ICOS promotes group 2 innate lymphoid cell activation in lungs

Kamachi, Fumitaka; Isshiki, Takuma; Harada, Norihiro; Akiba, Hisaya; Miyake, Sachiko

doi:10.1016/j.bbrc.2015.06.005

Cited by 35 publications

(39 citation statements)

References 33 publications

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“…Further, ICOS promoted ILC2 survival signaling and initiated ILC2-induced inflammation and AHR in Alternaria- or IL-33-challenged mice. Additional studies performed by other groups have supported ICOS/ICOS-L interactions as an important pathway of mouse ILC2 proliferation, homeostasis, and activation [81, 82]. Thus, the direct contact between ICOS and ICOS-ligand regulates ILC2 function and represents a therapeutic target of ILC2 activation and lung inflammation.…”

Section: Sources Of Ilc2 Activationmentioning

confidence: 92%

“…Direct cellular interactions between ICOS and ICOS-ligand have very recently been shown to regulate ILC2 function [80•, 81, 82]. ICOS is part of the immunoglobulin superfamily and was thought to be expressed solely on activated or memory Tcells, whereas ICOS-L was thought to be expressed by B cells and antigen-presenting cells [83].…”

Section: Sources Of Ilc2 Activationmentioning

confidence: 99%

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Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Karta

Broide

Doherty

2016

Curr Allergy Asthma Rep

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Recent discoveries have led to the identification of a novel group of immune cells, the innate lymphoid cells (ILCs). The members of this group are divided into three subpopulations: ILC1s, ILC2s, and ILC3s. ILC2s produce Th2 cytokines, IL-4, IL-5, and IL-13, upon activation by epithelial cell-derived cytokines, lipid mediators (cysteinyl leukotrienes and prostaglandin D2), and TNF family member TL1A and promote structural and immune cell responses in the airways after antigen exposure. In addition, ILC2 function is also influenced by inducible T cell costimulator (ICOS)/ ICOS-ligand (ICOS-L) interactions via direct contact between immune cells. The most common airway antigens are allergens and viruses which are highly linked to the induction of airway diseases with underlying type 2 inflammation including asthma and allergic rhinitis. Based on recent findings linking ILC2s and airway Th2 responses, there is intensive investigation into the role of ILC2s in human disease with the hope of a better understanding of the pathophysiology and the discovery of novel potential therapeutic targets. This review summarizes the recent advances made in elucidating ILC2 involvement in human Th2 airway disease.

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Section: Sources Of Ilc2 Activationmentioning

confidence: 92%

Section: Sources Of Ilc2 Activationmentioning

confidence: 99%

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Karta

Broide

Doherty

2016

Curr Allergy Asthma Rep

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“…The mechanisms of regulation of ILC2s have been studied at different levels of extrinsic and intrinsic molecular pathways as well as the regulatory effects of other cells on ILC2s. One of the most described co‐stimulatory molecules that plays an important role in the homeostasis and regulation of function of ILC2s is ICOS . ILC2s express ICOS and we were the first to discover that ILC2s also express ICOS‐L .…”

Section: Regulation Of Ilc2smentioning

confidence: 93%

“…One of the most described co‐stimulatory molecules that plays an important role in the homeostasis and regulation of function of ILC2s is ICOS . ILC2s express ICOS and we were the first to discover that ILC2s also express ICOS‐L . We showed that the genetic ablation of ICOS increases the apoptosis rate and impairs the cytokine production by ILC2s .…”

Section: Regulation Of Ilc2smentioning

confidence: 96%

Type two innate lymphoid cells: the Janus cells in health and disease

Maazi

Akbari

2017

Immunological Reviews

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Summary Innate lymphoid cells are functionally diverse subsets of immune cells including the conventional natural killer cells, lymphoid tissue inducers, type 1, 2 and 3 with significant roles in immunity and pathogenesis of inflammatory diseases. Type 2 innate lymphoid cells (ILC2s) resemble type 2 helper (Th2) cells in cytokine production and contribute to anti-helminth immunity, maintaining mucosal tissue integrity and adipose tissue browning. ILC2s play important roles in the pathogenesis of allergic diseases and asthma. Studying the pathways of activation and regulation of ILC2s are currently a priority for giving a better understanding of pathogenesis of diseases with immunological roots. Recently, our laboratory and others have shown several pathways of regulation of ILC2s by costimulatory molecules such as ICOS, regulatory T cells and by compounds such as nicotine. In this review, we summarize the current understanding of the mechanisms of activation and regulation of ILC2s and the role of these cells in health and disease.

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“…Ectopic expression of TCF-1 in BM LSK also induces the expression of many other genes shared by ILC and T lineages, such as the TCR-associated signaling molecules LAT, LCK, ITK and ICOS [27,30,48-50]. These molecules mediate TCR-signaling, and have also been recently implicated in the activation of innate lymphoid cells [18-20,51,52]. Hence, early BM ILC development may share key gene regulatory circuits with early thymic T cell development, which might underlie the striking function and gene expression similarity between innate lymphoid cells and adaptive T cells.…”

Section: Introductionmentioning

confidence: 99%

The development of adult innate lymphoid cells

Yang

Bhandoola

2016

Current Opinion in Immunology

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Innate lymphoid cells (ILC) are a specialized family of effector lymphocytes that transcriptionally and functionally mirror effector subsets of T cells, but differ from T cells in that they lack clonally-distributed adaptive antigen receptors. Our understanding of this family of lymphocytes is still in its infancy. In this review, we summarize current understanding and discuss recent insights into the cellular and molecular events that occur during early ILC development in adult mice. We discuss how these events overlap and diverge with the early development of adaptive T cells, and how they may influence the molecular and functional properties of mature ILC.

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ICOS promotes group 2 innate lymphoid cell activation in lungs

Cited by 35 publications

References 33 publications

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Type two innate lymphoid cells: the Janus cells in health and disease

The development of adult innate lymphoid cells

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