ICE1: a regulator of cold-induced transcriptome and freezing tolerance in<i>Arabidopsis</i>

Chinnusamy, Viswanathan; Ohta, Masaru; Kanrar, Siddhartha; Lee, Byeong-ha; Hong, Xuhui; Agarwal, Manu; Zhu, Jian‐Kang

doi:10.1101/gad.1077503

Cited by 1,389 publications

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“…6E,F), confirming the sequence specificity of binding. Similarly, a control bHLH protein, SCRM/ICE1, which has been shown to bind in vitro to an E-box element (CANNTG) (Chinnusamy et al, 2003), did not induce any reporter activity (Fig. 6E,F).…”

Section: Research Articlementioning

confidence: 99%

Arabidopsishomeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis

et al. 2013

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SUMMARYThe shoot epidermis of land plants serves as a crucial interface between plants and the atmosphere: pavement cells protect plants from desiccation and other environmental stresses, while stomata facilitate gas exchange and transpiration. Advances have been made in our understanding of stomatal patterning and differentiation, and a set of 'master regulatory' transcription factors of stomatal development have been identified. However, they are limited to specifying stomatal differentiation within the epidermis. Here, we report the identification of an Arabidopsis homeodomain-leucine zipper IV (HD-ZIP IV) protein, HOMEODOMAIN GLABROUS2 (HDG2), as a key epidermal component promoting stomatal differentiation. HDG2 is highly enriched in meristemoids, which are transient-amplifying populations of stomatal-cell lineages. Ectopic expression of HDG2 confers differentiation of stomata in internal mesophyll tissues and occasional multiple epidermal layers. Conversely, a loss-of-function hdg2 mutation delays stomatal differentiation and, rarely but consistently, results in aberrant stomata. A closely related HD-ZIP IV gene, Arabidopsis thaliana MERISTEM LAYER1 (AtML1), shares overlapping function with HDG2: AtML1 overexpression also triggers ectopic stomatal differentiation in the mesophyll layer and atml1 mutation enhances the stomatal differentiation defects of hdg2. Consistently, HDG2 and AtML1 bind the same DNA elements, and activate transcription in yeast. Furthermore, HDG2 transactivates expression of genes that regulate stomatal development in planta. Our study highlights the similarities and uniqueness of these two HD-ZIP IV genes in the specification of protodermal identity and stomatal differentiation beyond predetermined tissue layers.

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Section: Research Articlementioning

confidence: 99%

Arabidopsishomeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis

et al. 2013

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“…In Arabidopsis, CBF1-3 are the primary cold inducible transcription factors [12,13], with AtCBF3 and AtCBF1-2 being first transcriptionally activated by ICE-1 and CAMTA, respectively [44][45][46]. There are five potential elements (myc-recognition sites, CANNTG) present in the promoter (~1kb from the ATG) of AtCBF3 [44,47] to which ICE1 could bind.…”

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“…There are five potential elements (myc-recognition sites, CANNTG) present in the promoter (~1kb from the ATG) of AtCBF3 [44,47] to which ICE1 could bind. The promoter of GmDREB1A;1 (Glyma09g27180) gene similarly has 2 and 9 myc-recognition sites within 1kbp and 1.5kbp, respectively while GmDREB1A;2 (Glyma16g32330) gene has 3 and 4 Myc-recognition sites in 1kbp and 1.5kbp, respectively.…”

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Functionality of soybean CBF/DREB1 transcription factors

Yamasaki

Randall

2016

Plant Science

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Soybean (Glycine max) is considered to be cold intolerant and is not able to significantly acclimate to cold/freezing stress. In most cold tolerant plants, the Crepeat/DRE Binding Factors (CBF/DREBs) are critical contributors to successful cold-responses; rapidly increasing following cold treatment and regulating the induction of many cold responsive genes. In soybean vegetative tissue, we found strong, transient accumulation of CBF transcripts in response to cold stress; however, the soybean transcripts of typical cold responsive genes (homologues to Arabidopsis genes such as dehydrins, ADH1, RAP2.1, and LEA14) were not significantly altered.Soybean CBFs were found to be functional, as when expressed constitutively in Arabidopsis they increased the levels of AtCOR47 and AtRD29a transcripts and increased freezing tolerance as measured by a decrease in leaf freezing damage and ion leakage. Furthermore the constitutive expression of GmDREB1A;2 and GmDREB1B;1 in Arabidopsis led to stronger up-regulation of downstream genes and more freezing tolerance than GmDREB1A;1, the gene whose transcript is the major contributor to total CBF/DREB1 transcripts in soybean. The inability for the soybean CBFs to significantly up regulate the soybean genes that contribute to cold tolerance is consistent with poor acclimation capability and the cold intolerance of soybean.

