Ic‐p‐183: Employing Early Uptake Data From F18‐florbetapir Scans as an Estimate of Regional Cerebral Blood Flow: Comparison to F18‐fdg

Devous, Michael D.; Joshi, Abhinay D.; Kennedy, Ian; Navitsky, Michael; Pontecorvo, Michael J.; Skovronsky, Daniel J.; Mintun, Mark A.

doi:10.1016/j.jalz.2014.05.190

Cited by 6 publications

(3 citation statements)

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“…In addition, 11 C-PiB delivery was generally independent of retention, lending further support for determining dual-imaging measures from dynamic 11 C-PiB imaging. Lastly, despite flow independence for cross-sectional 11 C-PiB retention, a recent report by van Berckel et al describes how longitudinal 11 C-PiB SUVR can be sensitive to longitudinal flow changes (e.g., cortical flow change when reference flow is stable), and this is important to consider and better understand in future studies (20), including those performed with 18 F-labeled Aβ PET imaging agents (37,38). …”

Section: Discussionmentioning

confidence: 99%

Relative ¹¹C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session ¹⁵O-Water and ¹¹C-PiB PET

et al. 2015

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The primary goal of this study was to assess the suitability of 11C-Pittsburgh compound B (11C-PiB) blood–brain barrier delivery (K1) and relative delivery (R1) parameters as surrogate indices of cerebral blood flow (CBF), with a secondary goal of directly examining the extent to which simplified uptake measures of 11C-PiB retention (amyloid-β load) may be influenced by CBF, in a cohort of controls and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). Methods Nineteen participants (6 controls, 5 AD, 8 MCI) underwent MR imaging, 15O-water PET, and 11C-PiB PET in a single session. Fourteen regions of interest (including cerebellar reference region) were defined on MR imaging and applied to dynamic coregistered PET to generate time–activity curves. Multiple analysis approaches provided regional 15O-water and 11C-PiB measures of delivery and 11C-PiB retention that included compartmental modeling distribution volume ratio (DVR), arterial- and reference-based Logan DVR, simplified reference tissue modeling 2 (SRTM2) DVR, and standardized uptake value ratios. Spearman correlation was performed among delivery measures (i.e., 15O-water K1 and 11C-PiB K1, relative K1 normalized to cerebellum [Rel-K1-Water and Rel-K1-PiB], and 11C-PiB SRTM2-R1) and between delivery measures and 11C-PiB retention, using the Bonferroni method for multiple-comparison correction. Results Primary analysis showed positive correlations (ρ ≈0.2–0.5) between 15O-water K1 and 11C-PiB K1 that did not survive Bonferroni adjustment. Significant positive correlations were found between Rel-K1-Water and Rel-K1-PiB and between Rel-K1-Water and 11C-PiB SRTM2-R1 (ρ ≈0.5–0.8, P < 0.0036) across primary cortical regions. Secondary analysis showed few significant correlations between 11C-PiB retention and relative 11C-PiB delivery measures (but not 15O-water delivery measures) in primary cortical areas that arose only after accounting for cerebrospinal fluid dilution. Conclusion 11C-PiB SRTM2-R1 is highly correlated with regional relative CBF, as measured by 15O-water K1 normalized to cerebellum, and cross-sectional 11C-PiB retention did not strongly depend on CBF across primary cortical regions. These results provide further support for potential dual-imaging assessments of regional brain status (i.e., amyloid-β load and relative CBF) through dynamic 11C-PiB imaging.

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Section: Discussionmentioning

confidence: 99%

Relative ¹¹C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session ¹⁵O-Water and ¹¹C-PiB PET

et al. 2015

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“…Similar to [11C]‐PIB, CBF has been associated with the early uptake of florbetapir, another amyloid PET tracer . Thus, it is possible that our techniques with [ 11 C]‐PIB could be applied to other amyloid tracers, which may broaden the research and clinical implications of these findings once replicated and validated.…”

