ICG@ZIF-8/PDA/Ag composites as chemo-photothermal antibacterial agents for efficient sterilization and enhanced wound disinfection

Abstract

Bacterial infection has increasingly affected people’s life, therefore it is significant to explore novel antibacterial agents and strategies for efficient disinfection. Herein, we designed ZIF-8 based composites ICG@ZIF-8/PDA/Ag, which encapsulate...

Dimensionality reduction boosts the peroxidase-like activity of bimetallic MOFs for enhanced multidrug-resistant bacteria eradication

“…As shown in Fig. 3e and f, almost all bacterial cells were stained by PI in the Co–Fe ND/H 2 O 2 treated groups in the LIVE/DEAD assay, 37,38 which was consistent with that determined by the MTT staining method. In addition, the antibacterial mechanism of Co–Fe NDs was further explored by measuring the intra-bacterial ROS level by DCFH-DA.…”

“…Skin is the first line of defense of the human body, serving as the physical barrier against external invasion. 37,38 Thus, based on the excellent antibacterial properties of Co-Fe NDs, the therapeutic effect of Co-Fe NDs on bacteria infected wounds was studied. Using female Balb/c mice infected with MRSA as the model, a round-like wound with a diameter of about 1 cm was created on the back of each mouse, and the wound was infected with 10 −8 CFU mL −1 MRSA for 24 h (Fig.…”

Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections

“…Yang et al. ( 83 ) designed a light-triggered ZIF-8-based chemical photothermal composite ICG@ZIF-8/PDA/Ag. The composite was constructed by encapsulating the photothermal agent (PTT) ICG inside and by decorating the surface with a PDA shell and Ag.…”

Rapid In Situ Deposition of Iron-Chelated Polydopamine Coating on the Polyacrylamide Hydrogel Dressings for Combined Photothermal and Chemodynamic Therapy of Skin Wound Infection

“…These results suggested that PAM hydrogel, NIR laser irradiation and 0.5 mM H 2 O 2 had no antibacterial effect, and the photothermal effect of 150 μg/mL PDA was not enough to achieve antibacterial ability. [43][44][45]55 Compared with the PDA− PAM + NIR group, the FePDA−PAM + NIR treatment showed an obvious PTT antibacterial property (29.9%) due to the stronger absorbance and photothermal heating ability of FePDA. In the presence of H 2 O 2 , the FePDA−PAM hydrogel possessed a relatively better antibacterial effect (40.7%), which might be attributed to the ROS produced from FePDA effectively sterilizing bacteria by damaging cellular membranes, proteins, and DNA.…”

“…Fortunately, many studies have been reported on the acceleration of DA polymerization by reactive oxygen species (ROS) generated by metal ions and hydrogen peroxide (H 2 O 2 ). , It is worth noting that these transition metal ions (e.g., Fe 3+ , Cd 2+ , Cu 2+ , Ag + , Mn 2+ , Ni 2+ , etc.) can be assembled into the network structure of PDA in the polymerization process by chelating with catechol and/or imine groups − and show the Fenton or Fenton-like activity for the conversion of exogenous and endogenous H 2 O 2 to the highly toxic hydroxyl radicals ( • OH), − which can cause severe oxidative damage for chemodynamic therapy (CDT) of wound bacterial infection . For examples, Zhou et al prepared a novel divalent ion cross-linking alginate polyacrylamide hydrogel, which showed a spectrum of antibacterial activity and the ability to accelerate wound closure .…”