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“…22 The cold-activated HOS1 protein executes protein turnover of the INDUCER OF CBF EXPRESSION1 (ICE1) MYC-like basic helix-loop-helix (bHLH) transcription factor, 23,24 which activates the C-REPEAT BINDING FACTOR (CBF)-COLD-REGULATED (COR) pathway, 23,25,26 indicating the homeostatic role in plant adaptation to long-term cold stress. In addition to its role in cold response, the HOS1 protein also mediates plant hormone signaling.…”

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The E3 ubiquitin ligase HOS1 is involved in ethylene regulation of leaf expansion inArabidopsis

Lee

Seo

2015

Plant Signaling & Behavior

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Ethylene regulates a variety of physiological processes, such as flowering, senescence, abscission, and fruit ripening. In particular, leaf expansion is also controlled by ethylene in Arabidopsis. Exogenous treatment with ethylene inhibits leaf expansion, and consistently, ethylene insensitive mutants show increased leaf area. Here, we report that the RING finger-containing E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1) regulates leaf expansion in an ethylene signaling pathway. The HOS1-deficient mutant showed reduced leaf area and was insensitive to ethylene perception inhibitor, silver thiosulfate (STS). Accordingly, genes encoding ethylene signaling components were significantly up-regulated in hos1-3. This study demonstrates that the HOS1 protein is involved in ethylene signal transduction for the proper regulation of leaf expansion possibly under environmentally stressful conditions.Leaf expansion is a crucial process that not only determines the shape and size of mature leaves but also ensures its photosynthetic capacity for plant growth and development. 1,2 It is influenced by multiplicity of environmental factors, such as water availability and day length. 3,4 In addition, endogenous hormone signaling is also intensively involved in the control of leaf expansion. Promotive roles of auxin, brassinosteroid, and gibberellin in leaf expansion have been demonstrated. [5][6][7] The simple hydrocarbon ethylene is a gaseous plant hormone that regulates a variety of developmental processes, such as seed germination, cell elongation, abscission, senescence, sex determination, and fruit ripening. [8][9][10][11][12][13] It has been also proposed that ethylene negatively regulates leaf expansion process. Exogenous ethylene treatment results in reduced leaf area. 14 Furthermore, ethylene insensitive mutants, such as ethylene receptor 1 (etr1) and ethylene response sensor 1 (ers1), show increased leaf size. 15,16 Five receptor isoforms are responsible for ethylene perception: ETR1, ETR2, ERS1, ERS2, and ETHYLENE INSENSITIVE 4 (EIN4). 17 Their ethylene perception is integrated into a negative regulator of ethylene signaling, CONSTITUTIVE TRIPLE RESPONSE 1 (CTR1) Ser/Thr protein kinase, 18 which in turn regulates a series of transcriptional cascades in order to control ethylene-dependent physiological processes. EIN2 is a representative positive signaling regulator and subsequently activates genes encoding EIN3 and related EIN3-LIKE (EIL), which further regulate expression of ETHYLENE-RESPONSE FACTORs (ERFs). 19,20 In the presence of ethylene, ethylene receptors inactivate kinase activity of CTR1 so that subsequent transcriptional cascades are activated. 21 Although ethylene signaling pathways have been intensively investigated, its intricate networks with other signaling pathways remain to be unraveled.The RING-type E3 ligase HOS1 was originally reported as cold signaling attenuator. 22 The cold-activated HOS1 protein executes protein turnover of the INDUCER OF CBF EXPRESSION1 (ICE1) MYC-l...

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ICE1: a regulator of cold-induced transcriptome and freezing tolerance inArabidopsis

Cited by 1,389 publications

References 44 publications

Arabidopsishomeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis

Arabidopsishomeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis

Functionality of soybean CBF/DREB1 transcription factors

The E3 ubiquitin ligase HOS1 is involved in ethylene regulation of leaf expansion inArabidopsis

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