been clearly elucidated, traditionally, PBVs have been considered as opportunistic enteric pathogens of mammals [1,5,6]. However, PBVs remain to be successfully 2 of 13 propagated in mammalian cell cultures, or gnotobiotic animals [1,5,6].…”

“…Although the pathogenesis of PBVs have not yet been clearly elucidated, traditionally, PBVs have been considered as opportunistic enteric pathogens of mammals [1,5,6]. However, PBVs remain to be successfully 2 of 13 propagated in mammalian cell cultures, or gnotobiotic animals [1,5,6]. On the other hand, PBVs have been detected in invertebrates, and recent studies have provided evidence that PBVs may in fact infect prokaryotic or fungal host cells [7][8][9][10][11].…”