ICGC-ARGO precision medicine: an update on targeted therapy based on longitudinal analysis of tumour heterogeneity and evolution in colorectal cancer

Kotani, Daisuke; Nakamura, Yoshiaki; Fujisawa, Takao; Bando, Hideaki; Sakamoto, Naoya; Johns, Amber; Park, Keunchil; Casolino, Raffaella; Yoshino, Takayuki; Biankin, Andrew V.

doi:10.1016/s1470-2045(22)00650-7

Cited by 2 publications

(2 citation statements)

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“…If treatment decisions are based on a single biopsy sample that does not represent the entire tumor’s genetic landscape, there is a risk of underestimating the presence of resistant subclones. As a result, targeted therapies may be less effective than anticipated, and patients could experience disease progression due to the survival and growth of undetected resistant subpopulations. , …”

Section: Challenges and Considerations In Precision Medicine Implemen...mentioning

confidence: 99%

“…As a result, targeted therapies may be less effective than anticipated, and patients could experience disease progression due to the survival and growth of undetected resistant subpopulations. 157,158 Clonal evolution further complicates the treatment of colorectal cancer. Over time, the genetic makeup of the tumor can change, with certain subclones acquiring new mutations that provide a growth advantage.…”

Section: Tumor Heterogeneity and Clonal Evolutionmentioning

confidence: 99%

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Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Section: Challenges and Considerations In Precision Medicine Implemen...mentioning

confidence: 99%

Section: Tumor Heterogeneity and Clonal Evolutionmentioning

confidence: 99%

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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No association between cholecystectomy and risk of colorectal cancer: a meta-analysis of cohort studies

Liu

Yan

et al. 2023

Int J Colorectal Dis

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ICGC-ARGO precision medicine: an update on targeted therapy based on longitudinal analysis of tumour heterogeneity and evolution in colorectal cancer

Cited by 2 publications

References 0 publications

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

No association between cholecystectomy and risk of colorectal cancer: a meta-analysis of cohort studies

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