ICON: Eosinophil Disorders

Valent, Peter; Klion, Amy D.; Rosenwasser, Lanny J.; Arock, Michel; Bochner, Bruce S.; Butterfield, Joseph H.; Gotlib, Jason; Haferlach, Torsten; Hellmann, Andrzej; Horny, Hans Peter; Leiferman, Kristin M.; Metzgeroth, Georgia; Matsumoto, Kenji; Reiter, Andreas; Roufosse, Florence; Rothenberg, Marc E.; Simon, Hans Uwe; Sotlar, Karl; Vandenberghe, Peter; Weller, Peter F.; Gleich, Gerald J.

doi:10.1097/wox.0b013e31827f4192

Cited by 31 publications

(74 citation statements)

References 84 publications

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“…Thus, eosinophilia can be triggered through these eosinophilopoietic cytokines by increased eosinophil production, eosinophil longevity, or by a combination of these. [1,2,5] In addition, an evolving number of chemotactic cytokines have been established as causing eosinophils to migrate from their site of production in the bone marrow into the blood and then into peripheral tissues. These chemokines include eotaxin-1, eotaxin-2, and RANTES (regulated on activation normal T cell expressed and secreted).…”

Section: Discussionmentioning

confidence: 99%

Incidence of Eosinophilia in Rural Population in North India: A Study at Tertiary Care Hospital

Bansal

Kaur

Suri

et al. 2017

APALM

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Background: Eosinophilia is abnormally high number of eosinophils in the blood. Normally, eosinophils constitute 1 to 6% of the peripheral blood leukocytes, at a count of 350 to 650 per cubic millimeter. Eosinophilia can be categorized as mild (less than 1500 eosinophils per cubic millimeter), moderate (1500 to 5000 per cubic millimeter), or severe (more than 5000 per cubic millimeter). Eosinophilia may be primary or secondary. The aim of the study was to determine the incidence of eosinophilia and evaluate the patients thoroughly for the cause of eosinophilia. Method:The study was conducted in the Pathology department in the medical college and hospital in rural are of Punjab. Complete blood count and peripheral blood film study was done in almost all the patients visiting the hospital. The patients with eosinophilia were segregated and were made to fill the detailed proforma. The information included family history, chief complaints, food habits, disease history and drug history. A thorough general examination and diagnostic work up followed. Result:In all 3442 (10.7%) patients visiting the hospital had eosinophilia; out of this 2136 (62%) patients had mild eosinophilia, 1297 (37.7%) had moderate and 9 (0.3%) had severe eosinophilia. 2451(71.2%) patients were males and 991 (28.8%) were females. Age group of patients varied from 3 yrs to 74 yrs. The chief complaints of our patients were related to fever, cough, rashes, breathlessness, wheezing etc. other major group of patients had symptoms of abdominal pain, diarrhea, pallor, pica and loss of appetite.Conclusion: Eosinophilia appears to be a common occurrence in the in the rural population around our hospital. The most common etiologies were due to parasitic, protozoal or fungal infestations and infections. Allergy related problem also constituted a significant health problem in the local population.

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Section: Discussionmentioning

confidence: 99%

Incidence of Eosinophilia in Rural Population in North India: A Study at Tertiary Care Hospital

Bansal

Kaur

Suri

et al. 2017

APALM

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“…by enhanced production of eosinopoietins) (1). If blood eosinophil levels exceed 1.5 × 10 6 /l, the condition is referred to as hypereosinophilia (HE) (15–17). In the absence of any of the common triggers of eosinophilia (allergens, parasites, drugs), the term hypereosinophilic syndrome (HES) is appropriate if HE is documented over a period of at least 4 weeks and is accompanied by eosinophil-mediated organ damage (16).…”

Section: Introductionmentioning

confidence: 99%

“…A number of different HES classifications have been proposed, attempting to identify subgroups of patients who may respond similarly to particular therapies (1, 15–17). It is useful to distinguish between patients with an underlying primary or clonal process and those with secondary eosinophilia.…”

Section: Introductionmentioning

confidence: 99%

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Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

Radonjic-Hoesli

Valent

Klion

et al. 2015

Annu. Rev. Pharmacol. Toxicol.

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Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a life-long basis to keep eosinophil counts under control. In the last 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents, as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.

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“…The ICON on Eosinophil Disorders was published in 2012 in World Allergy Organization Journal [3]. An update of World Health Organization on diagnosis, risk stratification and management of eosinophilic disorders was published in 2014, including a new classification of hypereosinophilic syndromes [4].…”

Section: Introductionmentioning

confidence: 99%

Eosinophilia and Hypereosinophilic Disorders – Update on Etiopathogeny, Classification and Clinical Approach

Leru

2015

Romanian Journal of Internal Medicine

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Eosinophils are innate immune leukocytes recruited in large numbers to sites of allergic inflammation and parasitic infections. Recent studies show additional pleiotropic effects of recruited eosinophils impacting immunomodulation, tissue homeostasis and repair. Pathologic conditions accompanied by blood eosinophilia are quite frequent in medical practice and may raise serious differential diagnosis problems in severe cases, that require a multidisciplinary approach. Hypereosinophilia may be reactive to other diseases or primary, representing hypereosinophilic syndromes, that are diagnosed based on clinical and laboratory criteria, according to actual international guidelines. The etiopathogenic diagnosis is difficult and delayed in many cases and clinical evolution may be severe, with multiorgan involvement and poor prognosis. Some cases remain idiopathic, despite exhaustive investigation.This paper aims to review the most recent data in the literature referring to the role of eosinophils in human pathology, diagnostic criteria and treatment strategies of hypereosinophilic syndromes, actual classification and to draw some useful recommendations in clinical practice.

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ICON: Eosinophil Disorders

Cited by 31 publications

References 84 publications

Incidence of Eosinophilia in Rural Population in North India: A Study at Tertiary Care Hospital

Incidence of Eosinophilia in Rural Population in North India: A Study at Tertiary Care Hospital

Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

Eosinophilia and Hypereosinophilic Disorders – Update on Etiopathogeny, Classification and Clinical Approach

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