Ice nucleation and crystallization in water-glycerol mixtures

Vigier, G.; Vassoille, R.

doi:10.1016/0011-2240(87)90038-1

Cited by 22 publications

(4 citation statements)

References 14 publications

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“…a molar W/G ratio of 2.7 (glycerol mass ratio: 0.66). It is interesting to note that this phenomenon appears to be independent of pressure (density): DTA [24] and x-ray diffraction measurements [25] at ambient pressure find that crystallization of quenched GW solutions always occurs for water contents above ≈25 wt% which corresponds approximately to the 3:1 volume fraction.…”

Section: Discussionmentioning

confidence: 98%

Freezing of glycerol–water mixtures under pressure

Klotz

Takemura

Strässle

et al. 2012

J. Phys.: Condens. Matter

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We investigated freezing of pure glycerol as well as glycerol-water (GW) mixtures with 3:1 and 3:2 volume fractions as a function of pressure in the 0-10 GPa range by ruby fluorescence spectroscopy and neutron scattering. We find that the glass transition pressure increases from 5.5 GPa for pure glycerol to 6.5 GPa for the 3:1 GW mixture, with unusually small pressure gradients above. For higher water concentrations close to 3:2, phase separation occurs above 2 GPa where most of the water is expelled in the form of ice VII. The results suggest that glycerol is able to effectively hydrogen bond not more than ≈2.5 H(2)O molecules per glycerol, which seems to support conclusions from molecular dynamics simulations. The data indicate that these fluids could become important as pressure transmitting media for neutron scattering in the 0-7 GPa range, including at low temperatures.

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Section: Discussionmentioning

confidence: 98%

Freezing of glycerol–water mixtures under pressure

Klotz

Takemura

Strässle

et al. 2012

J. Phys.: Condens. Matter

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“…This is due to the fact that the amount of crystallization which occurs may not be maximal, but reduces as a function of the cooling rate. The crystallization kinetics of CPA solutions have been studied by numerous investigators and parameters related to the formation of ice in high concentration glycerol solutions are available [81] [82] [83] [84] [85] [86] [87]. Theoretical models based on the findings are also available [88] [89].…”

Section: Numerical Predictions Of Cryobiological Applicationsmentioning

confidence: 99%

Review of biomaterial thermal property measurements in the cryogenic regime and their use for prediction of equilibrium and non-equilibrium freezing applications in cryobiology

Choi

Bischof

2010

Cryobiology

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It is well accepted in Cryobiology that the temperature history and cooling rates experienced in biomaterials during freezing procedures correlate strongly with biological outcome. Therefore, heat transfer measurement and prediction in the cryogenic regime is central to the field. Although direct measurement of heat transfer can be performed, accuracy is usually achieved only for local measurements within a given system and cannot be readily generalized to another system without the aid of predictive models. The accuracy of these models rely upon thermal properties which are known to be highly dependent on temperature, and in the case of significant cryoprotectant loading, also on crystallized fraction. In this work we review the available thermal properties of biomaterials in the cryogenic regime. The review shows a lack of properties for many biomaterials in the subzero temperature domain, and especially for systems with cryoprotective agents. Unfortunately, use of values from the limited data available (usually only down to −40 °C) lead to an underestimation of thermal property change (i.e. conductivity rise and specific heat drop due to ice crystallization) with lower temperatures. Conversely, use of surrogate values based solely on ice thermal properties lead to an overestimation of thermal property change for most biomaterials. Additionally, recent work extending the range of available thermal properties to −150 °C has shown that the thermal conductivity will drop in both PBS and tissue (liver) due to amorphous/ glassy phases (vs. ice) of biomaterials with the addition of cryoprotective additives such as glycerol. Thus, we investigated the implications of using approximated or constant property values versus measured temperature-dependent values for predicting heat transfer in PBS (phosphate buffered saline) and porcine liver with and without cryoprotectants (glycerol). Using measured property values (thermal conductivity, specific heat, and latent heat of phase change) of porcine liver, a standard was created which showed that values based on surrogate ice properties underpredicted cooling times, while constant properties (i.e. based on limited data reported near the freezing point) over-predicted cooling times. Additionally, a new iterative numerical method that accommodates non-equilibrium cooling effects as a function of time and position (i.e. crystallization vs. amorphous phase) was used to predict heat transfer in glycerol loaded systems. Results indicate that in addition to the increase in cooling times due to the lowering of thermal © 2009 Elsevier Inc. All rights reserved.Correspondence to: John C. Bischof. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors ma...

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“…Such large pores reduce the mechanical strength of the sample because they act as fracture initiation sites. In order to decrease the number and size of large pores left behind by the ice crystals that form during freeze-drying, cryoprotectants can be used to reduce the effects of solute rejection and crystallite size on the solidification of water in ceramic slurries [21,22]. In this study, we chose ethanol as a cryoprotectant, because it is nontoxic, easy to obtain, and vaporizes readily.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of highly isotropic porous alumina refractory clinkers consisting of platelets using a gelatin-sol

Muto

Hashimoto

Kondo

et al. 2020

Journal of Asian Ceramic Societies

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Porous alumina bodies are expected to find application as refractory materials to reduce energy consumption during the manufacture of inorganic products. The porosity of such bodies can be efficiently increased by using alumina platelets to form a so-called "house-ofcards" structure. This technique was employed in the present study, together with a gelatin-sol (as binder) and freeze-drying. The porosity, compressive strength, and thermal conductivity of a porous alumina body made in this manner and heat-treated at 1600°C were 80.2%, 1.7 MPa, and 0.94 W/m −1 •K −1 , respectively. These physicochemical properties would allow this alumina to be used as a thermal insulation refractory clinker material.

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Ice nucleation and crystallization in water-glycerol mixtures

Cited by 22 publications

References 14 publications

Freezing of glycerol–water mixtures under pressure

Freezing of glycerol–water mixtures under pressure

Review of biomaterial thermal property measurements in the cryogenic regime and their use for prediction of equilibrium and non-equilibrium freezing applications in cryobiology

Fabrication of highly isotropic porous alumina refractory clinkers consisting of platelets using a gelatin-sol

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