ICG clearance test based on photoacoustic imaging for assessment of human liver function reserve: An initial clinical study

Qiu, Tingting; Peng, Chihan; Huang, Lin; Yang, Jinge; Ling, Wenwu; Li, Jiawu; Xiang, Hongjin; Luo, Yan

doi:10.1016/j.pacs.2023.100511

Cited by 5 publications

(2 citation statements)

References 29 publications

(44 reference statements)

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“…Although PAI has been used in the clinical setting, it has mostly been adopted as a research tool to measure blood ow, oxygenation, or metabolite clearance in peripheral tissues (e.g., tumour, muscle) and the vasculature (29)(30)(31). Feto-placental imaging by PAI could be useful for monitoring fetal well-being.…”

Section: Discussionmentioning

confidence: 99%

Use of Photoacoustic Imaging to Study the Effects of Anemia on Placental Oxygen Saturation in Normoxic and Hypoxic Conditions

Noble,

Kirschenman,

Wiedemeyer

et al. 2023

Preprint

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We aimed to evaluate fetal and placental oxygen saturation (sO2) in anemic and non-anemic pregnant rats throughout gestation using photoacoustic imaging (PAI). Female Sprague Dawley rats were fed an iron-restricted or iron-replete diet before and during pregnancy. On gestational days 13, 18, and 21, PAI was coupled with high resolution ultrasound to measure oxygenation of the fetus, whole placenta, mesometrial triangle, as well as the maternal and fetal faces of the placenta. PAI was performed in 3D, which allowed sO2 to be measured within an entire region, as well as in 2D, which enabled SO2 measurements in response to a hypoxic event in real time. Both 3D and 2D PAI were performed at varying levels of FiO2 (fraction of inspired oxygen). Iron restriction caused anemia in dams and fetuses, a reduction in fetal body weight, and an increase in placental weight, but overall had minimal effects on sO2. Reductions in FiO2 caused corresponding reductions in sO2 which correlated to the severity of the hypoxic challenge. Regional differences in sO2 were evident within the placenta, and between the placenta and fetus. In conclusion, PAI enables non-invasive measurement of sO2 both rapidly and with a high degree of sensitivity. The lack of overt changes in SO2 levels between control and anemic fetuses may suggest reduced oxygen extraction and utilization in the latter group, which could be attributed to compensatory changes in growth and developmental trajectories.

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Section: Discussionmentioning

confidence: 99%

Use of Photoacoustic Imaging to Study the Effects of Anemia on Placental Oxygen Saturation in Normoxic and Hypoxic Conditions

Noble,

Kirschenman,

Wiedemeyer

et al. 2023

Preprint

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“…24 The study of diseases via medical imaging encompasses both macroscopic and microscopic aspects, as exemplified by recent research on PA imaging of liver reserve function conducted by Professor Luo Yan's team at Sichuan University. 25 The molecular imaging monitoring and synergistic technology produced by the cross-fusion of medical imaging technology and modern molecular biology is the focus and hot spot in the field of medical imaging research. Molecular imaging technology relies on the use of a molecular probe platform, 26,27 which can bind specifically to the target tissue and generate imaging signals.…”

Section: Introductionmentioning

confidence: 99%

Visualization of therapeutic intervention for acute liver injury using low-intensity pulsed ultrasound-responsive phase variant nanoparticles

Yang,

Zhang,

et al. 2024

Biomater. Sci.

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Multiplane Spectroscopic Whole‐Body Photoacoustic Computed Tomography of Small Animals In Vivo

Yang,

Choi,

Kim

et al. 2024

Laser & Photonics Reviews

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To understand complex biological process and disease progression, it is essential to comprehensively track biodynamics across entire organisms. The invaluable tracking tool, photoacoustic computed tomography (PACT), provides insights into structural, functional, and molecular aspects of living tissues. However, current small‐animal PACT systems suffer from low temporal/spatial resolution and a restricted field of view, and they are limited in the biological information they can provide, hindering research on whole‐body biodynamics. Here, it is demonstrated a continuous rotary‐scanning PACT system for rapid monitoring of various parameters within the relatively large torso of a small animal. In this PACT system, a hemispherical transducer array is continuously rotated at high speed, enabling a 3D scan of an entire mouse body in just 54 s, with a spatial resolution of 172–212 µm. The rapid rotary scanning allows us to not only image whole‐body structures but also to monitor pharmacokinetics and changes in hemoglobin oxygen saturation in living animals. This approach holds great promise for advancing the understanding of in vivo biological dynamics, opening up a new avenue of preclinical research in areas such as metabolic diseases and drug delivery.

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ICG clearance test based on photoacoustic imaging for assessment of human liver function reserve: An initial clinical study

Cited by 5 publications

References 29 publications

Use of Photoacoustic Imaging to Study the Effects of Anemia on Placental Oxygen Saturation in Normoxic and Hypoxic Conditions

Use of Photoacoustic Imaging to Study the Effects of Anemia on Placental Oxygen Saturation in Normoxic and Hypoxic Conditions

Visualization of therapeutic intervention for acute liver injury using low-intensity pulsed ultrasound-responsive phase variant nanoparticles

Multiplane Spectroscopic Whole‐Body Photoacoustic Computed Tomography of Small Animals In Vivo

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