ICD-10 Codes for the Study of Chronic Overlapping Pain Conditions in Administrative Databases

Schrepf, Andrew; Phan, Minh Dinh; Jq, Clemens; Maixner, William; Hanauer, David A.; Da, Williams

doi:10.1016/j.jpain.2019.05.007

Cited by 41 publications

(30 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HUNT All-In Pain Anne Heidi Skogholt 1 Ben Brumpton 1 Cristen J. Willer 2 Egil Andreas Fors 3 Ingrid Heuch 4 Jonas Bille Nielsen 1,2,5 Kjersti Storheim 6,7 Knut Hagen 8 Kristian Bernhard Nilsen 8,9…”

Section: Contributionsmentioning

confidence: 99%

“…The most common set of pain disorders that tend to overlap includes temporomandibular disorders, fibromyalgia, irritable bowel syndrome, vulvodynia, myalgic encephalomyelitis/chronic fatigue syndrome, headaches, and chronic lower back pain. This manifestation of multiple chronic pain conditions that frequently occur together and are associated with similar risk factors are referred to as chronic overlapping pain conditions (COPC), and are now recognized by the National Institute for Health (NIH) as a set of disorders that co-occur 7 . Although the pathophysiological processes that underlie most of these conditions are still poorly understood, COPC have been proposed to have common genetic, neurological, and psychological vulnerabilities.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions

Khoury

Parisien

Thompson

et al. 2021

Brain

View full text Add to dashboard Cite

Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is unknown. Using genome-wide approaches, we compared genetic determinants of chronic single-site vs. multisite pain in the UK Biobank. We found that different genetic signals underlie chronic single-site and multisite pain with much stronger genetic contributions for the latter. Among 23 loci associated with multisite pain, 9 loci replicated in the HUNT cohort, with the DCC netrin-1 receptor (DCC) as the top gene. Functional genomics identified axonogenesis in brain tissues as the major contributing pathway to chronic multisite pain. Finally, multimodal structural brain imaging analysis showed that DCC is most strongly expressed in subcortical limbic regions and is associated with alterations in the uncinate fasciculus microstructure, suggesting that DCC-dependent axonogenesis may contribute to COPC via cortico-limbic circuits.

show abstract

Section: Contributionsmentioning

confidence: 99%

mentioning

confidence: 99%

Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions

Khoury

Parisien

Thompson

et al. 2021

Brain

View full text Add to dashboard Cite

show abstract

“…However, 7 out of 27 studies in the meta‐analysis had a prevalence that was approximately the same as we found in our study ( 10 ). In addition, Schrepf et al found that the true positive rate for using ICD‐10 code for FM was 95%, giving us confidence in the use of this code ( 8 ). In addition, we found that the prevalence of migraines, CTTH, and CLBP in our study were comparable to those found in other studies ( 24 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

The Problem of Pain in Rheumatology: Clinical Profiles Associated With Concomitant Diagnoses With Chronic Overlapping Pain Conditions

Falasinnu

Nguyen

Jiang

et al. 2022

ACR Open Rheumatology

View full text Add to dashboard Cite

Objective The chronification of pain is heterogeneous in rheumatology. Chronic overlapping pain conditions (COPCs) such as fibromyalgia, endometriosis, migraine, and back pain may co‐occur with one another and in rheumatic diseases. We describe the sociodemographic and clinical profiles associated with concomitant COPCs among patients with rheumatic diseases. Methods We retrospectively identified patients visiting rheumatology clinics at a single institution from 2010 to 2020 for five common rheumatic conditions: psoriatic arthritis (PsA), rheumatoid arthritis (RA), Sjögren syndrome (SjS), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc). We compared sociodemographic, clinical, and lifestyle factors by rheumatic condition and by COPC status. We also report sex‐stratified diagnosis of COPCs. The primary outcome was diagnostic validation of one or more COPCs. Results We identified 5992 rheumatology patients: 846 with PsA, 2605 with RA, 956 with SjS, 975 with SLE, and 610 with SSc. Approximately 36–62% of patients had a concomitant COPC diagnosis. Patients with SjS had the highest prevalence (62%). Diagnosis of one or more COPCs was highest among Black patients and lowest among Asian patients. Patients using public insurance had a higher prevalence of one or more COPCs compared with those with private insurance. Patients with one or more COPCs had more depression and anxiety and more frequent emergency department visits, surgeries, and hospitalizations. Conclusion Our findings suggest that COPCs are strikingly common among patients with rheumatic disease and are associated with lower quality of life and greater health care needs. Future research may elucidate drivers of chronic pain and how to best address the unique analgesic needs of this multimorbid population.

show abstract

“…Given evidence that these fail to capture many types of chronic pain, we also created an indicator for chronic pain based on a schema deployed by Mikosz and colleagues [ 16 ], which includes ICD-10 codes for chronic non-radicular and radicular back pain, chronic neck pain, fibromyalgia, inflammatory joint disorders, irritable bowel syndrome, non-migraine headaches, osteoarthritis and joint cartilage conditions, and periarticular/soft tissue disorders. We additionally used the schema from Schrepf and colleagues to identify Chronic Overlapping Pain Conditions (COPC) [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Acute pain and self-directed discharge among hospitalized patients with opioid-related diagnoses: a cohort study

et al. 2021

View full text Add to dashboard Cite

Background Patients with substance use disorders are more likely than those without to have a self-directed hospital discharge, putting them at risk for poor health outcomes including progressing illness, readmissions, and death. Inadequate pain management has been identified as a potential motivator of self-directed discharge in this patient population. The objective of this study was to describe the association between acute pain and self-directed discharges among persons with opioid-related conditions; the presence of chronic pain in self-directed discharges was likewise considered. Methods We employed a large database of all hospitalizations at acute care hospitals during 2017 in the city of Philadelphia to identify adults with opioid-related conditions and compare the characteristics of admissions ending with routine discharge versus those ending in self-directed discharge. We examined all adult discharges with an ICD-10 diagnoses related to opioid use or poisoning and inspected the diagnostic data to systematically identify acute pain for the listed primary diagnosis and explore patterning in chronic pain diagnoses with respect to discharge outcomes. Results Sixteen percent of the 7972 admissions involving opioid-related conditions culminated in self-directed discharge, which was more than five times higher than in the general population. Self-directed discharge rates were positively associated with polysubstance use, nicotine dependence, depression, and homelessness. Among the 955 patients with at least one self-directed discharge, 15.4% had up to 16 additional self-directed discharges during the 12-month observation period. Those admitted with an acutely painful diagnosis were almost twice as likely to complete a self-directed discharge, and for patients with multiple admissions, rates of acutely painful diagnoses increased with each admission coinciding with a cascading pattern of worsening infectious morbidity over time. Chronic pain diagnoses were inconsistent for those patients with multiple admissions, appearing, for the same patient, in one admission but not others; those with inconsistent documentation of chronic pain were substantially more likely to self-discharge. Conclusions These findings underscore the importance of pain care in disrupting a process of self-directed discharge, intensifying harm, and preventable financial cost and suffering. Each admission represents a potential opportunity to provide harm reduction and treatment interventions addressing both substance use and pain.

show abstract

ICD-10 Codes for the Study of Chronic Overlapping Pain Conditions in Administrative Databases

Cited by 41 publications

References 13 publications

Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions

Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions

The Problem of Pain in Rheumatology: Clinical Profiles Associated With Concomitant Diagnoses With Chronic Overlapping Pain Conditions

Acute pain and self-directed discharge among hospitalized patients with opioid-related diagnoses: a cohort study

Contact Info

Product

Resources

About