Ictal and Interictal Phonophobia in Migraine—A Quantitative Controlled Study

Ashkenazi, Avi; Mushtaq, Aamir; Yang, Irene; Oshinsky, Michael L.

doi:10.1111/j.1468-2982.2008.01834.x

Cited by 62 publications

(75 citation statements)

References 16 publications

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“…The interictal sound aversion threshold for 1000, 4000, and 8000 Hz stimulation was significantly lower than that of controls and decreased further during ictal migraine (Ashkenazi et al, 2009). BAEPs are altered in migraine, especially the later PL5 and IPL P1 to P5 (Bussone et al, 1985;Firat et al, 2006;Kochar et al, 2002).…”

Section: Discussionmentioning

confidence: 90%

“…Auditory symptoms are prominent in migraine and are the focus of this study; they include fluctuating low-frequency hearing loss, sudden deafness, auditory hallucinations, tinnitus, and phonophobia. Significant phonophobia is often found in interictal migraine and worsened during ictal migraine compared to controls (Ashkenazi et al, 2009;Vingen et al, 1998). …”

Section: Introductionmentioning

confidence: 99%

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Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

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Migraine symptoms often include auditory discomfort. Nitroglycerin (NTG)-triggered central sensitization (CS) provides a rodent model of migraine, but auditory brainstem pathways have not yet been studied in this example. Our objective was to examine brainstem auditory evoked potentials (BAEPs) in rat CS as a measure of possible auditory abnormalities. We used four subdermal electrodes to record horizontal (h) and vertical (v) dipole channel BAEPs before and after injection of NTG or saline. We measured the peak latencies (PLs), interpeak latencies (IPLs), and amplitudes for detectable waveforms evoked by 8, 16, or 32 KHz auditory stimulation. At 8 KHz stimulation, vertical channel positive PLs of waves 4, 5, and 6 (vP4, vP5, and vP6), and related IPLs from earlier negative or positive peaks (vN1-vP4, vN1-vP5, vN1-vP6; vP3-vP4, vP3-vP6) increased significantly 2 hours after NTG injection compared to the saline group. However, BAEP peak amplitudes at all frequencies, PLs and IPLs from the horizontal channel at all frequencies, and the vertical channel stimulated at 16 and 32 KHz showed no significant/consistent change. For the first time in the rat CS model, we show that BAEP PLs and IPLs ranging from putative bilateral medial superior olivary nuclei (P4) to the more rostral structures such as the medial geniculate body (P6) were prolonged 2 hours after NTG administration. These BAEP alterations could reflect changes in neurotransmitters and/or hypoperfusion in the midbrain. The similarity of our results with previous human studies further validates the rodent CS model for future migraine research.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

View full text Add to dashboard Cite

show abstract

“…Cutaneous allodynia is believed to be related to abnormal modulation of descending pain signals (Bingel and Tracey, 2008, Moulton et al, 2008). Although these hypersensitivities are magnified during the ictal phase of migraine (Bigal et al, 2008, Kelman, 2004, Lipton et al, 2008, Russell et al, 1996, Wober-Bingol et al, 2004) these hypersensitivities can also persist during the interictal phase of migraine (Ashkenazi et al, 2009, Main et al, 1997, Schwedt et al, 2011, Schwedt et al, 2015), when patients are pain-free. Several studies have shown that migraine patients demonstrate hypersensitivities during the interictal phase including lower thresholds to heat-induced pain (Schwedt et al, 2015), higher sensitivity to touch and light using self-report questionnaires (Chen et al, 2015, Cucchiara et al, 2014, Lovati et al, 2008), and altered functional brain activation patterns to painful heat stimuli (Chen et al, 2015, Schwedt et al, 2014a, Schwedt et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Structural alterations of the brainstem in migraine

Chong

Plasencia

Schwedt

2017

NeuroImage: Clinical

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Atypical brainstem modulation of pain might contribute to changes in sensory processing typical of migraine. The study objective was to investigate whether migraine is associated with brainstem structural alterations that correlate with this altered pain processing.MRI T1-weighted images of 55 migraine patients and 58 healthy controls were used to: (1) create deformable mesh models of the brainstem that allow for shape analyses; (2) calculate volumes of the midbrain, pons, medulla and the superior cerebellar peduncles; (3) interrogate correlations between regional brainstem volumes, cutaneous heat pain thresholds, and allodynia symptoms.Migraineurs had smaller midbrain volumes (healthy controls = 61.28 mm3, SD = 5.89; migraineurs = 58.80 mm3, SD = 6.64; p = 0.038), and significant (p < 0.05) inward deformations in the ventral midbrain and pons, and outward deformations in the lateral medulla and dorsolateral pons relative to healthy controls. Migraineurs had a negative correlation between ASC-12 allodynia symptom severity with midbrain volume (r = − 0.32; p = 0.019) and a positive correlation between cutaneous heat pain thresholds with medulla (r = 0.337; p = 0.012) and cerebellar peduncle volumes (r = 0.435; p = 0.001).Migraineurs with greater symptoms of allodynia have smaller midbrain volumes and migraineurs with lower heat pain thresholds have smaller medulla and cerebellar peduncles. The brainstem likely plays a role in altered sensory processing in migraine and brainstem structure might reflect severity of allodynia and hypersensitivity to pain in migraine.

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“…[19] Quantitative testing shows that the interictal migraineur is more sensitive to sound compared to the non-migraine control and that the migraine patient is even more sensitive to sound during a migraine attack compared to the interictal period. [14, 19–20]…”

Section: Aberrant Unisensory Processing In Migrainementioning

confidence: 99%

Multisensory integration in migraine

Schwedt

2013

Current Opinion in Neurology

125

127

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Purpose of Review Migraine attacks consist of head pain and hypersensitivities to somatosensory, visual, auditory and olfactory stimuli. Investigating how the migraine brain simultaneously processes and responds to multiple incoming stimuli may yield insights into migraine pathophysiology and migraine symptoms. Recent Findings The presence and intensity of hypersensitivity to one stimulus type are positively associated with the presence and intensity of hypersensitivities to other stimuli and to headache intensity. Furthermore, exposure to visual, auditory and olfactory stimuli can trigger migraine attacks. These relationships suggest a role for multisensory integration in migraine. Summary Multisensory integration of somatosensory, visual, auditory and olfactory stimuli by the migraine brain may be an important concept for understanding migraine.

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Ictal and Interictal Phonophobia in Migraine—A Quantitative Controlled Study

Cited by 62 publications

References 16 publications

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Structural alterations of the brainstem in migraine

Multisensory integration in migraine

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