Ictal bradycardia and asystole: An uncommon cause of syncope

Nový, Jan; Carruzzo, Alain; Pascale, Patrizio; Maeder-Ingvar, Malin; Genné, Daniel; Pruvot, Étienne; Despland, P. A.; Rossetti, Andrea O.

doi:10.1016/j.ijcard.2007.11.038

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…Seizure-induced bradycardia/ hypotension [611][612][613][614] Generally due to temporal lobe epilepsy. Postictal bradyarrhythmia is uncommon and likely originates from the temporal lobe or limbic system.…”

Section: Neurological Disordersmentioning

confidence: 99%

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Sheldon²,

et al. 2017

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Section: Neurological Disordersmentioning

confidence: 99%

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Sheldon²,

et al. 2017

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“…As for the usual occurrence of auditory aura we propose two hypotheses. According to the first one, the aura is not epileptic in origin but rather a presyncopal symptom resulting from cerebral hypoperfusion, since auditory auras during IA seizures are sometimes similar to auras presenting before syncope: Novy et al and Rossetti et al reported on IA patients with auditory auras presenting as “muffled sounds.” According to our second hypothesis, considering the benign epilepsy, and the normal neuroimaging and interictal EEG, sporadic cases of autosomal dominant lateral temporal lobe epilepsy (a condition with LGI1 mutation) could also explain the usual auditory aura. This is supported by the recent findings of Naasan et al, who recorded asystolic periods in LGI1‐antibody encephalitis.…”

Section: Discussionmentioning

confidence: 99%

Ictal asystole: A systematic review

et al. 2016

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Characteristics considered to be typical of IA (focal, left temporal seizures appearing on grounds of a long-lasting, intractable epilepsy) seem only partially legitimate. We suggest that in new-onset IA, female gender and a preexisting heart condition could serve as predispositions in an otherwise benign epilepsy. We speculate that in late-onset IA, male-predominant changes in neuronal networks in chronic, intractable epilepsy and an accompanying autonomic dysregulation serve as facilitating factors.

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“…Curiously, ictal bradyarrhythmia appears to be associated with a higher risk for SUDEP [6]. Several case reports have described asystole or bradycardia during epileptic seizures and linked these conditions to a higher risk for SUDEP [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats

Pansani

Colugnati

Schoorlemmer

et al. 2011

Epilepsy & Behavior

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It is thought that cardiovascular changes may contribute to sudden death in patients with epilepsy. To examine cardiovascular alterations that occur during epileptogenesis, we measured the heart rate of rats submitted to the electrical amygdala kindling model. Heart rate was recorded before, during, and after the induced seizures. Resting heart rate was increased in stages 1, 3, and 5 as compared with the unstimulated control condition. In the initial one third of the seizures, we observed bradycardia, which increased in intensity with increasing stage and was blocked by injecting methyl atropine. During stage 5 seizures, a rebound tachycardia was observed that also increased in intensity with increasing number of seizures. This study demonstrated the influence of seizure frequency on cardiac autonomic modulation, providing a basis for discussion of potential mechanisms that cause patients with epilepsy to die suddenly.

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Ictal bradycardia and asystole: An uncommon cause of syncope

Cited by 15 publications

References 17 publications

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Ictal asystole: A systematic review

Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats

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