Icetexane Diterpenoids from Perovskia atriplicifolia

Jiang, Zhi‐Yong; Yu, Yi-Jiang; Huang, Chao‐Guan; Huang, Xiang‐Zhong; Hu, Qiu‐Fen; Yang, Guang–Yu; Wang, Hongbin; Zhang, Xiangyu; Li, Gan‐Peng

doi:10.1055/s-0034-1396151

Cited by 28 publications

(37 citation statements)

References 16 publications

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“…Our previous investigation suggested that the petroleum ether extract of P . atriplicifolia showed anti‐HBV (Hepatitis B virus) activity and some bioactive chemicals had been isolated from the petroleum ether extract . But the BuOH extract showed no anti‐HBV activity during the preceding investigation.…”

Section: Introductionmentioning

confidence: 99%

Four New Diterpene Glucosides from Perovskia atriplicifolia

Zhou

Zhu

Zhang

et al. 2017

Chemistry & Biodiversity

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Four new diterpene glucosides, namely perovskiaditerpenosides A - D (1 - 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.

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Section: Introductionmentioning

confidence: 99%

Four New Diterpene Glucosides from Perovskia atriplicifolia

Zhou

Zhu

Zhang

et al. 2017

Chemistry & Biodiversity

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“…274 1α-hydroxybrussonol, a diterpinoid from Perovskia atriplicifolia suppressed the replication of hepatitis B virus DNA with selectivity index of 137.7. 275 The anti-influenza virus activity of six stilbenoids from Gnetum pendulum showed that isorhapontigenin, gnetupendin B, shegansu B, and gnetin D had significant antiinfluenza virus activity in MDCK cells, with IC50 values ranging from 0.67 to 11.99 μg/mL when compared to the positive controls oseltamivir and ribavirin with IC50 values of 0.040 and 5.54 μg/mL, respectively. 276 Tellimagrandin I, a tannin from Cornus canadensis was found effective against herpes simplex virus type 1 (HSV-1) with an EC50 of 2.6 μM for the direct mode and 5.0 μM for the absorption mode of the plaque reduction assay.…”

Section: Othersmentioning

confidence: 99%

“…277 There are several literatures documenting antiviral agents from other natural sources such as those from mushrooms, 278,279 and from marine natural products. [275][276][277][278][279][280][281][282][283]…”

Section: Othersmentioning

confidence: 99%

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Elufioye

Habtemariam

2020

TJNPR

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Coronaviruses (CoVs) are enveloped viruses that cause multiple respiratory and intestinal infections in humans and animals. 1 The term 'coronavirus' refers to the crown-like appearance of CoVs under electron microscope due to spike projections from the membrane. 2 These viruses were first described in the 1960s from patients with respiratory infections like the common cold. 3 Since then, several human coronaviruses (HCoVs) have been identified including the HCoV-Hong Kong University 1 (HKU1), HCoV-NL63; severe acute respiratory syndrome (SARS)-CoV; and Middle East respiratory syndrome (MERS)-CoV. 3 CoVs belong to the subfamilies Coronavirinae and Torovirinae of the family Coronaviridae in the order Nidovirales. 4 Based on phylogeny, they are divided into four genera as α-CoV, β-CoV, γ-CoV and δ-CoV. 5 The beta-CoV genus is further subdivided into four lineages (A, B, C, and D) 1 (Figure 1). Mammalian coronavirus include HCoV-229E and HCoV-NL63 which belong to the α-coronavirus class as well as HCoV-HKU1, SARS-CoV, MERS-CoV and HCoV-OC43 which are β-coronaviruses; while avian coronavirus is the γ-coronavirus and δ-coronavirus. 3 The novel coronavirus, 2019-nCoV, that caused the current global COVID-19 pandemic was first identified in December 2019 in the Wuhan region (Hubei Province) of China. Since then, the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses has formally designated the virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 6

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“…[ 1 2 3 ] Other compounds present in different parts of this plant include other phenolic acids, lignans, flavonoids, and di- and triterpenoids. [ 2 4 5 6 7 8 9 ] P. atriplicifolia is used as folk medicine to treat a variety of ailments, including diabetes. [ 10 11 12 ] However, the anecdotic information on the antidiabetic use of Perovskia sp.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of glycation-induced cytotoxicity, protein glycation, and activity of proteolytic enzymes by extract from Perovskia atriplicifolia Roots

Miroliaei¹,

Aminjafari²,

Ślusarczyk³

et al. 2017

Phcog Mag

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Background:Protein glycation and glycotoxicity belong to the main oxidative-stress related complications in diabetes. Perovskia species are used in Asian folk medicine as antidiabetic herbs.Objective:The aim of this study was to verify the ability of the methanolic extract from Perovskia atriplicifolia Benth. roots to diminish glycation of albumin and to prevent cell damage in vitro. Furthermore, we tested the extract for in vitro antioxidant activity and inhibition of elastase and collagenase.Material and Methods:The aqueous methanol extract was analyzed by UHPLC-MS for the content of polyphenols and terpenoids. The prevention of glycated albumin-induced cell damage was tested in four mammalian cell lines (peripheral blood mononuclear cells, human embryonic kidney cells – HEK293, normal human fibroblasts, and Chinese hamster ovary cells) with the 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazoly)-3-(4-sulfophenyl) tetrazolium assay.Results:Glycated albumin is significantly more toxic than native human serum albumin (LC50 from 35.00 to 48.34 μg/mL vs. 5.47–9.10 μg/mL, respectively). The extract, rich in rosmarinic acid (344.27 mg/g dry mass), mitigated the glycated albumin toxicity, and increased glycated albumin-treated cell survival by more than 50%. The inhibition of advanced glycation endproduct formation was confirmed by monitoring conformational changes. The free radical scavenging activity was higher than Trolox and metal reducing power was one-third to half that of ascorbic acid. The activity of elastase and collagenase was inhibited by 54.75% ± 6.87% and 60.03% ± 7.22%, respectively.Conclusions:The results confirm antiglycative and antiglycotoxic potential of Perovskia root and its traditional antidiabetic use. The high activity can be attributed to rosmarinic acid abundance.SUMMARY Perovskia is a small genus of aromatic shrubby plants growing in arid regions of Central and South Asia. Different parts are used in folk medicine as antiparasitic, anti-infectious and antidiabetic remedy. Here, we have studied the extract from roots for inhibition of: glycation-induced cytotoxicity, human serum albumin glycation, inflammation-related enzymes, as well as for antioxidant activity. Result: the extract from P. atriplicifolia roots inhibited protein glycation and AGE-induced toxicity in cell cultures. The mechanism is likely to rely on the antioxidant activity of high content of rosmarinic acid. Abbreviations used: AGE: advanced glycation end-products; DPPH: 2,2-diphenyl-1-picrylhydrazyl; HSA: human serum albumin.

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Icetexane Diterpenoids from Perovskia atriplicifolia

Cited by 28 publications

References 16 publications

Four New Diterpene Glucosides from Perovskia atriplicifolia

Four New Diterpene Glucosides from Perovskia atriplicifolia

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Inhibition of glycation-induced cytotoxicity, protein glycation, and activity of proteolytic enzymes by extract from Perovskia atriplicifolia Roots

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