Ice water test in multiple sclerosis: A pilot trial

Hüsch, Tanja; Reitz, André; Ulm, Kurt; Haferkamp, Axel

doi:10.1111/iju.13786

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…Then, provocative tests with an increased filling rate at 100 ml/min with room temperature fluid and 4°C fluid were performed 7 . As a realization of IWT before standard cystometry can impact the findings, the same order was always used.…”

Section: Methodsmentioning

confidence: 99%

“…2 Then, provocative tests with an increased filling rate at 100 ml/min with room temperature fluid and 4°C fluid were performed. 7 As a realization of IWT before standard cystometry can impact the findings, the same order was always used. Patients were informed that the second filling would be faster, but no information was given about the fluid temperature.…”

Section: Urodynamic Assessmentmentioning

confidence: 99%

“…Moreover, the ice water test (IWT), consisting of the perfusion of 4°C fluid during cystometry, can be used to unmask DO 7 . The perception of cold sensation during IWT was described to be reduced in patients with neurological disease 8 .…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] Moreover, the ice water test (IWT), consisting of the perfusion of 4°C fluid during cystometry, can be used to unmask DO. 7 The perception of cold sensation during IWT was described to be reduced in patients with neurological disease. 8 However, the impact of cold perfusion on bladder sensations-need to void-and voiding parameters has never been studied, especially in patients with neurogenic lower urinary tract dysfunction (NLUTD) where the activation of the C-fibers is a known contributing factor in DO.…”

mentioning

confidence: 99%

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Influence of urodynamic conditions on bladder sensations and detrusor activity in patients with multiple sclerosis

Hentzen

Chesnel

Teng

et al. 2022

Neurourology and Urodynamics

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The study aimed to assess the impact of bladder filling rate and fluid temperature during urodynamics on bladder sensations and volume of apparition of detrusor overactivity in patients with multiple sclerosis (PwMS).Methods: Consecutive PwMS assessed with a standardized urodynamic test including three consecutive cystometries (20 ml/min, 100 ml/min, and 100 ml/min with 4°C fluid (Ice water test [IWT]) between June 2020 and March 2022 were included in this retrospective study. Data collected were bladder sensation with first desire to void (FDV) and strong desire to void (SDV). The presence of detrusor overactivity (DO) and the volume of the first uninhibited detrusor contraction were recorded. Results: One hundred and fifty-seven patients (mean age 47.4 ± 11.8 years, median EDSS 3 IQR[2-5], 73.9% of women) were included. Increased filling rate induced delayed bladder sensations (FDV 219 ± 109 ml vs. 194 ± 100 ml; SDV 349 ± 113 ml vs. 322 ± 124 ml for 100 ml/min and 20 ml/min filling rate, respectively, p < 0.001). Ice water increased bladder sensations with earlier reports of needs to void (FDV 163 ± 99 ml vs. 218 ± 117 ml; SDV 263 ± 104 ml vs. 351 ± 112 ml respectively; p < 0.001). Thirty-four patients had DO during both 20 ml/min and 100 ml/min fillings, without difference in the volume of apparition (p = 0.78). Forty-four patients had DO during both 100 ml/min and IWT. Detrusor overactivity appeared for a reduced volume during IWT compared with room temperature fluid perfusion (−68 ml [−95 to −41]; p < 0.001). Conclusion: Filling rate and fluid temperature impact bladder sensations during cystometry in PwMS. Ice water decreased the volume of the first uninhibited detrusor contraction.

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Section: Methodsmentioning

confidence: 99%

Section: Urodynamic Assessmentmentioning

confidence: 99%