ICDM-GEHC: identifying cancer driver module based on graph embedding and hierarchical clustering
Shiyu Deng,
Jingli Wu,
Gaoshi Li
et al.
Abstract:Due to the high heterogeneity of cancers, it is rather essential to explore driver modules with the help of gene mutation data as well as known interactions between genes/proteins. Unfortunately, latent false positive interactions are inevitable in the Protein-Protein Interaction (PPI) network. Hence in the presented method, a new weight evaluation index, based on the gene-microRNA network as well as somatic mutation profile, is introduced for weighting the PPI network first. Subsequently, the vertices in the … Show more
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