ICSI increases ongoing pregnancy rates in patients with poor response cycle: multivariate analysis of 2819 cycles

Maman, Ettie; Geva, Liat Lerner; Yerushalmi, Gil M.; Baum, Micha; Dor, Jehoshua; Hourvitz, Ariel

doi:10.1016/j.rbmo.2012.09.003

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…The selection COH protocol or the type of endometrial preparation used, were the decision of the treating physician and largely dependent on the fashion at the time. The protocols of ovarian stimulation follow up and oocyte retrieval have been described elsewhere [ 15 ]. In the vitrifies warmed cycles, patients underwent either natural cycle or assisted hormone replacement as described in a previous study conducted in our institution [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Influence of seasonal variation on in vitro fertilization success

et al. 2018

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ObjectiveTo evaluate the influence of seasonal variation on in vitro fertilization (IVF) outcome in a large cohort population.Methods & materialsA total of 5,765 IVF cycles conducted in Sheba medical center between 2013 and 2016 were retrospectively analyzed. The treatment cycles included 4214 ovarian stimulation and ovum pick up (OPU) cycles of which 3020 resulted in fresh embryo transfer and 1551 vitrified- warmed cycles of which1400 resulted in warmed embryo transfer. Cycles were assigned to seasons according to the date of OPU for fresh embryo transfer cycles or according to the date of embryo warming for vitrified warmed embryo transfer cycles.ResultsThere were no statistically significant differences between the calendar months or seasons concerning the number of oocytes retrieved or fertilization rate in the fresh cycles. Throughout the 4 years of the study, the monthly clinical pregnancy rate fluctuated between 18.2% and 27.9% per fresh embryo transfer (mean 23.3%) and between 17.7% and 29.4% per vitrified warmed embryo transfer (mean 23%). These fluctuations did not follow any specific seasonal pattern.ConclusionsOur study did not demonstrate any significant influence of the calendar months or seasons on the clinical pregnancy rates of fresh or vitrified warmed embryo transfers. It might be speculated that the complete pharmaceutical control of the ovarian and endometrial function, as well as the homogeneous treatments, procedures and laboratory equipment used during the study period have lowered the influence of seasonal effect on IVF treatment outcome.

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Section: Methodsmentioning

confidence: 99%

Influence of seasonal variation on in vitro fertilization success

et al. 2018

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“…In cases of poor oocyte quality, several studies support the efficacy of ICSI [ 9 , 10 ]. In addition, ICSI has been investigated as a possible fertilization method in patients with lower oocyte yield [ 10 , 11 , 12 ]; however, no study supported the routine use of ICSI in patients with low oocyte yield.…”

Section: Introductionmentioning

confidence: 99%

Embryonic development in human oocytes fertilized by split insemination

Kim

Youm

et al. 2015

Obstet Gynecol Sci

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ObjectiveTo compare the laboratory outcomes of intracytoplasmic sperm injection (ICSI) and conventional insemination using sibling oocytes in poor prognosis IVF cycles where ICSI is not indicated.MethodsCouples undergoing IVF with following conditions were enrolled: history of more than 3 years of unexplained infertility, history of ≥3 failed intrauterine insemination, leukocytospermia or wide variation in semen analysis, poor oocyte quality, or ≥50% of embryos had poor quality in previous IVF cycle(s). Couples with severe male factor requiring ICSI were excluded. Oocytes were randomly assigned to the conventional insemination (conventional group) or ICSI (ICSI group). Fertilization rate (FR), total fertilization failure, and embryonic development at day 3 and day 5 were assessed.ResultsA total of 309 mature oocytes from 37 IVF cycles (32 couples) were obtained: 161 were assigned to conventional group and 148 to ICSI group. FR was significantly higher in the ICSI group compared to the conventional group (90.5% vs. 72.7%, P<0.001). Total fertilization failure occurred in only one cycle in conventional group. On day 3, the percentage of cleavage stage embryos was higher in ICSI group however the difference was marginally significant (P=0.055). In 11 cycles in which day 5 culture was attempted, the percentage of blastocyst (per cleaved embryo) was significantly higher in the ICSI group than the conventional group (55.9% vs. 25.9%, P=0.029).ConclusionHigher FR and more blastocyst could be achieved by ICSI in specific circumstances. Fertilization method can be tailored accordingly to improve IVF outcomes.

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“…We also reviewed papers that studied female age along with other variables. Most demonstrated the trend expected (Shen et al, 2003;Kovacs et al, 2003;Pinto et al, 2009;Nelson & Lawlor, 2011;Huang et al, 2012;Maman et al, 2012;Ramezanzadeh et al, 2012;Berger et al, 2014;Hamdine et al, 2015;Coelho Neto et al, 2015;Nouri et al, 2015;Meijerink et al, 2016;Amsiejiene et al, 2017;Bocca et al, 2017;Hassan et al, 2017;McPherson et al, 2018;Peuranpää et al, 2020), but others found no or a varied relationship between female age and IVF/ICSI (Busnelli et al, 2014;Chen et al, 2015;Lefebvre et al, 2015;Niinimäki et al, 2015;Borges et al, 2017;Reljič et al, 2017).…”

Section: Female Agementioning

confidence: 91%

In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes

Ribeiro¹,

Sousa²

2022

JBRA

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The development of assisted reproductive technology has allowed offspring in infertile couples, and specifically, allowed infertile men to conceive through Intracytoplasmic Sperm Injection (ICSI). Despite the proven efficacy of In Vitro Fertilisation (IVF) and ICSI, many factors can influence its success. In this review we present an analysis on the effect of Female age, Ovarian Reserve, Male age and Male factor on the outcomes of IVF/ICSI, to determine if and which can be applied to the practical context. A literature search on PubMed, EMBASE and MEDLINE for relevant articles was elaborated until July 2021, leading to the selection of 234 articles based on their titles. After reading through the abstracts, those that evaluated IVF/ ICSI predicting factors were selected. Finally, only those approaching female age, ovarian reserve, male age and male factor were considered in this review. Higher female age and baseline ovarian markers alterations such as lower anti-Müllerian hormone and antral follicular count, and higher basal follicle-stimulating hormone, were associated with poorer outcomes. The predictive value of Male age and Male factor presented varied results across literature. The multifactorial nature of male fertility makes evaluation difficult. Although the first assessment of male infertility is based on sperm concentration, motility and morphology, semen parameters have shown low prognostic value, whilst sperm DNA alterations gain importance. Nevertheless, results remain controversial. While some factors have proven to predict IVF/ICSI success, other need to be further studied to be applied to practical context to allow the best prognosis possible.

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ICSI increases ongoing pregnancy rates in patients with poor response cycle: multivariate analysis of 2819 cycles

Cited by 16 publications

References 22 publications

Influence of seasonal variation on in vitro fertilization success

Influence of seasonal variation on in vitro fertilization success

Embryonic development in human oocytes fertilized by split insemination

In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes

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