ICAM-1-related noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling

Ding, Shuangjin; Liu, Jiankun; Han, Xianlin; Ding, Wanqiu; Liu, Zhirui; Zhu, Ying; Zhan, Wenxing; Wan, Yiqi; Gai, Shujie; Hou, Junjie; Wang, Xiaoxia; Wu, Yixia; Wu, Andong; Li, Chuan-Yun; Zheng, Zhe; Tian, Xiao-Li

doi:10.1016/j.yjmcc.2022.06.001

Cited by 8 publications

(5 citation statements)

References 45 publications

(48 reference statements)

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“…As the expression of miR-17-3p is itself induced by TNF-α via NF-κB, the study provided an elegant demonstration of ICAM-1 post-transcriptional regulation by miRNA-mediated negative feedback. Additional studies have implicated numerous regulatory RNAs in the post-transcriptional regulation of ICAM-1 expression in various contexts, including miR-126-3p in the context of IL-6 stimulation [49]; miR-150-5p in acute respiratory distress syndrome [50] and allergic rhinitis [51], miR-223 in Kawasaki disease [52,53] and sepsis [54], miR148b-3p in coronary artery disease [55], and ICAM-1 related long non-coding RNA (ICR) in atherosclerosis [56], retinal vasculopathy [57], and hepatocellular carcinoma [58].…”

Section: Post-transcriptional Regulationmentioning

confidence: 99%

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Haydinger

Ashander

Tan

et al. 2023

Biology

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Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein in the immunoglobulin superfamily expressed on the surface of multiple cell populations and upregulated by inflammatory stimuli. It mediates cellular adhesive interactions by binding to the β2 integrins macrophage antigen 1 and leukocyte function-associated antigen 1, as well as other ligands. It has important roles in the immune system, including in leukocyte adhesion to the endothelium and transendothelial migration, and at the immunological synapse formed between lymphocytes and antigen-presenting cells. ICAM-1 has also been implicated in the pathophysiology of diverse diseases from cardiovascular diseases to autoimmune disorders, certain infections, and cancer. In this review, we summarize the current understanding of the structure and regulation of the ICAM1 gene and the ICAM-1 protein. We discuss the roles of ICAM-1 in the normal immune system and a selection of diseases to highlight the breadth and often double-edged nature of its functions. Finally, we discuss current therapeutics and opportunities for advancements.

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Section: Post-transcriptional Regulationmentioning

confidence: 99%

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Haydinger

Ashander

Tan

et al. 2023

Biology

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“…Interestingly, long non-coding RNAs (lncRNAs) were a class of transcripts detected in several of our cohorts. While it has proven difficult to identify bona fide orthologs of specific lncRNAs across species, it is clear these genes play crucial roles in the homeostasis of the vascular system ( Li et al, 2020 ; Ding et al, 2022 ; Tang et al, 2022 ) and our data would support a role for them in response to dietary perturbations either in utero or post-natally. As RNA structural predictions improve, it may be possible to link established lncRNA in mouse or human with those observed in our study.…”

Section: Discussionmentioning

confidence: 70%

Development of a novel Guinea Pig model producing transgenerational endothelial transcriptional changes driven by maternal food restriction and a second metabolic insult of high fat diet

Le,

Hagen,

Louey

et al. 2023

Front. Physiol.

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Developmental programming of chronic adverse cardiovascular health outcomes has been studied both using numerous human populations and an array of animal models. However, the mechanisms that produce transgenerational effects have been difficult to study due to a lack of developmentally relevant models. As such, how increased disease risk is carried to the second generation has been poorly studied. We hypothesized that the endothelium which mediates many acute and chronic vascular inflammatory responses is a key player in these effects, and epidemiological studies implicate transgenerational nutritional effects on endothelial health. To study the mutigenerational effects of maternal undernutrition on offspring endothelial health, we developed a model of transgenerational nutritional stress in guinea pigs, a translationally relevant precocial species with a relatively short lifespan. First- and second-generation offspring were subjected to a high fat diet in adolescence to exacerbate negative cardiovascular health. To assess transcriptional changes, we performed bulk RNA-sequencing in carotid artery endothelial cells, with groups stratified as prenatal control or food restricted, and postnatal control or high fat diet. We detected statistically significant gene alterations for each dietary permutation, some of which were unique to treatments and other transcriptional signatures shared by multiple or all conditions. These findings highlight a core group of genes altered by high fat diet that is shared by all cohorts and a divergence of transgenerational effects between the prenatal ad libitum and dietary restriction groups. This study establishes the groundwork for this model to be used to better understand the interplay of prenatal stress and genetic reprogramming.

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“…This is in agreement with Li et al (2022). They discovered that the anti-oxidative effects of melatonin in heart failure were mostly independent of its ejection fraction and that its use reduced lipid peroxidation and controlled the activities of both enzymatic and non-enzymatic antioxidant mechanisms [19,20].…”

Section: Resultsmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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ICAM-1-related noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling

Cited by 8 publications

References 45 publications

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Development of a novel Guinea Pig model producing transgenerational endothelial transcriptional changes driven by maternal food restriction and a second metabolic insult of high fat diet

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