IC‐P‐033: Resting‐State Network Dysfunction in Alzheimer’s Disease: A Systematic Review and Meta‐Analysis

Abstract

Introduction: We performed a systematic review and meta-analysis of the Alzheimer's disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment, using resting-state functional magnetic resonance imaging. Methods: Studies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies. Results: Thirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and limbic networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific examination of the default mode network. Discussion: Convergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD. The locations of consistent alterations suggest that highly connected hub regions in the brain might be an early target of AD.

Functional connectivity and mild behavioral impairment in dementia‐free elderly

“…FC disruptions within specific brain RSNs have been implicated in cognitive and neuropsychiatric manifestations of AD dementia and could serve as putative biomarkers for early detection. Specifically, FC disruptions within the default mode network (DMN) and salience network (SN) have been reported in both early‐onset and late‐onset AD 11 . The DMN includes the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and lateral inferior parietal cortex (LIP) 12 .…”

“…Specifically, FC disruptions within the default mode network (DMN) and salience network (SN) have been reported in both early-onset and late-onset AD. 11 The DMN includes the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and lateral inferior parietal cortex (LIP). 12 The SN includes the anterior cingulate cortex (ACC), anterior insula (AI), supramarginal gyrus (SMG), and rostral prefrontal cortex (RPFC).…”

Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents

“…Previous evidence has shown brain regions exhibiting excessive tau accumulation coalesce into 10 tau pathology networks, which have been associated with clinical outcomes, such as disease stage and global cognition dysfunction, and with segments of several well-established functional networks, such as default mode network and language network (Hoenig et al, 2018). Examining the connections among regions susceptible to accumulate the tau protein is particularly important given that AD seems to affect several higher-order cognitive networks (Badhwar et al, 2017) but is not specific to any large-scale functional brain network as a whole (Hansson et al, 2017). This might be partially explained by regional differences in the vulnerability to tau accumulation (Hansson et al, 2017).…”

Quantitative Assessment of Resting‐State Functional Connectivity MRI to Differentiate Amnestic Mild Cognitive Impairment, Late‐Onset Alzheimer's Disease From Normal Subjects

“…In several studies, FC is considered an indicator for diagnosing AD-related cognitive decline. 4,5 However, studies on FC alteration in the resting-state brain network of AD and aMCI patients are limited, and findings are inconsistent. 6 This inconsistency may be due to different data acquisition and analysis methods and considering different areas of the brain.…”