Ibuprofen Plus Prostaglandin E1 in a Septic Porcine Model of Adult Respiratory Distress Syndrome

Ea, Davies; rd, Campbell Aj; Mj, Devine; Sm, Steinberg; Ct, Cloutier

doi:10.1097/00005373-198903000-00002

Cited by 15 publications

(2 citation statements)

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“…In the lung, endotoxemia, aspiration pneumonia or exposure to an elevated concentration of oxygen induces serious pathologic inflammatory reactions, such as acute lung injury (ALI) or adult respiratory distress syndrome (ARDS). The pathogenesis of ALI or ARDS has not been fully clarified, but it is suggested that excessive accumulation of activated neutrophils and release of oxygen radicals, proteinases and arachidonic acid derivatives from the cells are crucial to the pathophysiology of the diseases (1). To ameliorate the lung injury, trials to regulate activity of oxygen radicals and arachidonic acid derivatives have been successfully conducted (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of ALI or ARDS has not been fully clarified, but it is suggested that excessive accumulation of activated neutrophils and release of oxygen radicals, proteinases and arachidonic acid derivatives from the cells are crucial to the pathophysiology of the diseases (1). To ameliorate the lung injury, trials to regulate activity of oxygen radicals and arachidonic acid derivatives have been successfully conducted (1,2). The outcomes of ALI and ARDS have improved, but the mortality rate is still high (3).…”

Section: Introductionmentioning

confidence: 99%

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et al. 1999

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The selectin family adhesion molecules exert a crucial role in accumulation of leukocytes at the site of inflammation. To test the biological effects of soluble selectin on lung inflammation, we introduced an expression plasmid vector of soluble selectin gene via HVJ-liposome into a murine model of LPS-induced lung injury. The myeloperoxidase activity in LPS-injected mice was suppressed by the in vivo injection of soluble P-selectin gene relative to control mice. On the contrary, soluble E- or L-selectin genes did not exert suppressive effects. Our observations suggest that P-selectin plays a crucial role in the initial steps of lung inflammation, and exogenous introduction of soluble P-selectin by in vivo gene transfer method may be a useful strategy for regulating inflammation of the lung.

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Section: Introductionmentioning

confidence: 99%