ICAM1 Is a Potential Cancer Stem Cell Marker of Esophageal Squamous Cell Carcinoma

Tsai, Sheng Ta; Wang, Po Jen; Liou, Nia Jhen; Lin, Pei Shan; Chen, Chung Hsuan; Chang, Wei Chao

doi:10.1371/journal.pone.0142834

Cited by 52 publications

(39 citation statements)

References 47 publications

(40 reference statements)

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“…We also identified that CD54 + prostate cancer cells show characteristics of CSCs both in vitro and in vivo . Recent studies also showed that CD54 is a potential CSC marker of esophageal squamous cell carcinoma 44, glioblastoma 45, and prostate cancer 45. Together, these data suggested that CD54 was a reliable marker for CSCs.…”

Section: Discussionmentioning

confidence: 83%

CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer

Liu

Yan

et al. 2017

Theranostics

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Cancer stem cells (CSCs) are considered one of the key contributors to chemoresistance and tumor recurrence. Therefore, the precise identification of reliable CSC markers and clarification of the intracellular signaling involved in CSCs remains a great challenge in fields relating to cancer biology. Here, we implemented a novel chemoresistant prostate cancer patient-derived xenograft (PDX) model in NOD/SCID mice and identified CD54 as a candidate gene among the most highly enriched gene expression profiles in prostate tumors exposed to chronic cisplatin administration. Additional in vitro and in vivo assays showed that CD54 played a critical role in the self-renewal and tumorigenesis of prostate CSCs. Moreover, silencing CD54 greatly reduced the tumorigenesis of prostate cancers both in vitro and in vivo and significantly extended the survival time of tumor-bearing mice in a prostate cancer xenograft model. Dissection of the molecular mechanism revealed that the p38-Notch1 axis was the main downstream signaling pathway in CD54-mediated regulation of CSCs in prostate cancers. Together, these results established that CD54 could be a novel reliable prostate CSC marker and provided a new potential therapeutic target in prostate cancer via CD54-Notch1 signaling.

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Section: Discussionmentioning

confidence: 83%

CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer

Liu

Yan

et al. 2017

Theranostics

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“…Reduced expression of ICAM-1 could play a role in the suppression of tumor progression in many cancer cells, such as breast cancer (Ogawa et al, 1998), gastric cancer (Fujihara et al, 1999), lung cancer (Kotteas et al, 2014) and colorectal cancer (Maeda et al, 2002). Additionally, ICAM1 and CD44 may have compensatory effects to maintain the dry characteristics of esophageal squamous cell carcinoma, indicating multiple targeted therapies that can be combined and considered in cancer treatment (Tsai et al, 2015). Research has demonstrated that ICAM1 is involved in angiogenesis through the regulation of endothelial cell migration (Kevil et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of HELLS (Helicase, Lymphoid-Specific) and ICAM1 (Intercellular adhesion molecule 1) as potential diagnostic biomarkers of lung cancer

Zhu

Songyang

et al. 2020

PeerJ

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Although lung cancer is one of the greatest threats to human health, its signaling pathway and related genes are still unknown. This study integrates data from three groups of people to study potential key candidate genes and pathways related to lung cancer. Expression profiles (GSE18842, GSE19188 and GSE27262), including 162 tumor tissue and 135 adjacent normal lung tissue samples, were integrated and analyzed. Differentially expressed genes (DEGs) and candidate genes were identified, their expression pathways were analyzed, and the diethylene glycol-related protein–protein interaction (PPI) network was analyzed. We identified 232 shared DEGs (40 upregulated and 192 down-regulated) from the three GSE datasets. The DEGs were clustered according to function and signaling pathway for significant enrichment analysis. In total, 129 nodes/DEGs were identified from the DEG PPI network complex. An improved prognosis was associated with increased Helicase, Lymphoid-Specific (HELLS) and decreased Intercellular adhesion molecule 1 (ICAM1) mRNA expression in lung cancer patients. In conclusion, we used integrated bioinformatics analysis to identify candidate genes and pathways in lung cancer to show that HELLS and ICAM1 might be the key genes related to tumorigenesis or tumor progression in lung cancer. Additional studies are needed to further explore the involved functional mechanisms.

