ICPEMC publication no. 8 polygenic effects and genetic changes affecting quantitative traits

Ramel, Claes

doi:10.1016/0165-1110(83)90022-2

Cited by 18 publications

(4 citation statements)

References 28 publications

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“…body weight at 67 weeks) than genotype-related ones deserves attention. Variations of multifactorial quantitative traits like those we evaluated, whether spontaneous or experimental, are often moderate (Ramel, 1983;Vogel and Motulski, 1997). Thus, the pattern of the cryopreservation-related differences was compatible with the hypothesis of slight and probably heterogenous alterations of intrinsic developmental determinants.…”

Section: Size Of the Differencesmentioning

confidence: 90%

Embryo cryopreservation and development: facts, questions and responsibility

Dulioust

Busnel²,

Carlier³

et al. 1999

Human Reproduction

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Section: Size Of the Differencesmentioning

confidence: 90%

Embryo cryopreservation and development: facts, questions and responsibility

Dulioust

Busnel²,

Carlier³

et al. 1999

Human Reproduction

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“…There is at least one reason for such high genetic vulnerability in the brain in that it is the most polygenetically determined organ [65]. We know in fact that damage to polygenic groups is much more frequent than pinpoint mutations and that it causes, as shown in the drosophila, some slight changes in the phenotype which alter some types of function but which are compatible with life [ 66].…”

Section: Paternal Factorsmentioning

confidence: 99%

Behavioral Teratogenesis: An Extension to the Teratogenesis of Functions

Auroux

1997

Neonatology

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Major malformations correspond to pathology during the first 2 months of gestation. Thereafter, histological and biochemical abnormalities can result from different negative maternal incidents and, without obvious malformations, change the phenotype of the conceptus. These abnormalities lead to essentially functional disorders often compatible with life and to more or less serious handicaps. All systems, when they arrive at such a stage of development, can be theoretically involved. The central nervous system (CNS) offers a very clear example of such weaknesses because its maturation is particularly long and susceptible to changes even after birth. The steps of this maturation overlap and form a continuum reflected in the pathology. Mental retardation occurring in children born of mothers who were subjected to atomic radiation, or ingested methylmercury from industrial waste, or who suffered the effects of lead, alcohol or tobacco constitutes a clear clinical example. Animal experiments confirm these data, adding pathogenic explanations. These experiments also explore the possible consequences that some medical techniques such as modern reproductive technology, for example embryo freezing, can have on the development of the conceptus. Toxic substances or drugs can also be responsible for such abnormalities through a genetic attack on spermatogenesis. Behavioral teratogenesis also opens a larger persepective related to the optimal quality of the conceptus and the determining factors, from stress or dietary factors during apparently normal pregnancy to paternal age at the moment of conception. Finally, given that other systems than the CNS can be involved in histological or biochemical abnormalities, such as the reproductive system, we must ask what other types of functional pathology can be induced by interventions on gametes, the embryo and the fetus. Thus, behavioral teratogenesis leads to the teratogenesis of functions.

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“…The assay systems often used in mutation research focus on standard genetic endpoints, ie, point mutations with major and discrete effects and chromosomal ab.err.ations. However, when considering mutations affecting the polygenic systems of fitness characters, quantitative genetic analysis can contribute important information to the understanding of these mechanisms (see eg Ramel, 1983).…”

Section: Introduction ' 'mentioning

confidence: 99%

A genetic evaluation of male reproductive fitness at early and late age in Drosophila melanogaster treated with a mutagen

Björklund¹,

Engström²,

Liljedahl³

1993

Genet. Sel. Evol.

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The effect of ethyl methane sulfonate-induced mutations in different germ cell stages on male reproductive fitness at early and late age, compared to an untreated control, was investigated in a laboratory population of Drosophila melanogaster. Indication of active DNA repair processes after mutagen treatment was obtained in the pre-meiotic germ cell stages. Genetic parameters for the male fitness trait, ie "number of progeny" were estimated in a succession of different broods at early and late ages. Heritability estimates for progeny size were found to vary between 0.13 and 0.97 in the different brood stages and over the 2 treatment groups. The estimates of genotype-environment interaction, as well as genetic correlations, suggest that the genetic determination of progeny size is different at an early age between EMS-treated and untreated individuals, but not at late ages. reproductive fitness / Drosophila melanogaster / genetic parameter / ageing / mutagen Résumé-Évaluation génétique des capacités de reproduction de mâles de différents âges exposés à un agent mutagène chez Drosophila melanogaster. Les ef jets des mutations induites par l'éthyl méthanesulfonate (EMS) au cours des différentes phases de la gamétogenèse sur la capacité de reproduction de mâles, jeunes ou âgés, ont été étudiés sur une population de laboratoire de Drosophila melanogaster. Des processus actifs de réparation de l'ADN, après traitement par l'EMS, existent vraisemblablement au cours des phases préméiotiques. Les paramètres génétiques relatifs au nombre de descendants par mâle ont été estimés dans plusieurs séries de ponte correspondant à différents âges. Les estimations de l'héritabilité de ce caractère varient de 0,17 à 0,67 dans les différentes séries de ponte et dans les deux groupes de mâles traités et non traités. Les estimations des interactions génotype-milieu, ainsi que des corrélations génétiques suggèrent que le déterminisme génétique du nombre de descendants est différent chez les jeunes mâles * Correspondence and reprints exposés à l'EMS par rapport aux mâles non traités. En revanche, aucune différence n'est détectée chez les mâles plus âgés. capacité de reproduction / Drosophila melanogaster / paramètre génétique / vieillissement / mutagène

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ICPEMC publication no. 8 polygenic effects and genetic changes affecting quantitative traits

Cited by 18 publications

References 28 publications

Embryo cryopreservation and development: facts, questions and responsibility

Embryo cryopreservation and development: facts, questions and responsibility

Behavioral Teratogenesis: An Extension to the Teratogenesis of Functions

A genetic evaluation of male reproductive fitness at early and late age in Drosophila melanogaster treated with a mutagen

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