Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway

Wu, Zhiming; Liu, Qin; Cao, Zhengliu; Li, Hui; Zhou, Yifen; Zhang, Peng

doi:10.1080/08923973.2023.2253990

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…The extracts of traditional Chinese medicines have been reported to own important regulatory functions in the treatment of RA. For instance, Icariin modulates the GAREM1/MAPK signaling pathway in RA fibroblast‐like synoviocytes to reduce cell proliferation and inflammation 15 . Genkwanin blocks the JAK/STAT and NF‐κB pathways to improve adjuvant‐stimulated arthritis 16 .…”

Section: Discussionmentioning

confidence: 99%

Forsythiaside A exhibits anti‐migration and anti‐inflammation effects in rheumatoid arthritis in vitro model

Su,

Zhou,

Huang

et al. 2023

Int J of Rheum Dis

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BackgroundRheumatoid arthritis (RA) is a kind of systemic autoimmune disease, and the joint inflammation and cartilage destruction are the major features. Some traditional Chinese medicine have been discovered to exhibit regulatory roles in the treatment of RA. Forsythiaside A (FA) as an active ingredient isolated from forsythia suspensa has been discovered to participate into the regulation of some diseases through improving inflammation. However, the regulatory effects of FA on the progression of RA keep indistinct.MethodsIL‐1β treatment (10 ng/mL) in MH7A cells was built to mimic RA in vitro (cell) model. The cell viability was examined through CCK‐8 assay. The cell proliferation was detected through Edu assay. The levels of TNF‐α, IL‐6, and IL‐8 were evaluated through ELISA. The protein expressions were measured through western blot. The cell apoptosis was assessed through flow cytometry. The cell migration and invasion abilities were tested through Transwell assay.ResultsIn this study, it was revealed that the cell proliferation was strengthened after IL‐1β treatment (p < .001), but this effect was reversed after FA treatment in a dose‐increasing manner (p < .05). Furthermore, FA suppressed inflammation in IL‐1β‐triggered MH7A cells through attenuating the levels of TNF‐α, IL‐6, and IL‐8 (p < .05). The cell apoptosis was lessened after IL‐1β treatment (p < .001), but this effect was rescued after FA treatment (p < .05). Besides, the cell migration and invasion abilities were both increased after IL‐1β treatment (p < .001), but these changes were offset after FA treatment (p < .05). Eventually, FA retarded the JAK/STAT pathway through reducing p‐JAK/JAK and p‐STAT/STAT levels (p < .01).ConclusionOur study manifested that FA exhibited anti‐migration and anti‐inflammation effects in RA in vitro model (IL‐1β‐triggered MH7A cells) through regulating the JAK/STAT pathway. This work hinted that FA can be an effective drug for RA treatment.

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Section: Discussionmentioning

confidence: 99%

Forsythiaside A exhibits anti‐migration and anti‐inflammation effects in rheumatoid arthritis in vitro model

Su,

Zhou,

Huang

et al. 2023

Int J of Rheum Dis

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Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis—Comprehensive Review

Kciuk,

Garg,

Rohilla

et al. 2024

Antioxidants

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Rheumatoid arthritis (RA) is a persistent autoimmune disorder that is characterized by joint inflammation, discomfort, and impairment. Despite the existence of several therapeutic approaches, their effectiveness is often restricted and may be linked to unfavorable side effects. Consequently, there has been growing interest in investigating naturally derived compounds as plausible therapeutic agents for RA disease. The objective of this review is to summarize the existing preclinical and clinical evidence regarding the efficacy of naturally extracted compounds and plant extracts in the treatment of RA, focusing on their anti-inflammatory, anti-oxidative, and immunomodulatory properties. Some of the problems with using natural chemicals are the uneven quality of commercially available preparations and the poor bioavailability of these compounds. Future investigations should focus on improving the formulations, conducting thorough clinical trials, and exploring different techniques to fully utilize the intrinsic potential of naturally derived chemicals in treating RA.

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Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway

Cited by 2 publications

References 29 publications

Forsythiaside A exhibits anti‐migration and anti‐inflammation effects in rheumatoid arthritis in vitro model

Forsythiaside A exhibits anti‐migration and anti‐inflammation effects in rheumatoid arthritis in vitro model

Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis—Comprehensive Review

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