Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway

Du, Wenjing; Tang, Zhao You; Yang, Feng; Liu, Xijun; Dong, Jingcheng

doi:10.1016/j.biopha.2021.112152

Cited by 26 publications

(12 citation statements)

References 27 publications

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“…To obtain the rat model of IPF, bleomycin was administered via direct intratracheal nebulization at 1.5 U/kg (about 50 μL/rat) by an HRH-MAG4 lung quantification nebulizer (Beijing Huironghe Technology Co., China) on day 0 and day 7, respectively. , The atomization administration method is referred to our previous article . Briefly, the rats were anesthetized and then suspended through their front incisors on an inclined bench.…”

Section: Methodsmentioning

confidence: 99%

Treatment of Idiopathic Pulmonary Fibrosis by Inhaled Silybin Dry Powder Prepared via the Nanosuspension Spray Drying Technology

Xia

Xie

et al. 2023

ACS Pharmacol. Transl. Sci.

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Idiopathic pulmonary fibrosis (IPF) is a kind of lifethreatening interstitial lung disease characterized by progressive dyspnea with accurate pathogenesis unknown. At present, heat shock protein inhibitors are gradually used to treat IPF. Silybin, a heat shock protein C-terminal inhibitor, has high safety and good application prospects. In this work, we have developed a silybin powder able to be used for inhalation administration for the treatment of IPF. Silybin powder was prepared by the spray drying method and identified using cascade impactometry, particle size, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) spectroscopy. A rat model of bleomycininduced IPF was used to assess the effect of inhaled silybin spray-dried powder. Lung hydroxyproline content, wet weight, histology, inflammatory factor expression, and gene expression were examined. The results showed that inhaled silybin spray-dried powder alleviated inflammation and fibrosis, limited hydroxyproline accumulation in the lungs, modulated gene expression in the development of IPF, and improved postoperative survival. The results of this study suggest that silybin spray-dried powder is an attractive candidate for the treatment of IPF.

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Section: Methodsmentioning

confidence: 99%

Treatment of Idiopathic Pulmonary Fibrosis by Inhaled Silybin Dry Powder Prepared via the Nanosuspension Spray Drying Technology

Xia

Xie

et al. 2023

ACS Pharmacol. Transl. Sci.

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“…Icariin is a herbal medicine extracted from the Herba Epimedii 244 . Similar to melatonin, Icariin can restrict YAP nuclear translocation by activating the Hippo pathway to reduce pulmonary fibrosis 245 . In particular, another herb, saffron yellow, can improve pulmonary fibrosis caused by paraquat 246 .…”

Section: Yap/taz and Fibrosismentioning

confidence: 99%

YAP/TAZ: Molecular pathway and disease therapy

Wei,

Hui,

Chen

et al. 2023

MedComm

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The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism signaling. YAP/TAZ influences the expressions of downstream genes and proteins as well as enzyme activity in metabolic cycles, cell proliferation, inflammatory factor expression, and the transdifferentiation of fibroblasts into myofibroblasts. YAP/TAZ can also be regulated through epigenetic regulation and posttranslational modifications. Consequently, the regulatory function of these mechanisms implicates YAP/TAZ in the pathogenesis of metabolism‐related diseases, atherosclerosis, fibrosis, and the delicate equilibrium between cancer progression and organ regeneration. As such, there arises a pressing need for thorough investigation of YAP/TAZ in clinical settings. In this paper, we aim to elucidate the signaling pathways that regulate YAP/TAZ and explore the mechanisms of YAP/TAZ‐induce diseases and their potential therapeutic interventions. Furthermore, we summarize the current clinical studies investigating treatments targeting YAP/TAZ. We also address the limitations of existing research on YAP/TAZ and propose future directions for research. In conclusion, this review aims to provide fresh insights into the signaling mediated by YAP/TAZ and identify potential therapeutic targets to present innovative solutions to overcome the challenges associated with YAP/TAZ.

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“…However, inhibition of melatonin receptors using luzindole reduced the anti-fibrotic effects induced by melatonin [69]. Icariin, another bioactive compound, was found to be effective in the inhibiting YAP functions, leading to the attenuation of bleomycin-induced PF in the rat (Table 1) [70]. Like YAP, TAZ activation was also upregulated in IPF fibroblasts [71].…”

Section: Figure 3 Role Of Yap/taz In Pulmonary Fibrosis and Regenerationmentioning

confidence: 99%

New Insights into Hippo/YAP Signaling in Fibrotic Diseases

Mia

Singh

2022

Cells

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Fibrosis results from defective wound healing processes often seen after chronic injury and/or inflammation in a range of organs. Progressive fibrotic events may lead to permanent organ damage/failure. The hallmark of fibrosis is the excessive accumulation of extracellular matrix (ECM), mostly produced by pathological myofibroblasts and myofibroblast-like cells. The Hippo signaling pathway is an evolutionarily conserved kinase cascade, which has been described well for its crucial role in cell proliferation, apoptosis, cell fate decisions, and stem cell self-renewal during development, homeostasis, and tissue regeneration. Recent investigations in clinical and pre-clinical models has shown that the Hippo signaling pathway is linked to the pathophysiology of fibrotic diseases in many organs including the lung, heart, liver, kidney, and skin. In this review, we have summarized recent evidences related to the contribution of the Hippo signaling pathway in the development of organ fibrosis. A better understanding of this pathway will guide us to dissect the pathophysiology of fibrotic disorders and develop effective tissue repair therapies.

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Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway

Cited by 26 publications

References 27 publications

Treatment of Idiopathic Pulmonary Fibrosis by Inhaled Silybin Dry Powder Prepared via the Nanosuspension Spray Drying Technology

Treatment of Idiopathic Pulmonary Fibrosis by Inhaled Silybin Dry Powder Prepared via the Nanosuspension Spray Drying Technology

YAP/TAZ: Molecular pathway and disease therapy

New Insights into Hippo/YAP Signaling in Fibrotic Diseases

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