Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes

Pu, Luya; Meng, Qingyu; Li, Shuai; Liu, Bin; Fan, Li

doi:10.1016/j.ejphar.2021.174585

Cited by 11 publications

(4 citation statements)

References 43 publications

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“…Many natural drugs can regulate the cell cycle and promote apoptosis in FLSs through the mitochondrial pathway ( 263 , 264 ). However, unlike previous findings, shikonin, icariin, and other drugs induce mitochondrial dysfunction by increasing ROS levels, decreasing mitochondrial membrane potential, and elevating the release of cytochrome C and pro-apoptotic proteins, such as caspase-3 and caspase-9, to induce apoptosis in FLSs to suppress inflammatory response ( 265 , 266 ). However, this seems to be a manifestation of drug cytotoxicity.…”

Section: Targeting Ros or Mitochondria In Ra Therapy Drugscontrasting

confidence: 78%

Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

et al. 2023

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, pannus formation, and bone and cartilage damage. It has a high disability rate. The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation and mitochondrial damage, which not only affect the metabolic processes of immune cells and pathological changes in fibroblastic synovial cells but also upregulate the expression of several inflammatory pathways, ultimately promoting inflammation. Additionally, ROS and mitochondrial damage are involved in angiogenesis and bone destruction, thereby accelerating RA progression. In this review, we highlighted the effects of ROS accumulation and mitochondrial damage on inflammatory response, angiogenesis, bone and cartilage damage in RA. Additionally, we summarized therapies that target ROS or mitochondria to relieve RA symptoms and discuss the gaps in research and existing controversies, hoping to provide new ideas for research in this area and insights for targeted drug development in RA.

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Section: Targeting Ros or Mitochondria In Ra Therapy Drugscontrasting

confidence: 78%

Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

et al. 2023

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“…Poria cocos polysaccharide enhanced the secretion of immune stimulants but inhibited the secretion of immune inhibitors, enhancing the host immune response [ 36 ]. Icariin inhibited cell proliferation by interfering with the cell cycle in RA fibroblasts, including synovial cells, promoting mitochondria-dependent apoptosis and intracellular reactive oxygen species production, which potentially improves RA outcomes [ 37 ]. Cinnamomum cassia extract had a therapeutic effect on RA, which was attributed to its antiproliferation and antimigration effects on synovial fibroblasts [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Compound Preparations Are Associated with Low Disease‐Related Complication Rates in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study of 11,074 Patients

Fang

Liu

Xin

et al. 2023

BioMed Research International

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Objective. To evaluate whether traditional Chinese medicine compound preparations (TCMCPs) are associated with rheumatoid arthritis- (RA-) related complications (including readmission, Sjogren’s syndrome, surgical treatment, and all-cause death) in patients with RA. Methods. Clinical outcome data were retrospectively collected from patients with RA discharged from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2009 to June 2021. The propensity score matching method was used to match baseline data. Multivariate analysis was conducted to analyze sex, age, the incidence of hypertension, diabetes, and hyperlipidemia and identify the risk of readmission, Sjogren’s syndrome, surgical treatment, and all-cause death. Users of TCMCP and nonusers of TCMCP were defined as the TCMCP and non-TCMCP groups, respectively. Results. A total of 11,074 patients with RA were included in the study. The median follow-up time was 54.85 months. After propensity score matching, the baseline data of TCMCP users corresponded with those of non-TCMCP users, with 3517 cases in each group. Retrospective analysis revealed that TCMCP significantly reduced clinical, immune, and inflammatory indices in patients with RA, and these indices were highly correlated. Notably, the composite endpoint prognosis for treatment failure in TCMCP users was better than that in non-TCMCP users ( HR = 0.75 (0.71-0.80)). The risk of RA-related complications in TCMCP users with high-exposure intensity ( HR = 0.669 (0.650-0.751)) and medium-exposure intensity ( HR = 0.796 (0.691-0.918)) was significantly lower than those in non-TCMCP users. An increase in exposure intensity was associated with a concomitant decrease in the risk of RA-related complications. Conclusion. The use of TCMCPs, as well as long-term exposure to TCMCPs, may lower RA-related complications, including readmission, Sjogren’s syndrome, surgical treatment, and all-cause death, in patients with RA.

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“…Icariin, kaempferol, kaempferitrin, chlorogenic acid and apigenin enhanced apoptosis and restrained proliferation of RAFLS via regulating miR-223-3p/NLRP3 signaling pathway ( Wu et al, 2020 ), cell cycle and mitochondrial pathway ( Pu et al, 2021 ), MAPK pathway ( Yoon et al, 2013 ), NF-κB pathways ( Yoon et al, 2013 ; Lou et al, 2015 ; Wang and Zhao, 2019 ), JAK/STAT pathways ( Lou et al, 2015 ) and PI3K/Akt/mTOR signaling pathway ( Sun et al, 2012 ; Wang and Zhao, 2019 ). Quercetin elevated apoptosis and decreased the migration and invasion of FLS through mitochondrial pathway and p53 phosphorylation ( Xiao et al, 2013 ), PI3K/Akt pathway ( Pan et al, 2016 ) and miR-146a/GATA6 axis ( Zhao et al, 2020 ).…”

Section: Effects On Fls Proliferation Migration and Apoptosismentioning

confidence: 99%

“…Quercetin improved impaired mitochondrial biogenesis and mitochondrial function in CIA mice via regulating the SIRT1/PGC-1α/NRF1/TFAM pathway ( Shen et al, 2021 ). In vitro studies showed that icariin and quercetin treatment induced apoptosis through mitochondrial pathway ( Xiao et al, 2013 ; Pu et al, 2021 ).…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis

Liu-bo

Yan

et al. 2022

Front. Chem.

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Rheumatoid arthritis (RA) is a chronic, progressive inflammatory and systemic autoimmune disease resulting in severe joint destruction, lifelong suffering and considerable disability. Diverse prescriptions of traditional Chinese medicine (TCM) containing Epimedii Herba (EH) achieve greatly curative effects against RA. The present review aims to systemically summarize the therapeutic effect, pharmacological mechanism, bioavailability and safety assessment of EH to provide a novel insight for subsequent studies. The search terms included were “Epimedii Herba”, “yinyanghuo”, “arthritis, rheumatoid” and “Rheumatoid Arthritis”, and relevant literatures were collected on the database such as Google Scholar, Pubmed, Web of Science and CNKI. In this review, 15 compounds from EH for the treatment of RA were summarized from the aspects of anti-inflammatory, immunoregulatory, cartilage and bone protective, antiangiogenic and antioxidant activities. Although EH has been frequently used to treat RA in clinical practice, studies on mechanisms of these activities are still scarce. Various compounds of EH have the multifunctional traits in the treatment of RA, so EH may be a great complementary medicine option and it is necessary to pay more attention to further research and development.

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Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes

Cited by 11 publications

References 43 publications

Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

Traditional Chinese Medicine Compound Preparations Are Associated with Low Disease‐Related Complication Rates in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study of 11,074 Patients

Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis

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