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“…ICAM1, a member of the immunoglobulin superfamily (IGSF), is an important adhesion molecule (24) involved in cell metastasis, differentiation and proliferation. Recently, ICAM1 was reported to serve as a liver cancer and ESCC stem cell marker (25,26); it can also promote ESCC epithelial-to-mesenchymal transition (EMT) (27) and cause metastasis of ESCC cells by regulating the expression of tumor metastasis-related genes, such as P53 (26). We predicted the possible role of ICAM1 as a target gene for lncRNA-ECM according to bioinformatics analysis.…”

Section: Discussionmentioning

confidence: 99%

LncRNA‑ECM is overexpressed in esophageal squamous cell carcinoma and promotes tumor metastasis

Yao

Shen

et al. 2018

Oncol Lett

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Abstract. The aim of the present study was to investigate the expression of long non-coding(lnc) RNA-extracellular matrix (ECM) in esophageal squamous cell carcinoma (ESCC) and its effect on ESCC metastasis. Using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), the expression of lncRNA-ECM in ESCC tissues was investigated and compared with that in corresponding adjacent tissues. In addition, the expression of lncRNA-ECM in the human ESCC cell lines TE-1, EC9706, KYSE150, Eca109 and KYSE30 was also detected and compared with that in the normal esophageal mucosal epithelial cell line HET-1A. The clinicopathological association between lncRNA-ECM and ESCC was assessed. Silencing and overexpression of lncRNA-ECM in ESCC TE-1 and Eca109 cells determined the correlation between lncRNA-ECM expression and ESCC invasion and metastasis. The possible target genes of lncRNA-ECM were predicted and verified by bioinformatics analysis and experimental results. The expression level of intercellular adhesion molecule 1 (ICAM1) was detected in ESCC tissues by RT-qPCR and the correlation between the expression of ICAM1 and lncRNA-ECM was analyzed. Changes in the expression of ICAM1 in ESCC TE-1 and Eca109 cell lines were evaluated after knocking down lncRNA-ECM and transfection of lncRNA-ECM overexpression plasmids. The expression level of lncRNA-ECM in the tissues of ESCC with lymph node metastasis were significantly increased compared with ESCC with no lymph metastasis (P<0.05). LncRNA-ECM silencing notably reduced the invasion and metastasis of TE-1 and Eca109 cells, while lncRNA-ECM overexpression promoted the invasion and metastasis of the two cell lines. The expression level of ICAMI was directly correlated with the expression of lncRNA-ECM, suggesting that ICAM1 may be the downstream target gene of lncRNA-ECM. LncRNA-ECM was revealed as being overexpressed in ESCC. LncRNA-ECM expression was positively correlated with metastasis and may affect the metastasis of ESCC through ICAMI regulation. These findings indicate that lncRNA-ECM may be promising as a novel biomarker for the diagnosis and prediction of prognosis for ESCC, and it may also serve as a novel therapeutic target for ESCC. IntroductionEsophageal cancer is one of the most common malignancies, with an incidence rate that ranks sixth in China and fourth among the causes of cancer-related mortality (1). Esophageal cancer is also one of the most common lethal tumors worldwide with the sixth highest mortality rate (2). Esophageal squamous cell carcinoma (ESCC) accounts for >90% of the cases of esophageal cancer, and has a high degree of aggressiveness and complexity of biological behavior, making its clinical course variable and heterogeneous. A considerable number of ESCC patients have already metastasized at diagnosis. The metastasis of ESCC is the main cause of poor prognosis and mainly involves lymph node and distant metastasis (3). Previous studies demonstrated that the 5-year survival rate of ESCC patients without metastasis was 70-92%, whe...

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ICAM1 Is a Potential Cancer Stem Cell Marker of Esophageal Squamous Cell Carcinoma

Cited by 52 publications

References 47 publications

CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer

CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer

Identification and validation of HELLS (Helicase, Lymphoid-Specific) and ICAM1 (Intercellular adhesion molecule 1) as potential diagnostic biomarkers of lung cancer

LncRNA‑ECM is overexpressed in esophageal squamous cell carcinoma and promotes tumor metastasis

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