Ibuprofen-Cyclodextrin Inclusion Complex Formation using Supercritical Carbon Dioxide

PCL-based nanofibers containing ibuprofen/cyclodextrins nanocontainers: A potential candidate for drug delivery application

“…CDs inclusion complex are divided into channel-type and cage type. By incorporation of IBU guest molecules in CDs cavity in the structure of channel-type, characteristic peaks are seen at 2y = 7.5, 11, 13, 14, 18, 20, 22, 25. In the cage type, each cavity is blocked off on both sides by adjacent CDs and characteristic peaks are seen at 2y = 5, 8, 12, 23, 30 [5][6][7][8]17,[19][20][21]. The XRD patterns of pure IBU, a-CD, b-CD, and the inclusion complexes are illustrated in Figures 3 and 4 and the characteristic peaks are shown in Table. 1.…”

“…Characteristic peaks of IBU are seen at 1740 cm À1 which is related to carbonyl stretching. Formation of the inclusion complex via hydrogen bonding caused to narrow the broad peak corresponding to hydroxyl band at 3370.72 cm À1 which is an indication of the formation of the inclusion complex [17,[19][20][21]. Due to the formation of inclusion complex between hydroxyl groups of the CDs cavity and carbonyl groups of IBU, stretching vibrations of the -OH groups in CD considerably disappeared.…”

“…Interior protons of CDs took part in the interaction due to the deep penetration of the IBU molecule into the b-CD cavity and the site of interaction could be the secondary alcoholic group at H-3 [5][6][7][8]17,[19][20][21]. Therefore, this shift provides the indication for the formation of the inclusion complex between CDs and IBU, which indicated FTIR results of inclusion complexes.…”

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

“…Drug References geraniol, mustard oil [12] acetaminophen [13] piroxicam [14,15] miconazole [15,16,17,18,19,20] Eflucimibe [21,22] ibuprofen [23,24,25,26,27,28,29] naproxen [28,30,31,32] flurbiprofen [28] citral, thymol, carvacrol [33] imazalil [34] salicylic acid [35] azobenzene [36] budesonide [37,38,39] indomethacin [40] polyaniline [41] cholesterol [42] arylphosphines [43] itraconazole [44,45,46] 2 sodium salts [47] hydroxyflavone [48] benzocaine [50, 49,] bupivacaine, and mepivacaine [50] simvastatin [51] several triphenyl phosphine derivatives [52] all-trans-lycopene [53] 15 carbohydrates [54] human serum immunoglobulin G …”

The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity

“…It follows that, the formation of a monomeric dispersion of the drug, as a consequence of the interaction with βCD could result in the inclusion of the drug monomer into the hydrophobic cavity of the CD. In the spectra of IB-βCD PM (Fig 5b 1 ) the carbonyl stretching band appeared at the same wavenumber (1721.3 cm -1 ) of the pure drug IB (Fig.5a 2 ) [14,[25][26][27][28][29][30][31]. Other spectra (not shown) presented shifts in this peak which corresponds to the carbonyl group (1737.4 cm -1 for IB-βCD AS, 1742.9 cm -1 for IB-βCD SD, 1743.2 cm -1 for IB-βCD FD, 1736.0 cm -1 for IB-βCD AS* higher frequency and 1708.5 cm -1 for IB-βCD K30 and 1709.1 cm -1 for IB-βCD K70 lower frequency).…”