Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization

Wang, Guoqing; Li, Na; Wang, Xiaotang; He, Siyuan; Li, Wanqian; Wei, Fan Yan; Li, Ruonan; Liu, Jiangyi; Hou, Shengping

doi:10.1016/j.redox.2022.102297

Cited by 48 publications

(36 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In AU, the abnormal activation of microglia increase the production of inducible nitric oxide synthase ( iNOS ) which accelerates retinal degeneration and the loss of iBRB integrity, the leakage and abnormal proliferation of capillaries. In the EAU mouse model, the addition of Icariin upregulates PRDX3 which transfers the microglia phenotype from pro-inflammatory to anti-inflammatory and alleviates the state of illness ( Wang et al, 2022 ). Thereinto, PRDX3 , a primary isoform of six peroxidases in mitochondria, swiftly scavenges abnormal accumulation of H2O2 to decrease apoptosis and damage caused by oxidative stress ( Rebelo et al, 2021 ).…”

Section: Effect Of Microglia On Retinal Vasculature and Brb In Variou...mentioning

confidence: 99%

Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy

Feng

Qin

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-time and facilitate angiogenesis during retinal development. In certain retinal diseases, the activated microglia promote retinal angiogenesis in hypoxia stress through neurovascular coupling and guide neovascularization to avascular areas (e.g., the outer nuclear layer and macula lutea). Furthermore, continuously activated microglia secrete inflammatory factors and expedite the loss of the blood-retinal barrier which causes irreversible damage to the secondary death of neurons. In this review, we support microglia can be a potential cellular therapeutic target in retinopathy. We briefly describe the relevance of microglia to the retinal vasculature and blood-retinal barrier. Then we discuss the signaling pathway related to how microglia move to their destinations and regulate vascular regeneration. We summarize the properties of microglia in different retinal disease models and propose that reducing the number of pro-inflammatory microglial death and conversing microglial phenotypes from pro-inflammatory to anti-inflammatory are feasible for treating retinal neovascularization and the damaged blood-retinal barrier (BRB). Finally, we suppose that the unique properties of microglia may aid in the vascularization of retinal organoids.

show abstract

Section: Effect Of Microglia On Retinal Vasculature and Brb In Variou...mentioning

confidence: 99%

Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy

Feng

Qin

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Icariin is a type of flavonoid extracted from Epimedium and is believed to exert significant anti-inflammatory and antioxidant effects ( Wang et al, 2022a ; Wang et al, 2022b ). Hua et al (2018) reported that icariin inhibited activation of the NF-κB and MAPK pathways induced by IL-1β to suppress inflammation in degenerative NP.…”

Section: The Application Of Natural Products To Control Inflammationmentioning

confidence: 99%

Natural products can modulate inflammation in intervertebral disc degeneration

Liu

Zhu²,

Liu³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Intervertebral discs (IVDs) play a crucial role in maintaining normal vertebral anatomy as well as mobile function. Intervertebral disc degeneration (IDD) is a common clinical symptom and is an important cause of low back pain (LBP). IDD is initially considered to be associated with aging and abnormal mechanical loads. However, over recent years, researchers have discovered that IDD is caused by a variety of mechanisms, including persistent inflammation, functional cell loss, accelerated extracellular matrix decomposition, the imbalance of functional components, and genetic metabolic disorders. Of these, inflammation is thought to interact with other mechanisms and is closely associated with the production of pain. Considering the key role of inflammation in IDD, the modulation of inflammation provides us with new options for mitigating the progression of degeneration and may even cause reversal. Many natural substances possess anti-inflammatory functions. Due to the wide availability of such substances, it is important that we screen and identify natural agents that are capable of regulating IVD inflammation. In fact, many studies have demonstrated the potential clinical application of natural substances for the regulation of inflammation in IDD; some of these have been proven to have excellent biosafety. In this review, we summarize the mechanisms and interactions that are responsible for inflammation in IDD and review the application of natural products for the modulation of degenerative disc inflammation.

show abstract

“…Specifically, M1 phenotype microglia causes neuronal damage by releasing proinflammatory mediators. On the contrary, M2 phenotype microglia release anti-inflammatory mediators, thereby exerting beneficial effects [ 12 , 13 , 14 ]. Thus, promoting microglial activation toward the M2 phenotype appears to be a meaningful strategy for POCD treatment.…”

Section: Introductionmentioning

confidence: 99%

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery

et al. 2023

View full text Add to dashboard Cite

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy due to its unclear pathogenesis. Caffeic acid phenethyl ester (CAPE), which is obtained from honeybee propolis and medicinal plants, shows powerful antioxidant, anti-inflammatory, and immunomodulating properties. In this study, we aimed to evaluate whether CAPE mitigated cognitive impairment following anesthesia and surgery and its potential underlying mechanisms in aged mice. Here, isoflurane anesthesia and tibial fracture surgery were used as the POCD model, and H2O2-induced BV2 cells were established as the microglial oxidative stress model. We revealed that CAPE pretreatment suppressed oxidative stress and promoted the switch of microglia from the M1 to the M2 type in the hippocampus, thereby ameliorating cognitive impairment caused by anesthesia and surgery. Further investigation indicated that CAPE pretreatment upregulated hippocampal Sirt6/Nrf2 expression after anesthesia and surgery. Moreover, mechanistic studies in BV2 cells demonstrated that the potent effects of CAPE pretreatment on reducing ROS generation and promoting protective polarization were attenuated by a specific Sirt6 inhibitor, OSS_128167. In summary, our findings opened a promising avenue for POCD prevention through CAPE pretreatment that enhanced the Sirt6/Nrf2 pathway to suppress oxidative stress as well as favor microglia protective polarization.

show abstract

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization

Cited by 48 publications

References 31 publications

Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy

Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy

Natural products can modulate inflammation in intervertebral disc degeneration

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery

Contact Info

Product

Resources

About