Icariin prevents cytokine‑induced β‑cell death by inhibiting NF‑κB signaling

Zhong, Shao; Ge, Jing; Yu, Jiangyi

doi:10.3892/etm.2018.6502

Cited by 8 publications

(7 citation statements)

References 63 publications

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“…ICRN (C 33 H 40 O 15 , M w = 676.67) is a type of prenylated flavonoid, showing extensive bioactivities such as antioxidant [ 44 , 45 , 46 , 47 ], neuroprotective [ 48 , 49 , 50 , 51 , 52 ], and antitumor [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] behavior as well as anti-inflammatory responses [ 62 , 63 , 64 , 65 , 66 , 67 , 68 ], and can be used to treat erectile dysfunction [ 69 , 70 , 71 , 72 ]. It appears it can improve the function of organs including bones and the heart [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ].…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

Seyedi¹,

Amiri

Mohammadzadeh

et al. 2023

JFB

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Among scaffolds used in tissue engineering, natural biomaterials such as plant-based materials show a crucial role in cellular function due to their biocompatibility and chemical indicators. Because of environmentally friendly behavior and safety, green methods are so important in designing scaffolds. A key bioactive flavonoid of the Epimedium plant, Icariin (ICRN), has a broad range of applications in improving scaffolds as a constant and non-immunogenic material, and in stimulating the cell growth, differentiation of chondrocytes as well as differentiation of embryonic stem cells towards cardiomyocytes. Moreover, fusion of ICRN into the hydrogel scaffolds or chemical crosslinking can enhance the secretion of the collagen matrix and proteoglycan in bone and cartilage tissue engineering. To scrutinize, in various types of cancer cells, ICRN plays a decisive role through increasing cytochrome c secretion, Bax/Bcl2 ratio, poly (ADP-ribose) polymerase as well as caspase stimulations. Surprisingly, ICRN can induce apoptosis, reduce viability and inhibit proliferation of cancer cells, and repress tumorigenesis as well as metastasis. Moreover, cancer cells no longer grow by halting the cell cycle at two checkpoints, G0/G1 and G2/M, through the inhibition of NF-κB by ICRN. Besides, improving nephrotoxicity occurring due to cisplatin and inhibiting multidrug resistance are the other applications of this biomaterial.

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Section: Physicochemical Propertiesmentioning

confidence: 99%

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

Seyedi¹,

Amiri

Mohammadzadeh

et al. 2023

JFB

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“…In vitro, baicalin decreased the apoptosis of the mice pancreatic β cells that were treated with TNF‐α by upregulating miR‐205 resulting in activating the PI3K/Akt pathway and inhibiting the NF‐κB pathway 129 . Icariin, a flavonoid glycoside, prevented the death of cytokine‐induced rat pancreatic β‐cell (RINm5F cells) by inhibiting NF‐κB signalling 130 . Moreover, genistein significantly decreased the incidence of T1DM in female non‐obese diabetic mice 131 .…”

Section: Flavonoids and Autoimmune Diseasesmentioning

confidence: 99%

Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

Han

Deng³

et al. 2021

Scand J Immunol

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The immune system plays an indispensable role in maintaining human health against the invasion of foreign materials, microorgainisms and pathogens. The autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation, as well as tumour, and others. In recent years, flavonoids are widely recognized as potentially natural polyphenol compounds for the treatment of multiple diseases, given their immunomodulatory activity, antioxidant and antineoplastic activities. However, the exact mechanisms of flavonoids on the immune system and inhibiting tumour remains unclear. This review article provides an overview of the impact and mechanism of flavonoids on innate and adaptive immune system through the analysis of various immune cells. Meanwhile, we also explain the probable therapeutic mechanism of flavonoids on tumour and other chronic diseases. Overall, this review may provide a certain theoretical direction and theoretical basis for the application of flavonoids in the treatment of immune‐related disorders and tumour.

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“…The quantification of the nuclear translocation of NF-κB has been established by using high-content fluorescence microscopy and imaging flow cytometry [57]. On the other hand, EMSA [37] and commercial DNA binding ELISA (such as TransAM ® NF-κB activation assays from Active Motif ® ) have been widely used to assay NF-κB activation [58][59][60][61].…”

Section: Identification Of Nf-κb In the Cnsmentioning

confidence: 99%

Challenges with Methods for Detecting and Studying the Transcription Factor Nuclear Factor Kappa B (NF-κB) in the Central Nervous System

Mostafizar

Cortes-Pérez

Snow

et al. 2021

Cells

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The transcription factor nuclear factor kappa B (NF-κB) is highly expressed in almost all types of cells. NF-κB is involved in many complex biological processes, in particular in immunity. The activation of the NF-κB signaling pathways is also associated with cancer, diabetes, neurological disorders and even memory. Hence, NF-κB is a central factor for understanding not only fundamental biological presence but also pathogenesis, and has been the subject of intense study in these contexts. Under healthy physiological conditions, the NF-κB pathway promotes synapse growth and synaptic plasticity in neurons, while in glia, NF-κB signaling can promote pro-inflammatory responses to injury. In addition, NF-κB promotes the maintenance and maturation of B cells regulating gene expression in a majority of diverse signaling pathways. Given this, the protein plays a predominant role in activating the mammalian immune system, where NF-κB-regulated gene expression targets processes of inflammation and host defense. Thus, an understanding of the methodological issues around its detection for localization, quantification, and mechanistic insights should have a broad interest across the molecular neuroscience community. In this review, we summarize the available methods for the proper detection and analysis of NF-κB among various brain tissues, cell types, and subcellular compartments, using both qualitative and quantitative methods. We also summarize the flexibility and performance of these experimental methods for the detection of the protein, accurate quantification in different samples, and the experimental challenges in this regard, as well as suggestions to overcome common challenges.

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Icariin prevents cytokine‑induced β‑cell death by inhibiting NF‑κB signaling

Cited by 8 publications

References 63 publications

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

Challenges with Methods for Detecting and Studying the Transcription Factor Nuclear Factor Kappa B (NF-κB) in the Central Nervous System

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