Icariside II prevents kidney fibrosis development in chronic kidney disease by promoting fatty acid oxidation
Meng Wang,
Jing Wang,
Lingchen Wang
et al.
Abstract:Renal interstitial fibrosis (RIF) is the main pathological basis for the progression of chronic kidney disease (CKD), however, effective interventions are limited. Here, we investigated the effect of Icariside II (ICA‐II) on RIF and explored the underlying mechanisms. Rats receiving 5/6 ablation and infarction (A/I) surgery were gavaged with ICA‐II (5 or 10 mg/kg) for 8 weeks. In vitro, TGF‐β1‐stimulated NRK‐52E cells were treated with ICA‐II and (or) oleic acid, etomoxir, ranolazine, fenofibrate, and GW6471. … Show more
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