Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells
Xu-Yun Wang,
Wen-Jing Xu,
Bo-Nan Li
et al.
Abstract:Objective:
To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying mechanisms.
Methods:
We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and proliferation. Autophagy expression was analyzed using monodansylcadaverine staining. Immunofluorescence and Western blot analyses were used to evaluate protein expressions related to autophagy, pyroptosis, and the mTOR pa… Show more
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