Section: Discussionmentioning

confidence: 86%

Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment

Brown

Rashidi‐Ranjbar

Caravaggio

et al. 2019

Journal of Neuroimaging

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BACKGROUND AND PURPOSE: Amyloid deposition, tau neurofibrillary tangles, and cerebrovascular dysfunction are important pathophysiologic features in Alzheimer's disease. Pittsburgh compound B ([ 11 C]-PIB) is a positron emission tomography (PET) radiotracer used to quantify amyloid deposition in vivo. In addition, certain models of [ 11 C]-PIB delivery reflect cerebral blood flow rather than amyloid plaques. As cerebral blood flow and perfusion deficits are associated with white matter pathology, we hypothesized that [ 11 C]-PIB delivery in white matter regions may reflect white matter integrity. METHODS: We obtained [ 11 C]-PIB-PET scans and quantified white matter hyperintensities and global fractional anisotropy on magnetic resonance images as biomarkers of white matter pathology in 34 older participants with mild cognitive impairment with or without a history of major depressive disorder. We analyzed the [ 11 C]-PIB time-activity curve data with models associated with cerebral blood flow: the early maximum standard uptake value and the relative delivery parameter R1. We used a global white matter region of interest. RESULTS:Both of the partial-volume corrected PET parameters were correlated with white matter hyperintensities and fractional anisotropy. CONCLUSION:Future studies are warranted to explore whether [ 11 C]-PIB PET is a "triple biomarker" that may provide information about amyloid deposition, cerebral blood flow, and white matter pathology.

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“…A pilot sub‐study to acquire early frames PET data from 18 F‐florbetapir PET scans was included in ADNI 2. This comprised cross‐sectional data only but enabled observation of the anticipated close relationship between “early frames”‐based hypoperfusion and hypometabolism from 18 F‐FDG PET 24 . However, to be used as an outcome biomarker in clinical trials, the longitudinal measurement characteristics of the early frames amyloid PET signal require characterization.…”

Section: Pet Endpoints Working Groupmentioning

confidence: 99%

The Alzheimer's Disease Neuroimaging Initiative and the role and contributions of the Private Partners Scientific Board (PPSB)

Albala,

Appelmans,

Burress

et al. 2023

Alzheimer's & Dementia

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The Alzheimer's Disease Neuroimaging Initiative (ADNI) Private Partners Scientific Board (PPSB) encompasses members from industry, biotechnology, diagnostic, and non‐profit organizations that have until recently been managed by the Foundation for the National Institutes of Health (FNIH) and provided financial and scientific support to ADNI programs. In this article, we review some of the major activities undertaken by the PPSB, focusing on those supporting the most recently completed National Institute on Aging grant, ADNI3, and the impact it has had on streamlining biomarker discovery and validation in Alzheimer's disease. We also provide a perspective on the gaps that may be filled with future PPSB activities as part of ADNI4 and beyond.Highlights The Private Partners Scientific board (PPSB) continues to play a key role in enabling several Alzheimer's Disease Neuroimaging Initiative (ADNI) activities. PPSB working groups have led landscape assessments to provide valuable feedback on new technologies, platforms, and methods that may be taken up by ADNI in current or future iterations.

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Ic‐p‐183: Employing Early Uptake Data From F18‐florbetapir Scans as an Estimate of Regional Cerebral Blood Flow: Comparison to F18‐fdg

Cited by 6 publications

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Relative ¹¹C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session ¹⁵O-Water and ¹¹C-PiB PET

Relative ¹¹C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session ¹⁵O-Water and ¹¹C-PiB PET

Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment

The Alzheimer's Disease Neuroimaging Initiative and the role and contributions of the Private Partners Scientific Board (PPSB)

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Ic‐p‐183: Employing Early Uptake Data From F18‐florbetapir Scans as an Estimate of Regional Cerebral Blood Flow: Comparison to F18‐fdg

Cited by 6 publications

References 0 publications

Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET

Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET

Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment

The Alzheimer's Disease Neuroimaging Initiative and the role and contributions of the Private Partners Scientific Board (PPSB)

Contact Info

Product

Resources

About

Relative ¹¹C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session ¹⁵O-Water and ¹¹C-PiB PET

Relative ¹¹C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session ¹⁵O-Water and ¹¹C-PiB PET