Icariin improves cutaneous wound healing in streptozotocin-induced diabetic rats

Singh, Wangkheirakpam Ramdas; Sharma, Anil Kumar; Devi, Hijam Shila; Bhatia, Anjali; Patel, Madhuribahen Ratishkumar; Kumar, Dinesh

doi:10.1016/j.jtv.2021.09.004

Cited by 20 publications

(21 citation statements)

References 39 publications

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“…To further confirm the generation of neovascularization at the wound sites, immunohistochemical staining for the vascular factor CD-31 is performed. , Compared with the medical gauze group, more expression of the yellowish-brown CD-31 vascular factor can be observed in the SF/PVA-3-Cur-10 and SF/PVA-3-Cur-10 + VEGF experimental groups (Figure a). After 10 days of treatment, more secretion of vascular factors can be observed in the SF/PVA-3-Cur-10 + VEGF group, indicating that VEGF and Cur NPs can better promote neovascularization.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Curcumin-Loaded Silk Fibroin and Polyvinyl Alcohol Composite Hydrogel Films for Skin Wound Healing

Wang

Ruan

Jiang

et al. 2022

ACS Appl. Bio Mater.

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Skin regeneration of full-thickness wounds remains a challenge, requiring a well-regulated interplay of cell−cell and cell− matrix signaling. Herein, the composite hydrogel films composed of silk fibroin (SF) and polyvinyl alcohol (PVA) as scaffolds loaded with curcumin nanoparticles (Cur NPs) were developed for skin wound healing. The structure and physicochemical properties of hydrogel films were first evaluated by scanning electron microscopy (SEM), water contact angle, and chemical and mechanical measurements. In addition, the as-fabricated composite hydrogel films have a unique 3D structure and excellent biocompatibility that facilitates the adhesion and growth of cells. Antimicrobial tests in vitro showed that they could inhibit the growth of bacteria due to the incorporation of Cur NPs into composite hydrogel films. The efficacy of the curcumin-loaded SF/PVA composite hydrogel films for skin wound healing was investigated on the skin defect model in vivo. Immunological analysis showed that the as-fabricated Cur NP-loaded SF/PVA composite hydrogel films inhibited inflammation at the wound sites, while promoting angiogenesis during the wound healing process.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Curcumin-Loaded Silk Fibroin and Polyvinyl Alcohol Composite Hydrogel Films for Skin Wound Healing

Wang

Ruan

Jiang

et al. 2022

ACS Appl. Bio Mater.

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“…A balanced feed from Feed Technology Unit, IVRI was fed to the rats @ 15g/rat, twice daily throughout the study period. Before commencement of the experiment, all rats were kept in the laboratory condition for a minimum of 7 days for acclimatization [21]. The experimental protocols involved in this study were approved by the Institutional Animal Ethics Committee, Indian Veterinary Research Institute, Izatnagar, India as per permission No.…”

Section: Experimental Ratsmentioning

confidence: 99%

“…A ~ 2x2 cm 2 (400 mm 2 ) open excision wound was created on the back (dorsal thoracic region) of the rats to the depth including panniculus carnosus. Animals, after recovery from anaesthesia, were individually housed in properly disinfected cages [21].…”

Section: Wound Modelmentioning

confidence: 99%

GC-MS Analysis and Wound Healing Potential of Ficus racemosa L. Gum in Wistar Albino Rats

