Icariin attenuates the calcification of vascular smooth muscle cells through ERα – p38MAPK pathway
Jieyu He,
Yanjiao Wang,
Junkun Zhan
et al.
Abstract:ObjectiveTo investigate the relationship between icariin and the osteoblastic differentiation of vascular smooth muscle cells (VSMCs) and the signal pathway involved.MethodsWe applied a universally accepted calcification model of VSMCs induced by β glycerophosphate. Then the VSMCs calcification was observed by treatment with icariin and/or inhibitors of estrogen receptors (ERs) and p38‐mitogen‐activated protein kinase (MAPK) signaling.ResultsIcariin inhibited osteoblastic differentiation and mineralization of … Show more
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