Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation

Ding, Zhe; Gómez, Teresa; Werkheiser, Jennifer L.; Cowan, Alan; Rawls, Scott M.

doi:10.1016/j.ejphar.2007.09.030

Cited by 40 publications

(39 citation statements)

References 78 publications

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“…33,34) Moreover, Ding et al showed that a potent TRPM8 agonist, icillin, causes hyperthermia in rats. 35) These results suggest that activation of TRPM8 induces thermogenesis. One of the autonomic thermoregulatory responses to cold, thermogenesis, might be enhanced in response to a cold-activated TRPM8 channel.…”

Section: Discussionmentioning

confidence: 57%

Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice

Masamoto

Kawabata

Fushiki

2009

Bioscience, Biotechnology, and Biochemistry

104

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Section: Discussionmentioning

confidence: 57%

Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice

Masamoto

Kawabata

Fushiki

2009

Bioscience, Biotechnology, and Biochemistry

104

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“…The interactions involving at least two different proteins (protein-protein interaction), and also posttranslational modifications, are thought to occur in specific intracellular compartments, which would explain why signals transmitted by NO present a spatial resolution (201,248). For instance, through protein-protein interactions it has been demonstrated that nNOS is recruited to the site of the NMDA receptor activation (218), and NMDA receptors are known to participate in mechanisms of euthermic control of T b (83). Not only may the regulation of NOS activity have important implications but also the different locations where NO is produced in the body.…”

Section: Elementary Aspects Of No Biologymentioning

confidence: 97%

Gaseous Mediators in Temperature Regulation

Branco

Soriano

Steiner

2014

Comprehensive Physiology

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Deep body temperature (Tb) is kept relatively constant despite a wide range of ambient temperature variation. Nevertheless, in particular situations it is beneficial to decrease or to increase Tb in a regulated manner. Under hypoxia for instance a regulated drop in Tb (anapyrexia) is key to reduce oxygen demand of tissues when oxygen availability is diminished, leading to an increased survival rate in a number of species when experiencing low levels of inspired oxygen. On the other hand, a regulated rise in Tb (fever) assists the healing process. These regulated changes in Tb are mediated by the brain, where afferent signals converge and the most important regions for the control of Tb are found. The brain (particularly some hypothalamic structures located in the preoptic area) modulates efferent activities that cause changes in heat production (modulating brown adipose tissue activity and perfusion, for instance) and heat loss (modulating tail skin vasculature blood flow, for instance). This review highlights key advances about the role of the gaseous neuromodulators nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) in thermoregulation, acting both on the brain and the periphery.

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“…[20][21][22][23] Mice and rats experience a transient drop in core body temperature following administration of TRPM8 antagonists. 20,22 This is apparently due to thermoregulatory systems of the brain misinterpreting the body's core temperature feedback system; consequently, thermogenesis factors such as vasoconstriction, oxygen consumption, brown adipose tissue thermogenesis, and cold-avoidance behavior are suppressed, resulting in a lower core temperature.…”

Section: Trp Channels Beyond Sensory Physiologymentioning

confidence: 99%

Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors

et al. 2015

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Transient receptor potential (TRP) ion channels are eukaryotic polymodal sensors that function as molecular cellular signal integrators. TRP family members sense and are modulated by a wide array of inputs, including temperature, pressure, pH, voltage, chemicals, lipids, and other proteins. These inputs induce signal transduction events mediated by nonselective cation passage through TRP channels. In this review, we focus on the thermosensitive TRP channels and highlight the emerging view that these channels play a variety of significant roles in physiology and pathophysiology in addition to sensory biology. We attempt to use this viewpoint as a framework to understand the complexity and controversy of TRP channel modulation and ultimately suggest that the complex functional behavior arises inherently because this class of protein is exquisitely sensitive to many diverse and distinct signal inputs. To illustrate this idea, we primarily focus on TRP channel thermosensing. We also offer a structural, biochemical, biophysical, and computational perspective that may help to bring more coherence and consensus in understanding the function of this important class of proteins.

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Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation

Cited by 40 publications

References 78 publications

Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice

Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice

Gaseous Mediators in Temperature Regulation

Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors

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