Patel¹,

Saddam²,

Golaviya³

et al. 2022

Act Sci VetSci

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Ficus racemosa is Ficus species plant which is popularly known as Country Fig, Udumbara and Gular. Traditionally it is use in various ailments such as ulcers, wound healing, diarrhea, stomachache and skin diseases. Skin wounds represent a major healthcare problem owing to an increasing number of trauma and pathophysiological conditions. Wound healing is a complex, well-orchestrated and regulated process consisting of series of events. Currently, available treatments are limited due to side effects and cost effectiveness. In line with that, we attempted to explore a natural source to study its potential towards the wound healing process. To the best of our knowledge, till date no documented information and published literature available reporting phytochemical profile using GC-MS (Gas chromatography and mass spectrometry) technique as well as animal studies related to healing properties of gum of F. racemosa plant. This work is the first report about the GC-MS analysis and healing potential of F. racemosa gum (FRG). GC-MS analysis of fine powder of FRG was performed by standard protocol using Perkin Elmer-Autosystem XL GC with TurboMass software which is, interfaced to MS Perkin Elmer TurboMass. GC-MS analysis identified three phytoconstituents such as, pentadecanoic acid (7.59%), hexadecyne (90.38%) and 1-undecene 9-methyl (2.04%). Then, its potential in wound healing on surgically wounded wistar rats was assessed by conducting two trials of 14 days and 24 days. During trials the wounds were visually observed, photographically documented and the wound area was measured. Results revealed that groups treated with F. racemosa gum (3%FRG and 1%FRG) showed considerable and progressive reduction in wound area (mm2) as well as significant percentage wound contraction and faster complete closure of wounds compare to control group. This study suggested that the gum of F. racemosa might be a potential therapeutic agent for skin wound healing, supporting its traditional medicinal uses.

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“…A balanced feed from Feed Technology Unit, IVRI was fed to the rats @ 15 g/rat, twice daily in morning and evening time throughout the study period. All rats were kept in the laboratory condition for a minimum of 7 days for acclimatization [9]. The experimental protocols involved in this study were approved by the Institutional Animal Ethics Committee, Indian Veterinary Research Institute, Izatnagar, India as per permission No.…”

Section: Experimental Ratsmentioning

confidence: 99%

Comparison of Wound Healing Potential of Curcumin, Alcoholic Extract and Powder of Curcuma longa L. in Rats

Patel¹,

Saddam²,

Golaviya³

et al. 2022

Act Sci VetSci

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Wound healing is an integral part of reestablishment of damaged structure. Many studies have reported that turmeric/Curcuma longa L. (C. longa) has significant anti-inflammatory, antioxidant, anti-infective and wound healing properties. Curcumin, is a one of the main active constituent of C. longa which acts on various stages of the natural wound healing process to hasten healing. In a previous study from our laboratory, it was found out that individual fractions or components and pure phytochemicals are sometimes less bioactive than crude, multicomponent extracts, i.e., most of the bioactive constituents possessing synergistic activity are lost during fractionation, isolation or processing. So, in the present study, we have compared the wound healing potential of C. longa preparations such as curcumin, C. longa alcoholic extract (CLAE) and crude C. longa rhizome powder (CLRP) in cutaneous wound model in normal rats by creating an open excision-type wound. The ointments were applied topically on the wound area twice daily for 14 days. The wound photography and contraction measurement were done on days 0, 3, 7, 11 and 14 post-wounding. Portion of granulation tissues were harvested, after euthanizing rats on 14th day, for assessment of pro-healing parameters level, oxidative parameters level and histopathological changes. The gross wound assessment revealed that among all groups, CLRP-treated groups showed greater wound contraction and faster wound closure which was followed by CLAE-treated group, curcumin and control groups. The levels of pro-healing and anti-oxidative parameters were high in treatment groups compared to control group. In histopathological study, CLRP-treated groups showed good thickness of epithelialization, marked fibroblast proliferation, angiogenesis, enhanced collagen deposition and low level of polymorph nuclear lymphocytes (PMNL) in granulation tissue compared to other groups. All treatment groups have shown faster wound healing property when compared to control group. Moreover, CLRP showed higher healing potential compared to curcumin and C. CLAE-treated groups. Therefore, findings of the present study revealed that C. longa have efficient antioxidant activities, which might have accelerated the wound healing process by preventing lipid peroxidation mediated damage to the biological structures, and by scavenging free radicals. Our findings further suggest that pure curcumin might not be the only active pharmacological moiety present in C. longa for exhibiting wound healing property.

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Icariin improves cutaneous wound healing in streptozotocin-induced diabetic rats

Cited by 20 publications

References 39 publications

Fabrication of Curcumin-Loaded Silk Fibroin and Polyvinyl Alcohol Composite Hydrogel Films for Skin Wound Healing

Fabrication of Curcumin-Loaded Silk Fibroin and Polyvinyl Alcohol Composite Hydrogel Films for Skin Wound Healing

GC-MS Analysis and Wound Healing Potential of Ficus racemosa L. Gum in Wistar Albino Rats

Comparison of Wound Healing Potential of Curcumin, Alcoholic Extract and Powder of Curcuma longa L. in Rats

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