1987
DOI: 10.1016/0378-5173(87)90024-x
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Ibuprofen-polyvinylpyrrolidone dispersions. Proton nuclear magnetic resonance and infrared studies

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Cited by 24 publications
(11 citation statements)
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“…Zografi and co-workers 17 have concluded that low levels of poly(vinylpyrrolidone) which inhibit amorphous indomethacin crystallization must act through additional factors not related to glass transition events and molecular mobility but perhaps relate to specific chemical and steric interactions. Thus in a manner similar to the hydrogen bonding complexes known to occur in ibuprofen-poly(vinylpyrrolidone) solid dispersions, 18 specific protein-excipient interactions could inhibit crystallization. It is also possible that the distribution of protein and excipient within a particle is not homogeneous and thus the protein may be preferentially located at sites to inhibit nucleation and growth.…”
Section: Resultsmentioning
confidence: 97%
“…Zografi and co-workers 17 have concluded that low levels of poly(vinylpyrrolidone) which inhibit amorphous indomethacin crystallization must act through additional factors not related to glass transition events and molecular mobility but perhaps relate to specific chemical and steric interactions. Thus in a manner similar to the hydrogen bonding complexes known to occur in ibuprofen-poly(vinylpyrrolidone) solid dispersions, 18 specific protein-excipient interactions could inhibit crystallization. It is also possible that the distribution of protein and excipient within a particle is not homogeneous and thus the protein may be preferentially located at sites to inhibit nucleation and growth.…”
Section: Resultsmentioning
confidence: 97%
“…However, carbonyl group is more favorable due to the steric hindrance effect on the nitrogen atom[33]. Thus, any sign of interaction would be reflected by band shifts, broadening, disappearance of peaks or intensity alterations as compared to the spectra of the pure drug and polymers[3435]. …”
Section: Resultsmentioning
confidence: 99%
“…The interactions between the components were studied using infrared spectroscopy and nuclear magnetic resonance (NMR) techniques, and the idea of strong interactions between the two components being important for amorphous formulation performance was introduced ( 15 ). In the same year, El-Hinnawi and Hajib used the same techniques for studying amorphous ibuprofen-PVP ( 16 ). Both these publications indicated that the systems studied were actually “glass solutions”, but in the publications, the authors used the general term “solid dispersion”.…”
Section: Introductionmentioning
confidence: 99%