Icariin attenuates asthmatic airway inflammation via modulating alveolar macrophage activation based on network pharmacology and in vivo experiments
Xiaofei Zhu,
Bin Wang,
Hang Yu
et al.
Abstract:BackgroundIcariin (ICA) inhibits inflammatory response in various diseases, but the mechanism underlying ICA treating airway inflammation in asthma needs further understood. We aimed to predict and validate the potential targets of ICA against asthma‐associated airway inflammation using network pharmacology and experiments.MethodsThe ovalbumin‐induced asthma‐associated airway inflammation mice model was established. The effects of ICA were evaluated by behavioral, airway hyperresponsiveness, lung pathological … Show more
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